Correlation of serum VEGF-C, ANGPTL4, and activin A levels with frailty
Copyright © 2023. Published by Elsevier Inc..
BACKGROUND: Secretory factors linked to lymphogenesis, such as vascular endothelial growth factor C (VEGF-C), angiopoietin like protein 4 (ANGPTL4), and activin A (ACV-A), have been recognized as potential markers of chronic inflammatory status and age-related diseases. Furthermore, these factors may also be linked to frailty. The primary objective of this study was to examine the serum VEGF-C, ANGPTL4, and ACV-A levels in young individuals, healthy older individuals, and older individuals with pre-frailty and frailty, and to determine their association with pro-inflammatory factor levels.
METHODS: We conducted an observational study, enrolling a total of 210 older individuals and 20 young healthy volunteers. Participants were divided into four groups based on the Freid frailty phenotype: healthy young group, older patients without frailty group, pre-frail older group, and frail older group. Plasma and peripheral blood mononuclear cells (PBMCs) were collected from all four groups. ELISA was used to measure the serum levels of VEGF-C, ANGPTL4, ACV-A, and pro-inflammatory cytokines, while RT-qPCR was used to measure the transcription level of VEGF-C, ANGPTL4 and ACV-A in PBMCs.
RESULTS: In comparison to healthy young individuals and older participants without frailty, older participants with frailty exhibited lower renal function, higher serum levels and transcription levels of VEGF-C, ANGPTL4, ACV-A, and elevated levels of pro-inflammatory cytokines (CRP, IL-1β, and TNF-α). Multiple linear regression analysis revealed that serum levels of VEGF-C, ANGPTL4, and ACV-A were positively correlated with the frailty index, independent of age, eGFR, and comorbidities. Furthermore, the receiver operating characteristic (ROC) curve analysis demonstrated that serum levels of VEGF-C, ANGPTL4, and ACV-A have great accuracy in predicting frailty.
CONCLUSION: Elevated serum levels of VEGF-C, ANGPTL4, and ACV-A are associated with frailty status.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:185 |
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| Enthalten in: |
Experimental gerontology - 185(2024) vom: 01. Jan., Seite 112345 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Chang, Hung-Chen [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 10.01.2024 Date Revised 21.01.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.exger.2023.112345 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 100 | 1 | |a Chang, Hung-Chen |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Correlation of serum VEGF-C, ANGPTL4, and activin A levels with frailty |
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| 500 | |a Date Revised 21.01.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023. Published by Elsevier Inc. | ||
| 520 | |a BACKGROUND: Secretory factors linked to lymphogenesis, such as vascular endothelial growth factor C (VEGF-C), angiopoietin like protein 4 (ANGPTL4), and activin A (ACV-A), have been recognized as potential markers of chronic inflammatory status and age-related diseases. Furthermore, these factors may also be linked to frailty. The primary objective of this study was to examine the serum VEGF-C, ANGPTL4, and ACV-A levels in young individuals, healthy older individuals, and older individuals with pre-frailty and frailty, and to determine their association with pro-inflammatory factor levels | ||
| 520 | |a METHODS: We conducted an observational study, enrolling a total of 210 older individuals and 20 young healthy volunteers. Participants were divided into four groups based on the Freid frailty phenotype: healthy young group, older patients without frailty group, pre-frail older group, and frail older group. Plasma and peripheral blood mononuclear cells (PBMCs) were collected from all four groups. ELISA was used to measure the serum levels of VEGF-C, ANGPTL4, ACV-A, and pro-inflammatory cytokines, while RT-qPCR was used to measure the transcription level of VEGF-C, ANGPTL4 and ACV-A in PBMCs | ||
| 520 | |a RESULTS: In comparison to healthy young individuals and older participants without frailty, older participants with frailty exhibited lower renal function, higher serum levels and transcription levels of VEGF-C, ANGPTL4, ACV-A, and elevated levels of pro-inflammatory cytokines (CRP, IL-1β, and TNF-α). Multiple linear regression analysis revealed that serum levels of VEGF-C, ANGPTL4, and ACV-A were positively correlated with the frailty index, independent of age, eGFR, and comorbidities. Furthermore, the receiver operating characteristic (ROC) curve analysis demonstrated that serum levels of VEGF-C, ANGPTL4, and ACV-A have great accuracy in predicting frailty | ||
| 520 | |a CONCLUSION: Elevated serum levels of VEGF-C, ANGPTL4, and ACV-A are associated with frailty status | ||
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a ANGPTL4 | |
| 650 | 4 | |a Activin a | |
| 650 | 4 | |a Frailty | |
| 650 | 4 | |a Pro-inflammatory cytokines | |
| 650 | 4 | |a VEGF-C | |
| 650 | 7 | |a activin A |2 NLM | |
| 650 | 7 | |a Angiopoietin-Like Protein 4 |2 NLM | |
| 650 | 7 | |a ANGPTL4 protein, human |2 NLM | |
| 650 | 7 | |a Cytokines |2 NLM | |
| 650 | 7 | |a Vascular Endothelial Growth Factor C |2 NLM | |
| 650 | 7 | |a VEGFC protein, human |2 NLM | |
| 700 | 1 | |a Wang, Xiaojun |e verfasserin |4 aut | |
| 700 | 1 | |a Gu, Xuchao |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Shuai |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Wenhao |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Tao |e verfasserin |4 aut | |
| 700 | 1 | |a Ye, Maoqing |e verfasserin |4 aut | |
| 700 | 1 | |a Qu, Xinkai |e verfasserin |4 aut | |
| 700 | 1 | |a Bao, Zhijun |e verfasserin |4 aut | |
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