Association of radiotherapy for prostate cancer and second primary colorectal cancer : a US population-based analysis
© 2023. Springer Nature Switzerland AG..
BACKGROUND: Radiotherapy (RT) is a common treatment for prostate cancer, yet the risk of second primary colorectal cancer (SPCRC) in patients with prostate cancer undergoing RT has not been adequately studied.
METHODS: This study employed a population-based cohort design using the US Surveillance, Epidemiology, and End Results (SEER) database to identify individuals diagnosed between January 1975 and December 2015. The cumulative incidence of SPCRC was estimated using Fine-Gray competing risk regression. Poisson regression analysis was used to estimate the risk associated with RT. Survival outcomes of patients with SPCRC were evaluated using the Kaplan-Meier method.
RESULTS: A total of 287,607 patients diagnosed with prostate cancer were identified. The cumulative incidences were higher in patients who did not receive RT (2.00%) compared to those who underwent RT (2.47%) after 25 years. After adjustment for multiple variables, RT was associated with an increased risk of developing combined SPCRC (adjusted HR 1.590). Additionally, the overall survival was significantly lower in patients who developed colorectal cancer after receiving RT as compared to those who did not receive RT.
CONCLUSION: These findings underscore the need for diligent long-term monitoring and effective management strategies to detect SPCRC in patients treated with RT for prostate cancer.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:28 |
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| Enthalten in: |
Techniques in coloproctology - 28(2023), 1 vom: 14. Dez., Seite 14 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tang, W [VerfasserIn] |
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| Links: |
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| Themen: |
Colorectal cancer |
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| Anmerkungen: |
Date Completed 16.12.2023 Date Revised 06.02.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s10151-023-02883-2 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM365864811 |
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| 500 | |a Date Revised 06.02.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. Springer Nature Switzerland AG. | ||
| 520 | |a BACKGROUND: Radiotherapy (RT) is a common treatment for prostate cancer, yet the risk of second primary colorectal cancer (SPCRC) in patients with prostate cancer undergoing RT has not been adequately studied | ||
| 520 | |a METHODS: This study employed a population-based cohort design using the US Surveillance, Epidemiology, and End Results (SEER) database to identify individuals diagnosed between January 1975 and December 2015. The cumulative incidence of SPCRC was estimated using Fine-Gray competing risk regression. Poisson regression analysis was used to estimate the risk associated with RT. Survival outcomes of patients with SPCRC were evaluated using the Kaplan-Meier method | ||
| 520 | |a RESULTS: A total of 287,607 patients diagnosed with prostate cancer were identified. The cumulative incidences were higher in patients who did not receive RT (2.00%) compared to those who underwent RT (2.47%) after 25 years. After adjustment for multiple variables, RT was associated with an increased risk of developing combined SPCRC (adjusted HR 1.590). Additionally, the overall survival was significantly lower in patients who developed colorectal cancer after receiving RT as compared to those who did not receive RT | ||
| 520 | |a CONCLUSION: These findings underscore the need for diligent long-term monitoring and effective management strategies to detect SPCRC in patients treated with RT for prostate cancer | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Colorectal cancer | |
| 650 | 4 | |a Prostate cancer | |
| 650 | 4 | |a Radiotherapy | |
| 650 | 4 | |a SEER | |
| 650 | 4 | |a Second primary cancer | |
| 650 | 4 | |a Survival analysis | |
| 700 | 1 | |a Zhou, L-J |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, W-Q |e verfasserin |4 aut | |
| 700 | 1 | |a Jia, Y-J |e verfasserin |4 aut | |
| 700 | 1 | |a Ge, M-W |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, F-H |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, H-L |e verfasserin |4 aut | |
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