Multiparametric Cardiovascular MRI Assessment of Post-COVID Syndrome in Children in Comparison to Matched Healthy Individuals
Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc..
BACKGROUND: Post-COVID syndrome (PCS) can adversely affect the quality of life of patients and their families. In particular, the degree of cardiac impairment in children with PCS is unknown.
OBJECTIVE: The aim of this study was to identify potential cardiac inflammatory sequelae in children with PCS compared with healthy controls.
METHODS: This single-center, prospective, intraindividual, observational study assesses cardiac function, global and segment-based strains, and tissue characterization in 29 age- and sex-matched children with PCS and healthy children using a 3 T magnetic resonance imaging (MRI).
RESULTS: Cardiac MRI was carried out over 36.4 ± 24.9 weeks post-COVID infection. The study cohort has an average age of 14.0 ± 2.8 years, for which the majority of individuals experience from fatigue, concentration disorders, dyspnea, dizziness, and muscle ache. Children with PSC in contrast to the control group exhibited elevated heart rate (83.7 ± 18.1 beats per minute vs 75.2 ± 11.2 beats per minute, P = 0.019), increased indexed right ventricular end-diastolic volume (95.2 ± 19.2 mlm-2 vs 82.0 ± 21.5 mlm-2, P = 0.018) and end-systolic volume (40.3 ± 7.9 mlm-2 vs 34.8 ± 6.2 mlm-2, P = 0.005), and elevated basal and midventricular T1 and T2 relaxation times (P < 0.001 to P = 0.013). Based on the updated Lake Louise Criteria, myocardial inflammation is present in 20 (69%) children with PCS. No statistically significant difference was observed for global strains.
CONCLUSIONS: Cardiac MRI revealed altered right ventricular volumetrics and elevated T1 and T2 mapping values in children with PCS, suggestive for a diffuse myocardial inflammation, which may be useful for the diagnostic workup of PCS in children.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2023 |
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| Enthalten in: |
Investigative radiology - (2023) vom: 18. Dez. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Eckstein, Jan [VerfasserIn] |
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Date Revised 20.12.2023 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1097/RLI.0000000000001048 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
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| 100 | 1 | |a Eckstein, Jan |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Multiparametric Cardiovascular MRI Assessment of Post-COVID Syndrome in Children in Comparison to Matched Healthy Individuals |
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| 520 | |a Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. | ||
| 520 | |a BACKGROUND: Post-COVID syndrome (PCS) can adversely affect the quality of life of patients and their families. In particular, the degree of cardiac impairment in children with PCS is unknown | ||
| 520 | |a OBJECTIVE: The aim of this study was to identify potential cardiac inflammatory sequelae in children with PCS compared with healthy controls | ||
| 520 | |a METHODS: This single-center, prospective, intraindividual, observational study assesses cardiac function, global and segment-based strains, and tissue characterization in 29 age- and sex-matched children with PCS and healthy children using a 3 T magnetic resonance imaging (MRI) | ||
| 520 | |a RESULTS: Cardiac MRI was carried out over 36.4 ± 24.9 weeks post-COVID infection. The study cohort has an average age of 14.0 ± 2.8 years, for which the majority of individuals experience from fatigue, concentration disorders, dyspnea, dizziness, and muscle ache. Children with PSC in contrast to the control group exhibited elevated heart rate (83.7 ± 18.1 beats per minute vs 75.2 ± 11.2 beats per minute, P = 0.019), increased indexed right ventricular end-diastolic volume (95.2 ± 19.2 mlm-2 vs 82.0 ± 21.5 mlm-2, P = 0.018) and end-systolic volume (40.3 ± 7.9 mlm-2 vs 34.8 ± 6.2 mlm-2, P = 0.005), and elevated basal and midventricular T1 and T2 relaxation times (P < 0.001 to P = 0.013). Based on the updated Lake Louise Criteria, myocardial inflammation is present in 20 (69%) children with PCS. No statistically significant difference was observed for global strains | ||
| 520 | |a CONCLUSIONS: Cardiac MRI revealed altered right ventricular volumetrics and elevated T1 and T2 mapping values in children with PCS, suggestive for a diffuse myocardial inflammation, which may be useful for the diagnostic workup of PCS in children | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Skeries, Valentina |e verfasserin |4 aut | |
| 700 | 1 | |a Pöhler, Gesa |e verfasserin |4 aut | |
| 700 | 1 | |a Babazade, Nigar |e verfasserin |4 aut | |
| 700 | 1 | |a Kaireit, Till |e verfasserin |4 aut | |
| 700 | 1 | |a Gutberlet, Marcel |e verfasserin |4 aut | |
| 700 | 1 | |a Kornemann, Norman |e verfasserin |4 aut | |
| 700 | 1 | |a Hellms, Susanne |e verfasserin |4 aut | |
| 700 | 1 | |a Pfeil, Alexander |e verfasserin |4 aut | |
| 700 | 1 | |a Bucher, Andreas Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Hansmann, Georg |e verfasserin |4 aut | |
| 700 | 1 | |a Beerbaum, Philipp |e verfasserin |4 aut | |
| 700 | 1 | |a Hansen, Gesine |e verfasserin |4 aut | |
| 700 | 1 | |a Wacker, Frank |e verfasserin |4 aut | |
| 700 | 1 | |a Vogel-Claussen, Jens |e verfasserin |4 aut | |
| 700 | 1 | |a Wetzke, Martin |e verfasserin |4 aut | |
| 700 | 1 | |a Renz, Diane Miriam |e verfasserin |4 aut | |
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