Puzzles, challenges, and information reservoir of SARS-CoV-2 quasispecies
Upon the emergence of SARS-CoV-2 in the human population, it was conjectured that for this coronavirus the dynamic intra-host heterogeneity typical of RNA viruses would be toned down. Nothing of this sort is observed. Here we review the main observations on the complexity and diverse composition of SARS-CoV-2 mutant spectra sampled from infected patients, within the framework of quasispecies dynamics. The analyses suggest that the information provided by myriads of genomic sequences within infected individuals may have a predictive value of the genomic sequences that acquire epidemiological relevance. Possibilities to reconcile the presence of broad mutant spectra in the large RNA coronavirus genome with its encoding a 3' to 5' exonuclease proofreading-repair activity are considered. Indeterminations in the behavior of individual viral genomes provide a benefit for the survival of the ensemble. We propose that this concept falls in the domain of "stochastic thinking," a notion that applies also to cellular processes, as a means for biological systems to face unexpected needs.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:97 |
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| Enthalten in: |
Journal of virology - 97(2023), 12 vom: 21. Dez., Seite e0151123 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Domingo, Esteban [VerfasserIn] |
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| Links: |
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| Themen: |
Cancer heterogeneity |
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| Anmerkungen: |
Date Completed 04.01.2024 Date Revised 04.01.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1128/jvi.01511-23 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM365833630 |
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| 520 | |a Upon the emergence of SARS-CoV-2 in the human population, it was conjectured that for this coronavirus the dynamic intra-host heterogeneity typical of RNA viruses would be toned down. Nothing of this sort is observed. Here we review the main observations on the complexity and diverse composition of SARS-CoV-2 mutant spectra sampled from infected patients, within the framework of quasispecies dynamics. The analyses suggest that the information provided by myriads of genomic sequences within infected individuals may have a predictive value of the genomic sequences that acquire epidemiological relevance. Possibilities to reconcile the presence of broad mutant spectra in the large RNA coronavirus genome with its encoding a 3' to 5' exonuclease proofreading-repair activity are considered. Indeterminations in the behavior of individual viral genomes provide a benefit for the survival of the ensemble. We propose that this concept falls in the domain of "stochastic thinking," a notion that applies also to cellular processes, as a means for biological systems to face unexpected needs | ||
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| 700 | 1 | |a Martínez-González, Brenda |e verfasserin |4 aut | |
| 700 | 1 | |a García-Crespo, Carlos |e verfasserin |4 aut | |
| 700 | 1 | |a Somovilla, Pilar |e verfasserin |4 aut | |
| 700 | 1 | |a de Ávila, Ana Isabel |e verfasserin |4 aut | |
| 700 | 1 | |a Soria, María Eugenia |e verfasserin |4 aut | |
| 700 | 1 | |a Durán-Pastor, Antoni |e verfasserin |4 aut | |
| 700 | 1 | |a Perales, Celia |e verfasserin |4 aut | |
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