Neurogenesis impairment with glial activation in the hippocampus-connected regions of intracerebroventricular streptozotocin-injected mice
Copyright © 2023 Elsevier B.V. All rights reserved..
Adult neurogenesis in the hippocampus and subventricular zone (SVZ) is impaired by intracerebroventricular administration of streptozotocin (icv-STZ) to rodents. Although neural cells in the several brain regions which connect with the hippocampus or SVZ is thought to be involved in the adult neurogenesis, few studies have investigated morphological alterations of glial cells in these areas. The present study revealed that icv-STZ induces reduction of neural progenitor cells and a dramatic increase in reactive astrocytes and microglia especially in the hippocampus and various hippocampus-connected brain areas. In contrast, there was no significant neuronal damage excluding demyelination of the stria medullaris. The results indicate the hippocampal neurogenesis impairment of this model might be occurred by activated glial cells in the hippocampus, or hippocampus-connected regions.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:820 |
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| Enthalten in: |
Neuroscience letters - 820(2024) vom: 18. Jan., Seite 137598 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Masai, Kaori [VerfasserIn] |
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| Links: |
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| Themen: |
5W494URQ81 |
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| Anmerkungen: |
Date Completed 08.01.2024 Date Revised 08.01.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.neulet.2023.137598 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM366008455 |
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| 245 | 1 | 0 | |a Neurogenesis impairment with glial activation in the hippocampus-connected regions of intracerebroventricular streptozotocin-injected mice |
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| 520 | |a Copyright © 2023 Elsevier B.V. All rights reserved. | ||
| 520 | |a Adult neurogenesis in the hippocampus and subventricular zone (SVZ) is impaired by intracerebroventricular administration of streptozotocin (icv-STZ) to rodents. Although neural cells in the several brain regions which connect with the hippocampus or SVZ is thought to be involved in the adult neurogenesis, few studies have investigated morphological alterations of glial cells in these areas. The present study revealed that icv-STZ induces reduction of neural progenitor cells and a dramatic increase in reactive astrocytes and microglia especially in the hippocampus and various hippocampus-connected brain areas. In contrast, there was no significant neuronal damage excluding demyelination of the stria medullaris. The results indicate the hippocampal neurogenesis impairment of this model might be occurred by activated glial cells in the hippocampus, or hippocampus-connected regions | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Adult neurogenesis | |
| 650 | 4 | |a Astrocyte | |
| 650 | 4 | |a Microglia | |
| 650 | 4 | |a Streptozotocin | |
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| 700 | 1 | |a Nakayama, Yuta |e verfasserin |4 aut | |
| 700 | 1 | |a Shin, Kotaro |e verfasserin |4 aut | |
| 700 | 1 | |a Sugahara, Chiaki |e verfasserin |4 aut | |
| 700 | 1 | |a Miyazaki, Ikuko |e verfasserin |4 aut | |
| 700 | 1 | |a Yasuhara, Takao |e verfasserin |4 aut | |
| 700 | 1 | |a Date, Isao |e verfasserin |4 aut | |
| 700 | 1 | |a Asanuma, Masato |e verfasserin |4 aut | |
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