Platelet-to-lymphocyte ratio as a biomarker for predicting coronary artery lesions in Chinese children with Kawasaki disease : a Meta analysis
OBJECTIVES: To systematically evaluate the value of the platelet-to-lymphocyte ratio (PLR) in predicting coronary artery lesions (CAL) in Chinese children with Kawasaki Disease (KD).
METHODS: A comprehensive search was conducted in databases including PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Wanfang Data, China Biomedical Literature Database, and China Science and Technology Journal Database from inception to December 2022. The quality of the included literature was assessed using the Newcastle-Ottawa Scale, and a Meta analysis was performed using Stata 15.1.
RESULTS: A total of ten published reports, involving 3 664 Chinese children with KD, were included in this Meta analysis, of whom 1 328 developed CAL. The Meta analysis revealed a sensitivity of 0.78 (95%CI: 0.71-0.83), specificity of 0.71 (95%CI: 0.61-0.80), overall diagnostic odds ratio of 8.69 (95%CI: 5.02-15.06), and an area under the curve of the summary receiver operating characteristic of 0.82 (95%CI: 0.78-0.85) for PLR in predicting CAL in the children with KD. The sensitivity, specificity, and area under the curve of summary receiver operating characteristic were lower for PLR alone compared to PLR in combination with other indicators. Sensitivity analysis demonstrated the stability of the Meta analysis results with no significant changes upon excluding individual studies. However, a significant publication bias was observed (P<0.001).
CONCLUSIONS: PLR demonstrates certain predictive value for CAL in Chinese children with KD.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:25 |
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| Enthalten in: |
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics - 25(2023), 12 vom: 15. Dez., Seite 1219-1226 |
| Sprache: |
Chinesisch |
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| Weiterer Titel: |
血小板与淋巴细胞比值对中国川崎病患儿冠状动脉病变预测价值的Meta分析 |
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| Beteiligte Personen: |
Li, Yan-Yu [VerfasserIn] |
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| Links: |
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| Themen: |
Biomarkers |
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| Anmerkungen: |
Date Completed 20.12.2023 Date Revised 22.12.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.7499/j.issn.1008-8830.2306097 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM366028421 |
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| 245 | 1 | 0 | |a Platelet-to-lymphocyte ratio as a biomarker for predicting coronary artery lesions in Chinese children with Kawasaki disease |b a Meta analysis |
| 246 | 3 | 3 | |a 血小板与淋巴细胞比值对中国川崎病患儿冠状动脉病变预测价值的Meta分析 |
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| 500 | |a Date Revised 22.12.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVES: To systematically evaluate the value of the platelet-to-lymphocyte ratio (PLR) in predicting coronary artery lesions (CAL) in Chinese children with Kawasaki Disease (KD) | ||
| 520 | |a METHODS: A comprehensive search was conducted in databases including PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Wanfang Data, China Biomedical Literature Database, and China Science and Technology Journal Database from inception to December 2022. The quality of the included literature was assessed using the Newcastle-Ottawa Scale, and a Meta analysis was performed using Stata 15.1 | ||
| 520 | |a RESULTS: A total of ten published reports, involving 3 664 Chinese children with KD, were included in this Meta analysis, of whom 1 328 developed CAL. The Meta analysis revealed a sensitivity of 0.78 (95%CI: 0.71-0.83), specificity of 0.71 (95%CI: 0.61-0.80), overall diagnostic odds ratio of 8.69 (95%CI: 5.02-15.06), and an area under the curve of the summary receiver operating characteristic of 0.82 (95%CI: 0.78-0.85) for PLR in predicting CAL in the children with KD. The sensitivity, specificity, and area under the curve of summary receiver operating characteristic were lower for PLR alone compared to PLR in combination with other indicators. Sensitivity analysis demonstrated the stability of the Meta analysis results with no significant changes upon excluding individual studies. However, a significant publication bias was observed (P<0.001) | ||
| 520 | |a CONCLUSIONS: PLR demonstrates certain predictive value for CAL in Chinese children with KD | ||
| 650 | 4 | |a Meta-Analysis | |
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Child | |
| 650 | 4 | |a Coronary artery lesion | |
| 650 | 4 | |a Kawasaki disease | |
| 650 | 4 | |a Meta analysis | |
| 650 | 4 | |a Platelet-to-lymphocyte ratio | |
| 650 | 7 | |a Biomarkers |2 NLM | |
| 700 | 1 | |a Yuan, Chen-Chen |e verfasserin |4 aut | |
| 700 | 1 | |a Cai, Ai-Yuan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Bo-Ju |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Teng |e verfasserin |4 aut | |
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