Research advances in genetic polymorphisms in Kawasaki disease
Kawasaki disease (KD) is a systemic inflammatory vascular disorder that predominantly affects children and is the leading cause of acquired heart disease in children. Although the etiology of this disease remains unclear, genome-wide association and genome-wide linkage studies have shown that some susceptible genes and chromosomal regions are associated with the development and progression of KD. With the advancement of high-throughput DNA sequencing techniques, more and more genomic information related to KD is being discovered. Understanding the genes involved in the pathogenesis of KD may provide novel insights into the diagnosis and treatment of KD. By analyzing related articles and summarizing related research advances, this article mainly discusses the T cell activation-enhancing genes that have been confirmed to be closely associated with the development and progression of KD and reveals their association with the pathogenesis of KD and coronary artery lesions.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:25 |
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| Enthalten in: |
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics - 25(2023), 12 vom: 15. Dez., Seite 1234-1238 |
| Sprache: |
Chinesisch |
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| Weiterer Titel: |
川崎病基因多态性的研究进展 |
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| Beteiligte Personen: |
Dong, Ming-Xing [VerfasserIn] |
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| Links: |
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| Themen: |
Coronary artery lesion |
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| Anmerkungen: |
Date Completed 20.12.2023 Date Revised 22.12.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.7499/j.issn.1008-8830.2308073 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM366028375 |
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| 246 | 3 | 3 | |a 川崎病基因多态性的研究进展 |
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| 520 | |a Kawasaki disease (KD) is a systemic inflammatory vascular disorder that predominantly affects children and is the leading cause of acquired heart disease in children. Although the etiology of this disease remains unclear, genome-wide association and genome-wide linkage studies have shown that some susceptible genes and chromosomal regions are associated with the development and progression of KD. With the advancement of high-throughput DNA sequencing techniques, more and more genomic information related to KD is being discovered. Understanding the genes involved in the pathogenesis of KD may provide novel insights into the diagnosis and treatment of KD. By analyzing related articles and summarizing related research advances, this article mainly discusses the T cell activation-enhancing genes that have been confirmed to be closely associated with the development and progression of KD and reveals their association with the pathogenesis of KD and coronary artery lesions | ||
| 650 | 4 | |a English Abstract | |
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| 650 | 4 | |a Coronary artery lesion | |
| 650 | 4 | |a Genetic polymorphism | |
| 650 | 4 | |a Kawasaki disease | |
| 650 | 4 | |a Susceptibility | |
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| 700 | 1 | |a Jiao, Fu-Yong |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Wei-Hua |e verfasserin |4 aut | |
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