Exosomal miRNAs in autoimmune skin diseases
Copyright © 2023 Zhang, Wei, Wang, Nie, Shi, Deng and Li..
Exosomes, bilaterally phospholipid-coated small vesicles, are produced and released by nearly all cells, which comprise diverse biological macromolecules, including proteins, DNA, RNA, and others, that participate in the regulation of their biological functions. An increasing number of studies have revealed that the contents of exosomes, particularly microRNA(miRNA), play a significant role in the pathogenesis of various diseases, including autoimmune skin diseases. MiRNA is a class of single-stranded non-coding RNA molecules that possess approximately 22 nucleotides in length with the capability of binding to the untranslated as well as coding regions of target mRNA to regulate gene expression precisely at the post-transcriptional level. Various exosomal miRNAs have been found to be significantly expressed in some autoimmune skin diseases and involved in the pathogenesis of conditions via regulating the secretion of crucial pathogenic cytokines and the direction of immune cell differentiation. Thus, exosomal miRNAs might be promising biomarkers for monitoring disease progression, relapse and reflection to treatment based on their functions and changes. This review summarized the current studies on exosomal miRNAs in several common autoimmune skin diseases, aiming to dissect the underlying mechanism from a new perspective, seek novel biomarkers for disease monitoring and lay the foundation for developing innovative target therapy in the future.
| Errataetall: |
CommentOn: Clin Cosmet Investig Dermatol. 2022 Jul 18;15:1377-1386. - PMID 35880009 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Frontiers in immunology - 14(2023) vom: 05., Seite 1307455 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhang, Ri [VerfasserIn] |
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| Links: |
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| Themen: |
Autoimmune skin disease |
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| Anmerkungen: |
Date Completed 19.12.2023 Date Revised 03.04.2024 published: Electronic-eCollection CommentOn: Clin Cosmet Investig Dermatol. 2022 Jul 18;15:1377-1386. - PMID 35880009 Citation Status MEDLINE |
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| doi: |
10.3389/fimmu.2023.1307455 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM365971049 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 Zhang, Wei, Wang, Nie, Shi, Deng and Li. | ||
| 520 | |a Exosomes, bilaterally phospholipid-coated small vesicles, are produced and released by nearly all cells, which comprise diverse biological macromolecules, including proteins, DNA, RNA, and others, that participate in the regulation of their biological functions. An increasing number of studies have revealed that the contents of exosomes, particularly microRNA(miRNA), play a significant role in the pathogenesis of various diseases, including autoimmune skin diseases. MiRNA is a class of single-stranded non-coding RNA molecules that possess approximately 22 nucleotides in length with the capability of binding to the untranslated as well as coding regions of target mRNA to regulate gene expression precisely at the post-transcriptional level. Various exosomal miRNAs have been found to be significantly expressed in some autoimmune skin diseases and involved in the pathogenesis of conditions via regulating the secretion of crucial pathogenic cytokines and the direction of immune cell differentiation. Thus, exosomal miRNAs might be promising biomarkers for monitoring disease progression, relapse and reflection to treatment based on their functions and changes. This review summarized the current studies on exosomal miRNAs in several common autoimmune skin diseases, aiming to dissect the underlying mechanism from a new perspective, seek novel biomarkers for disease monitoring and lay the foundation for developing innovative target therapy in the future | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Shi, Zeqi |e verfasserin |4 aut | |
| 700 | 1 | |a Deng, Yunhua |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Dong |e verfasserin |4 aut | |
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