Supramolecular Integration of Multifunctional Nanomaterial by Mannose-Decorated Azocalixarene with Ginsenoside Rb1 for Synergistic Therapy of Rheumatoid Arthritis
The complexity and progressive nature of diseases require the exploitation of multifunctional materials. However, introducing a function inevitably increases the complexity of materials, which complicates preparation and decreases reproducibility. Herein, we report a supramolecular integration of multifunctional nanomaterials based on mannose-modified azocalix[4]arene (ManAC4A) and ginsenoside Rb1 (Rb1), which showed advances of simplicity and reproducibility. ManAC4A possesses reactive oxygen species (ROS) scavenging capacity and hypoxia-responsiveness, together with macrophage-targeting and induction functionality. Collectively, the Rb1ManAC4A assembly simply prepared by two components is integrated with multifunction, including triple targeting (ELVIS targeting, macrophage-targeting, and hypoxia-targeted release) and triple therapy (ROS scavenging, macrophage polarization, and the anti-inflammatory effect of Rb1). The spontaneous assembly and recognition of ManAC4A, with its precise structure and molecular weight, facilitated the simple and straightforward preparation of Rb1@ManAC4A, leading to excellent batch consistency. Progress in simplicity and reproducibility, as directed by this research, will catalyze the clinical translation of multifunctional materials.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:17 |
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| Enthalten in: |
ACS nano - 17(2023), 24 vom: 26. Dez., Seite 25468-25482 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Li, Shihui [VerfasserIn] |
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| Links: |
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| Themen: |
7413S0WMH6 |
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| Anmerkungen: |
Date Completed 27.12.2023 Date Revised 27.12.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1021/acsnano.3c09140 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a The complexity and progressive nature of diseases require the exploitation of multifunctional materials. However, introducing a function inevitably increases the complexity of materials, which complicates preparation and decreases reproducibility. Herein, we report a supramolecular integration of multifunctional nanomaterials based on mannose-modified azocalix[4]arene (ManAC4A) and ginsenoside Rb1 (Rb1), which showed advances of simplicity and reproducibility. ManAC4A possesses reactive oxygen species (ROS) scavenging capacity and hypoxia-responsiveness, together with macrophage-targeting and induction functionality. Collectively, the Rb1ManAC4A assembly simply prepared by two components is integrated with multifunction, including triple targeting (ELVIS targeting, macrophage-targeting, and hypoxia-targeted release) and triple therapy (ROS scavenging, macrophage polarization, and the anti-inflammatory effect of Rb1). The spontaneous assembly and recognition of ManAC4A, with its precise structure and molecular weight, facilitated the simple and straightforward preparation of Rb1@ManAC4A, leading to excellent batch consistency. Progress in simplicity and reproducibility, as directed by this research, will catalyze the clinical translation of multifunctional materials | ||
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| 700 | 1 | |a Chen, Meng-Meng |e verfasserin |4 aut | |
| 700 | 1 | |a Su, Shan-Shan |e verfasserin |4 aut | |
| 700 | 1 | |a Yao, Shun-Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Ze-Han |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Xin-Yue |e verfasserin |4 aut | |
| 700 | 1 | |a Geng, Wen-Chao |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Ke-Rang |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Dong-Sheng |e verfasserin |4 aut | |
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