Dual-target inhibitors based on COX-2 : a review from medicinal chemistry perspectives
Inhibitors of COX-2 constitute a class of anti-inflammatory analgesics, showing potential against certain types of cancer. However, such inhibitors are associated with cardiovascular toxicity. Moreover, although single-target molecules possess specificity for particular targets, they often lead to poor safety, low efficacy and drug resistance due to compensatory mechanisms. A new generation of dual-target drugs that simultaneously inhibit COX-2 and another target is showing strong potential to treat cancer or reduce adverse cardiac effects. The present perspective focuses on the structure and functions of COX-2, and its role as a therapeutic target. It also explores the current state and future possibilities for dual-target strategies from a medicinal chemistry perspective.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2023 |
---|---|
Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
---|---|
Enthalten in: |
Future medicinal chemistry - 15(2023), 23 vom: 21. Dez., Seite 2209-2233 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Zhang, Fengmei [VerfasserIn] |
---|
Links: |
---|
Themen: |
Antineoplastic Agents |
---|
Anmerkungen: |
Date Completed 22.02.2024 Date Revised 22.02.2024 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.4155/fmc-2023-0192 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM365857815 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM365857815 | ||
003 | DE-627 | ||
005 | 20240229143940.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2023 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.4155/fmc-2023-0192 |2 doi | |
028 | 5 | 2 | |a pubmed24n1303.xml |
035 | |a (DE-627)NLM365857815 | ||
035 | |a (NLM)38095081 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Zhang, Fengmei |e verfasserin |4 aut | |
245 | 1 | 0 | |a Dual-target inhibitors based on COX-2 |b a review from medicinal chemistry perspectives |
264 | 1 | |c 2023 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 22.02.2024 | ||
500 | |a Date Revised 22.02.2024 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Inhibitors of COX-2 constitute a class of anti-inflammatory analgesics, showing potential against certain types of cancer. However, such inhibitors are associated with cardiovascular toxicity. Moreover, although single-target molecules possess specificity for particular targets, they often lead to poor safety, low efficacy and drug resistance due to compensatory mechanisms. A new generation of dual-target drugs that simultaneously inhibit COX-2 and another target is showing strong potential to treat cancer or reduce adverse cardiac effects. The present perspective focuses on the structure and functions of COX-2, and its role as a therapeutic target. It also explores the current state and future possibilities for dual-target strategies from a medicinal chemistry perspective | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Review | |
650 | 4 | |a COX-2 | |
650 | 4 | |a drug design | |
650 | 4 | |a dual-target inhibitor | |
650 | 4 | |a structure–activity relationship | |
650 | 7 | |a Antineoplastic Agents |2 NLM | |
650 | 7 | |a Cyclooxygenase 2 |2 NLM | |
650 | 7 | |a EC 1.14.99.1 |2 NLM | |
650 | 7 | |a Cyclooxygenase 2 Inhibitors |2 NLM | |
700 | 1 | |a Zhu, Guonian |e verfasserin |4 aut | |
700 | 1 | |a Li, Yangqian |e verfasserin |4 aut | |
700 | 1 | |a Qi, Yawen |e verfasserin |4 aut | |
700 | 1 | |a Wang, Zhoufeng |e verfasserin |4 aut | |
700 | 1 | |a Li, Weimin |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Future medicinal chemistry |d 2009 |g 15(2023), 23 vom: 21. Dez., Seite 2209-2233 |w (DE-627)NLM194822109 |x 1756-8927 |7 nnns |
773 | 1 | 8 | |g volume:15 |g year:2023 |g number:23 |g day:21 |g month:12 |g pages:2209-2233 |
856 | 4 | 0 | |u http://dx.doi.org/10.4155/fmc-2023-0192 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 15 |j 2023 |e 23 |b 21 |c 12 |h 2209-2233 |