Effect of aerobic exercise training on pulse wave velocity in adults with and without long-term conditions : a systematic review and meta-analysis
© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ..
RATIONALE: There is conflicting evidence whether aerobic exercise training (AET) reduces pulse wave velocity (PWV) in adults with and without long-term conditions (LTCs).
OBJECTIVE: To explore whether PWV improves with AET in adults with and without LTC, to quantify the magnitude of any effect and understand the influence of the exercise prescription.
DATA SOURCES: CENTRAL, MEDLINE and EMBASE were among the databases searched.
ELIGIBILITY CRITERIA: We included studies with a PWV measurement before and after supervised AET of at least 3 weeks duration. Exclusion criteria included resistance exercise and alternative measures of arterial stiffness.
DESIGN: Controlled trials were included in a random effects meta-analysis to explore the effect of AET on PWV. Uncontrolled studies were included in a secondary meta-analysis and meta-regression exploring the effect of patient and programme factors on change in PWV. The relevant risk of bias tool was used for each study design.
RESULTS: 79 studies (n=3729) were included: 35 controlled studies (21 randomised control trials (RCT) (n=1240) and 12 non-RCT (n=463)) and 44 uncontrolled (n=2026). In the controlled meta- analysis, PWV was significantly reduced following AET (mean (SD) 11 (7) weeks) in adults with and without LTC (mean difference -0.63; 95% CI -0.82 to -0.44; p<0.0001). PWV was similarly reduced between adults with and without LTC (p<0.001). Age, but not specific programme factors, was inversely associated with a reduction in PWV -0.010 (-0.020 to -0.010) m/s, p<0.001.
DISCUSSION: Short-term AET similarly reduces PWV in adults with and without LTC. Whether this effect is sustained and the clinical implications require further investigation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
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| Enthalten in: |
Open heart - 10(2023), 2 vom: 14. Dez. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Bakali, Majda [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 18.12.2023 Date Revised 21.12.2023 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1136/openhrt-2023-002384 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM365925535 |
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| 245 | 1 | 0 | |a Effect of aerobic exercise training on pulse wave velocity in adults with and without long-term conditions |b a systematic review and meta-analysis |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. | ||
| 520 | |a RATIONALE: There is conflicting evidence whether aerobic exercise training (AET) reduces pulse wave velocity (PWV) in adults with and without long-term conditions (LTCs) | ||
| 520 | |a OBJECTIVE: To explore whether PWV improves with AET in adults with and without LTC, to quantify the magnitude of any effect and understand the influence of the exercise prescription | ||
| 520 | |a DATA SOURCES: CENTRAL, MEDLINE and EMBASE were among the databases searched | ||
| 520 | |a ELIGIBILITY CRITERIA: We included studies with a PWV measurement before and after supervised AET of at least 3 weeks duration. Exclusion criteria included resistance exercise and alternative measures of arterial stiffness | ||
| 520 | |a DESIGN: Controlled trials were included in a random effects meta-analysis to explore the effect of AET on PWV. Uncontrolled studies were included in a secondary meta-analysis and meta-regression exploring the effect of patient and programme factors on change in PWV. The relevant risk of bias tool was used for each study design | ||
| 520 | |a RESULTS: 79 studies (n=3729) were included: 35 controlled studies (21 randomised control trials (RCT) (n=1240) and 12 non-RCT (n=463)) and 44 uncontrolled (n=2026). In the controlled meta- analysis, PWV was significantly reduced following AET (mean (SD) 11 (7) weeks) in adults with and without LTC (mean difference -0.63; 95% CI -0.82 to -0.44; p<0.0001). PWV was similarly reduced between adults with and without LTC (p<0.001). Age, but not specific programme factors, was inversely associated with a reduction in PWV -0.010 (-0.020 to -0.010) m/s, p<0.001 | ||
| 520 | |a DISCUSSION: Short-term AET similarly reduces PWV in adults with and without LTC. Whether this effect is sustained and the clinical implications require further investigation | ||
| 650 | 4 | |a Meta-Analysis | |
| 650 | 4 | |a Systematic Review | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Meta-Analysis | |
| 650 | 4 | |a Risk Factors | |
| 650 | 4 | |a Systematic Reviews as Topic | |
| 700 | 1 | |a Ward, Thomas Cj |e verfasserin |4 aut | |
| 700 | 1 | |a Daynes, Enya |e verfasserin |4 aut | |
| 700 | 1 | |a Jones, Amy V |e verfasserin |4 aut | |
| 700 | 1 | |a Hawthorne, Grace M |e verfasserin |4 aut | |
| 700 | 1 | |a Latimer, Lorna |e verfasserin |4 aut | |
| 700 | 1 | |a Divall, Pip |e verfasserin |4 aut | |
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| 700 | 1 | |a Steiner, Michael C |e verfasserin |4 aut | |
| 700 | 1 | |a Evans, Rachael Andrea |e verfasserin |4 aut | |
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