SKN-1/NRF2 upregulation by vitamin A is conserved from nematodes to mammals and is critical for lifespan extension in Caenorhabditis elegans
© 2023 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd..
Vitamin A (VA) is a micronutrient essential for the physiology of many organisms, but its role in longevity and age-related diseases remains unclear. In this work, we used Caenorhabditis elegans to study the impact of various bioactive compounds on lifespan. We demonstrate that VA extends lifespan and reduces lipofuscin and fat accumulation while increasing resistance to heat and oxidative stress. This resistance can be attributed to high levels of detoxifying enzymes called glutathione S-transferases, induced by the transcription factor skinhead-1 (SKN-1). Notably, VA upregulated the transcript levels of skn-1 or its mammalian ortholog NRF2 in both C. elegans, human cells, and liver tissues of mice. Moreover, the loss-of-function genetic models demonstrated a critical involvement of the SKN-1 pathway in longevity extension by VA. Our study thus provides novel insights into the molecular mechanism of anti-aging and anti-oxidative effects of VA, suggesting that this micronutrient could be used for the prevention and/or treatment of age-related disorders.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:23 |
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| Enthalten in: |
Aging cell - 23(2024), 3 vom: 01. März, Seite e14064 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sirakawin, Chaweewan [VerfasserIn] |
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| Links: |
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| Themen: |
11103-57-4 |
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| Anmerkungen: |
Date Completed 13.03.2024 Date Revised 14.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/acel.14064 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
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| 245 | 1 | 0 | |a SKN-1/NRF2 upregulation by vitamin A is conserved from nematodes to mammals and is critical for lifespan extension in Caenorhabditis elegans |
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| 520 | |a © 2023 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. | ||
| 520 | |a Vitamin A (VA) is a micronutrient essential for the physiology of many organisms, but its role in longevity and age-related diseases remains unclear. In this work, we used Caenorhabditis elegans to study the impact of various bioactive compounds on lifespan. We demonstrate that VA extends lifespan and reduces lipofuscin and fat accumulation while increasing resistance to heat and oxidative stress. This resistance can be attributed to high levels of detoxifying enzymes called glutathione S-transferases, induced by the transcription factor skinhead-1 (SKN-1). Notably, VA upregulated the transcript levels of skn-1 or its mammalian ortholog NRF2 in both C. elegans, human cells, and liver tissues of mice. Moreover, the loss-of-function genetic models demonstrated a critical involvement of the SKN-1 pathway in longevity extension by VA. Our study thus provides novel insights into the molecular mechanism of anti-aging and anti-oxidative effects of VA, suggesting that this micronutrient could be used for the prevention and/or treatment of age-related disorders | ||
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| 700 | 1 | |a Lin, Dongfa |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Ziyue |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Xiaoxin |e verfasserin |4 aut | |
| 700 | 1 | |a Kelleher, Rhianne |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Shangyuan |e verfasserin |4 aut | |
| 700 | 1 | |a Long, Weimiao |e verfasserin |4 aut | |
| 700 | 1 | |a Pires-daSilva, Andre |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Jingjing |e verfasserin |4 aut | |
| 700 | 1 | |a Vinnikov, Ilya A |e verfasserin |4 aut | |
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