Prognostic Impact of the Modified 5-Item Frailty Index After Radical Nephroureterectomy in Patients With Upper Tract Urothelial Carcinoma : A Multicenter Retrospective Study
Copyright © 2023 Elsevier Inc. All rights reserved..
INTRODUCTION: The modified 5-item frailty index can be used to evaluate frailty using 5 routinely encountered clinical variables. This study aimed to assess the impact of the modified 5-item frailty index in patients who underwent radical nephroureterectomy for upper tract urothelial carcinoma.
PATIENTS AND METHODS: In this multicenter retrospective study, we calculated the modified 5-item frailty index scores of patients who underwent radical nephroureterectomy for upper tract urothelial carcinoma between 2010 and 2022. Patients were categorized into the high (≥2) and low (≤1) modified 5-item frailty index score groups. To assess the prognostic influence of the preoperative modified 5-item frailty index, we conducted Cox proportional regression analyses concerning progression-free, overall, and cancer-specific survival.
RESULTS: Of 434 patients, 82, and 352 were classified into the high and low modified 5-item frailty index score groups, respectively. The high modified 5-item frailty index score group had significantly higher rates of severe surgical complications (P = .038) and ≥30 days of hospitalization (P = .049) and significantly worse progression-free (P = .012) and overall survival (P = .002) than the low modified 5-item frailty index score group. The multivariable Cox proportional hazard analysis revealed that a high modified 5-item frailty index score was independently associated with poor progression-free (P = .044), overall (P = .017), and cancer-specific survival (P = .005).
CONCLUSION: The modified 5-item frailty index emerged as a significant predictive indicator of severe surgical complications and postoperative survival outcomes in patients with upper tract urothelial carcinoma treated with radical nephroureterectomy.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
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| Enthalten in: |
Clinical genitourinary cancer - 22(2024), 2 vom: 25. Apr., Seite 322-329.e3 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kohada, Yuki [VerfasserIn] |
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| Links: |
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| Themen: |
Biomarkers |
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| Anmerkungen: |
Date Completed 11.03.2024 Date Revised 09.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.clgc.2023.11.015 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM365947296 |
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| 100 | 1 | |a Kohada, Yuki |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Prognostic Impact of the Modified 5-Item Frailty Index After Radical Nephroureterectomy in Patients With Upper Tract Urothelial Carcinoma |b A Multicenter Retrospective Study |
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| 520 | |a Copyright © 2023 Elsevier Inc. All rights reserved. | ||
| 520 | |a INTRODUCTION: The modified 5-item frailty index can be used to evaluate frailty using 5 routinely encountered clinical variables. This study aimed to assess the impact of the modified 5-item frailty index in patients who underwent radical nephroureterectomy for upper tract urothelial carcinoma | ||
| 520 | |a PATIENTS AND METHODS: In this multicenter retrospective study, we calculated the modified 5-item frailty index scores of patients who underwent radical nephroureterectomy for upper tract urothelial carcinoma between 2010 and 2022. Patients were categorized into the high (≥2) and low (≤1) modified 5-item frailty index score groups. To assess the prognostic influence of the preoperative modified 5-item frailty index, we conducted Cox proportional regression analyses concerning progression-free, overall, and cancer-specific survival | ||
| 520 | |a RESULTS: Of 434 patients, 82, and 352 were classified into the high and low modified 5-item frailty index score groups, respectively. The high modified 5-item frailty index score group had significantly higher rates of severe surgical complications (P = .038) and ≥30 days of hospitalization (P = .049) and significantly worse progression-free (P = .012) and overall survival (P = .002) than the low modified 5-item frailty index score group. The multivariable Cox proportional hazard analysis revealed that a high modified 5-item frailty index score was independently associated with poor progression-free (P = .044), overall (P = .017), and cancer-specific survival (P = .005) | ||
| 520 | |a CONCLUSION: The modified 5-item frailty index emerged as a significant predictive indicator of severe surgical complications and postoperative survival outcomes in patients with upper tract urothelial carcinoma treated with radical nephroureterectomy | ||
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Biomarkers | |
| 650 | 4 | |a Geriatric assessment | |
| 650 | 4 | |a Prognosis | |
| 650 | 4 | |a Urogenital surgical procedures | |
| 650 | 4 | |a Urologic neoplasms | |
| 700 | 1 | |a Goto, Keisuke |e verfasserin |4 aut | |
| 700 | 1 | |a Tasaka, Ryo |e verfasserin |4 aut | |
| 700 | 1 | |a Nishida, Kensuke |e verfasserin |4 aut | |
| 700 | 1 | |a Hashimoto, Kunihiro |e verfasserin |4 aut | |
| 700 | 1 | |a Iwamoto, Hideo |e verfasserin |4 aut | |
| 700 | 1 | |a Hatayama, Tomoya |e verfasserin |4 aut | |
| 700 | 1 | |a Furutani, Tomoki |e verfasserin |4 aut | |
| 700 | 1 | |a Miyamoto, Shunsuke |e verfasserin |4 aut | |
| 700 | 1 | |a Kobatake, Kohei |e verfasserin |4 aut | |
| 700 | 1 | |a Kitano, Hiroyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Ikeda, Kenichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Goriki, Akihiro |e verfasserin |4 aut | |
| 700 | 1 | |a Hieda, Keisuke |e verfasserin |4 aut | |
| 700 | 1 | |a Hayashi, Tetsutaro |e verfasserin |4 aut | |
| 700 | 1 | |a Hinata, Nobuyuki |e verfasserin |4 aut | |
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