Comparison of distribution of eight components from Liangxue Tuizi Mixture between normal and Henoch-Schonlein purpura rats
This study used UPLC-TQ-MS technology to replicate a Henoch-Schonlein purpura(HSP) model in rats by administering warm drugs by gavage and injecting ovalbumin with Freund's complete adjuvant emulsion. The distribution differences and characteristics of eight major components(ferulic acid, caffeic acid, neochlorogenic acid, cryptochlorogenic acid, benzoyl oxypaeoniflorin, tracheloside, loganin, and paeoniflorin) in rat liver, lung, heart, spleen, and kidney tissues were determined after oral administration of the Liangxue Tuizi Mixture at a dose of 42 g·kg~(-1) in both normal physiological and HSP states at 0.5, 1, 2, 6, and 12 hours. The results showed that the distribution patterns of the eight components of Liangxue Tuizi Mixture in the tissues of normal and HSP model rats were different. The main component, paeoniflorin, in Moutan Cortex and Paeoniae Radix Alba had higher content in all tissues. The eight components were predominantly distributed in the liver, lung, and kidney tissues, followed by spleen and heart tissues.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:48 |
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| Enthalten in: |
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica - 48(2023), 21 vom: 15. Nov., Seite 5915-5931 |
| Sprache: |
Chinesisch |
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| Beteiligte Personen: |
Si, Li-Ling [VerfasserIn] |
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| Links: |
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| Themen: |
21AIQ4EV64 |
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| Anmerkungen: |
Date Completed 21.12.2023 Date Revised 21.12.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.19540/j.cnki.cjcmm.20230618.202 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM366048554 |
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| 100 | 1 | |a Si, Li-Ling |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Comparison of distribution of eight components from Liangxue Tuizi Mixture between normal and Henoch-Schonlein purpura rats |
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| 500 | |a Date Completed 21.12.2023 | ||
| 500 | |a Date Revised 21.12.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a This study used UPLC-TQ-MS technology to replicate a Henoch-Schonlein purpura(HSP) model in rats by administering warm drugs by gavage and injecting ovalbumin with Freund's complete adjuvant emulsion. The distribution differences and characteristics of eight major components(ferulic acid, caffeic acid, neochlorogenic acid, cryptochlorogenic acid, benzoyl oxypaeoniflorin, tracheloside, loganin, and paeoniflorin) in rat liver, lung, heart, spleen, and kidney tissues were determined after oral administration of the Liangxue Tuizi Mixture at a dose of 42 g·kg~(-1) in both normal physiological and HSP states at 0.5, 1, 2, 6, and 12 hours. The results showed that the distribution patterns of the eight components of Liangxue Tuizi Mixture in the tissues of normal and HSP model rats were different. The main component, paeoniflorin, in Moutan Cortex and Paeoniae Radix Alba had higher content in all tissues. The eight components were predominantly distributed in the liver, lung, and kidney tissues, followed by spleen and heart tissues | ||
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Henoch-Schonlein purpura | |
| 650 | 4 | |a Liangxue Tuizi Mixture | |
| 650 | 4 | |a UPLC-TQ-MS | |
| 650 | 4 | |a tissue distribution | |
| 650 | 7 | |a peoniflorin |2 NLM | |
| 650 | 7 | |a 21AIQ4EV64 |2 NLM | |
| 650 | 7 | |a Monoterpenes |2 NLM | |
| 700 | 1 | |a Niu, Lu |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Xiao-Yan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Hui |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Ming-Liang |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Shuang |e verfasserin |4 aut | |
| 700 | 1 | |a Ren, Xian-Qing |e verfasserin |4 aut | |
| 700 | 1 | |a Tang, Jin-Fa |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Wei-Xia |e verfasserin |4 aut | |
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