Reproductive factors, hormonal interventions, and gastric cancer risk in the Stomach cancer Pooling (StoP) Project
© 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply..
BACKGROUND: Gastric cancer incidence is higher in men, and a protective hormone-related effect in women is postulated. We aimed to investigate and quantify the relationship in the Stomach cancer Pooling (StoP) Project consortium.
METHODS: A total of 2,084 cases and 7,102 controls from 11 studies in seven countries were included. Summary odds ratios (ORs) and 95% confidence intervals (CIs) assessing associations of key reproductive factors and menopausal hormone therapy (MHT) with gastric cancer were estimated by pooling study-specific ORs using random-effects meta-analysis.
RESULTS: A duration of fertility of ≥ 40 years (vs. < 20), was associated with a 25% lower risk of gastric cancer (OR = 0.75; 95% CI: 0.58-0.96). Compared with never use, ever, 5-9 years and ≥ 10 years use of MHT in postmenopausal women, showed ORs of 0.73 (95% CI: 0.58-0.92), 0.53 (95% CI: 0.34-0.84) and 0.71 (95% CI: 0.50-1.00), respectively. The associations were generally similar for anatomical and histologic subtypes.
CONCLUSION: Our results support the hypothesis that reproductive factors and MHT use may lower the risk of gastric cancer in women, regardless of anatomical or histologic subtypes. Given the variation in hormones over the lifespan, studies should address their effects in premenopausal and postmenopausal women. Furthermore, mechanistic studies may inform potential biological processes.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:35 |
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| Enthalten in: |
Cancer causes & control : CCC - 35(2024), 4 vom: 21. März, Seite 727-737 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Song, Minkyo [VerfasserIn] |
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| Links: |
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| Themen: |
Estrogens |
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| Anmerkungen: |
Date Completed 25.03.2024 Date Revised 25.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s10552-023-01829-1 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM366144065 |
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| 100 | 1 | |a Song, Minkyo |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Reproductive factors, hormonal interventions, and gastric cancer risk in the Stomach cancer Pooling (StoP) Project |
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| 500 | |a Date Revised 25.03.2024 | ||
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply. | ||
| 520 | |a BACKGROUND: Gastric cancer incidence is higher in men, and a protective hormone-related effect in women is postulated. We aimed to investigate and quantify the relationship in the Stomach cancer Pooling (StoP) Project consortium | ||
| 520 | |a METHODS: A total of 2,084 cases and 7,102 controls from 11 studies in seven countries were included. Summary odds ratios (ORs) and 95% confidence intervals (CIs) assessing associations of key reproductive factors and menopausal hormone therapy (MHT) with gastric cancer were estimated by pooling study-specific ORs using random-effects meta-analysis | ||
| 520 | |a RESULTS: A duration of fertility of ≥ 40 years (vs. < 20), was associated with a 25% lower risk of gastric cancer (OR = 0.75; 95% CI: 0.58-0.96). Compared with never use, ever, 5-9 years and ≥ 10 years use of MHT in postmenopausal women, showed ORs of 0.73 (95% CI: 0.58-0.92), 0.53 (95% CI: 0.34-0.84) and 0.71 (95% CI: 0.50-1.00), respectively. The associations were generally similar for anatomical and histologic subtypes | ||
| 520 | |a CONCLUSION: Our results support the hypothesis that reproductive factors and MHT use may lower the risk of gastric cancer in women, regardless of anatomical or histologic subtypes. Given the variation in hormones over the lifespan, studies should address their effects in premenopausal and postmenopausal women. Furthermore, mechanistic studies may inform potential biological processes | ||
| 650 | 4 | |a Meta-Analysis | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Estrogens | |
| 650 | 4 | |a MHT | |
| 650 | 4 | |a Postmenopause | |
| 650 | 4 | |a Premenopause | |
| 700 | 1 | |a Jayasekara, Harindra |e verfasserin |4 aut | |
| 700 | 1 | |a Pelucchi, Claudio |e verfasserin |4 aut | |
| 700 | 1 | |a Rabkin, Charles S |e verfasserin |4 aut | |
| 700 | 1 | |a Johnson, Kenneth C |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Jinfu |e verfasserin |4 aut | |
| 700 | 1 | |a Palli, Domenico |e verfasserin |4 aut | |
| 700 | 1 | |a Ferraroni, Monica |e verfasserin |4 aut | |
| 700 | 1 | |a Liao, Linda M |e verfasserin |4 aut | |
| 700 | 1 | |a Bonzi, Rossella |e verfasserin |4 aut | |
| 700 | 1 | |a Zaridze, David |e verfasserin |4 aut | |
| 700 | 1 | |a Maximovitch, Dmitry |e verfasserin |4 aut | |
| 700 | 1 | |a Aragonés, Nuria |e verfasserin |4 aut | |
| 700 | 1 | |a Martin, Vicente |e verfasserin |4 aut | |
| 700 | 1 | |a Castaño-Vinyals, Gemma |e verfasserin |4 aut | |
| 700 | 1 | |a Guevara, Marcela |e verfasserin |4 aut | |
| 700 | 1 | |a Tsugane, Shoichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Hamada, Gerson Shigueaki |e verfasserin |4 aut | |
| 700 | 1 | |a Hidaka, Akihisa |e verfasserin |4 aut | |
| 700 | 1 | |a Negri, Eva |e verfasserin |4 aut | |
| 700 | 1 | |a Ward, Mary H |e verfasserin |4 aut | |
| 700 | 1 | |a Sinha, Rashmi |e verfasserin |4 aut | |
| 700 | 1 | |a Lagiou, Areti |e verfasserin |4 aut | |
| 700 | 1 | |a Lagiou, Pagona |e verfasserin |4 aut | |
| 700 | 1 | |a Boffetta, Paolo |e verfasserin |4 aut | |
| 700 | 1 | |a Curado, Maria Paula |e verfasserin |4 aut | |
| 700 | 1 | |a Lunet, Nuno |e verfasserin |4 aut | |
| 700 | 1 | |a Vioque, Jesus |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Zuo-Feng |e verfasserin |4 aut | |
| 700 | 1 | |a La Vecchia, Carlo |e verfasserin |4 aut | |
| 700 | 1 | |a Camargo, M Constanza |e verfasserin |4 aut | |
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