Hierarchical Mechanical Transduction of Precision-Engineered DNA Hydrogels with Sacrificial Bonds
Engineering the response to external signals in mechanically switchable hydrogels is important to promote smart materials applications. However, comparably little attention has focused on embedded precision mechanisms for autonomous nonlinear response in mechanical profiles in hydrogels, and we lack understanding of how the behavior from the molecular scale transduces to the macroscale. Here, we design a nonlinear stress-strain response into hydrogels by engineering sacrificial DNA hairpin loops into model network hydrogels formed from star-shaped building blocks. We characterize the force-extension response of single DNA hairpins and are able to describe how the specific topology influences the nonlinear mechanical behavior at different length scales. For this purpose, we utilize force spectroscopy as well as microscopic and macroscopic deformation tests. This study contributes to a better understanding of designing nonlinear strain-adaptive features into hydrogel materials.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
|---|---|
| Enthalten in: |
ACS applied materials & interfaces - 15(2023), 51 vom: 27. Dez., Seite 59714-59721 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Lallemang, Max [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
9007-49-2 |
|---|
| Anmerkungen: |
Date Completed 28.12.2023 Date Revised 28.12.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1021/acsami.3c15135 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM365857742 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM365857742 | ||
| 003 | DE-627 | ||
| 005 | 20231229124225.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1021/acsami.3c15135 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1241.xml |
| 035 | |a (DE-627)NLM365857742 | ||
| 035 | |a (NLM)38095074 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Lallemang, Max |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Hierarchical Mechanical Transduction of Precision-Engineered DNA Hydrogels with Sacrificial Bonds |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 28.12.2023 | ||
| 500 | |a Date Revised 28.12.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Engineering the response to external signals in mechanically switchable hydrogels is important to promote smart materials applications. However, comparably little attention has focused on embedded precision mechanisms for autonomous nonlinear response in mechanical profiles in hydrogels, and we lack understanding of how the behavior from the molecular scale transduces to the macroscale. Here, we design a nonlinear stress-strain response into hydrogels by engineering sacrificial DNA hairpin loops into model network hydrogels formed from star-shaped building blocks. We characterize the force-extension response of single DNA hairpins and are able to describe how the specific topology influences the nonlinear mechanical behavior at different length scales. For this purpose, we utilize force spectroscopy as well as microscopic and macroscopic deformation tests. This study contributes to a better understanding of designing nonlinear strain-adaptive features into hydrogel materials | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a AFM | |
| 650 | 4 | |a DNA | |
| 650 | 4 | |a hydrogel | |
| 650 | 4 | |a nonlinear response | |
| 650 | 4 | |a single molecule studies | |
| 650 | 7 | |a Hydrogels |2 NLM | |
| 650 | 7 | |a DNA |2 NLM | |
| 650 | 7 | |a 9007-49-2 |2 NLM | |
| 650 | 7 | |a Smart Materials |2 NLM | |
| 700 | 1 | |a Akintayo, Cecilia Oluwadunsin |e verfasserin |4 aut | |
| 700 | 1 | |a Wenzel, Christiane |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Weixiang |e verfasserin |4 aut | |
| 700 | 1 | |a Sielaff, Lucca |e verfasserin |4 aut | |
| 700 | 1 | |a Ripp, Alexander |e verfasserin |4 aut | |
| 700 | 1 | |a Jessen, Henning J |e verfasserin |4 aut | |
| 700 | 1 | |a Balzer, Bizan N |e verfasserin |4 aut | |
| 700 | 1 | |a Walther, Andreas |e verfasserin |4 aut | |
| 700 | 1 | |a Hugel, Thorsten |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t ACS applied materials & interfaces |d 2009 |g 15(2023), 51 vom: 27. Dez., Seite 59714-59721 |w (DE-627)NLM194100049 |x 1944-8252 |7 nnns |
| 773 | 1 | 8 | |g volume:15 |g year:2023 |g number:51 |g day:27 |g month:12 |g pages:59714-59721 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1021/acsami.3c15135 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 15 |j 2023 |e 51 |b 27 |c 12 |h 59714-59721 | ||