Altered glucagon and GLP-1 responses to oral glucose in children and adolescents with obesity and insulin resistance
© The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society..
CONTEXT: Pediatric obesity is characterized by insulin resistance, yet it remains unclear whether insulin resistance contributes to abnormalities in glucagon and incretin secretion.
OBJECTIVE: To examine whether fasting and stimulated glucagon, GLP-1, and GIP concentrations differ between children and adolescents with obesity and insulin resistance (OIR), obesity and normal insulin sensitivity (OIS), and controls with normal weight (NW).
METHODS: 80 (34 boys) children and adolescents, aged 7-17 years with OIR (n=22), OIS (n=22), and NW (n=36) underwent an oral glucose tolerance test with measurements of serum insulin, plasma glucose, glucagon, total GLP-1, and total GIP. Homeostatic model assessment of insulin resistance (HOMA-IR), single point insulin sensitivity estimator (SPISE), Matsuda index, insulinogenic index (IGI), and oral disposition index (ODI) were calculated.
RESULTS: Fasting concentrations of glucagon and GLP-1 were higher in the OIR-group, with no significant differences for GIP. The OIR-group had higher glucagon total area under the curve (tAUC0-120) and lower GLP-1 incremental AUC (iAUC0-120), with no significant differences for GIP iAUC0-120. Higher fasting glucagon was associated with higher HOMA-IR, lower Matsuda index, lower SPISE, higher IGI, and higher plasma alanine transaminase, whereas higher fasting GLP-1 was associated with higher HOMA-IR, lower Matsuda index, and lower ODI. Higher glucagon tAUC0-120 was associated lower SPISE and lower Matsuda index, whereas lower GLP-1 iAUC0-120 was associated with a higher HOMA-IR, lower Matsuda index, and lower ODI.
CONCLUSIONS: The OIR-group had elevated fasting concentrations of glucagon and GLP-1, and higher glucagon, but lower GLP-1 responses during an OGTT compared to the OIS- and NW-groups. In contrast, the OIS-group had similar hormone responses to the NW-group.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2023 |
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| Enthalten in: |
The Journal of clinical endocrinology and metabolism - (2023) vom: 13. Dez. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Stinson, Sara Elizabeth [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Revised 13.12.2023 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1210/clinem/dgad728 |
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| Förderinstitution / Projekttitel: |
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NLM365786594 |
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| 100 | 1 | |a Stinson, Sara Elizabeth |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Altered glucagon and GLP-1 responses to oral glucose in children and adolescents with obesity and insulin resistance |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
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| 500 | |a Date Revised 13.12.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a © The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society. | ||
| 520 | |a CONTEXT: Pediatric obesity is characterized by insulin resistance, yet it remains unclear whether insulin resistance contributes to abnormalities in glucagon and incretin secretion | ||
| 520 | |a OBJECTIVE: To examine whether fasting and stimulated glucagon, GLP-1, and GIP concentrations differ between children and adolescents with obesity and insulin resistance (OIR), obesity and normal insulin sensitivity (OIS), and controls with normal weight (NW) | ||
| 520 | |a METHODS: 80 (34 boys) children and adolescents, aged 7-17 years with OIR (n=22), OIS (n=22), and NW (n=36) underwent an oral glucose tolerance test with measurements of serum insulin, plasma glucose, glucagon, total GLP-1, and total GIP. Homeostatic model assessment of insulin resistance (HOMA-IR), single point insulin sensitivity estimator (SPISE), Matsuda index, insulinogenic index (IGI), and oral disposition index (ODI) were calculated | ||
| 520 | |a RESULTS: Fasting concentrations of glucagon and GLP-1 were higher in the OIR-group, with no significant differences for GIP. The OIR-group had higher glucagon total area under the curve (tAUC0-120) and lower GLP-1 incremental AUC (iAUC0-120), with no significant differences for GIP iAUC0-120. Higher fasting glucagon was associated with higher HOMA-IR, lower Matsuda index, lower SPISE, higher IGI, and higher plasma alanine transaminase, whereas higher fasting GLP-1 was associated with higher HOMA-IR, lower Matsuda index, and lower ODI. Higher glucagon tAUC0-120 was associated lower SPISE and lower Matsuda index, whereas lower GLP-1 iAUC0-120 was associated with a higher HOMA-IR, lower Matsuda index, and lower ODI | ||
| 520 | |a CONCLUSIONS: The OIR-group had elevated fasting concentrations of glucagon and GLP-1, and higher glucagon, but lower GLP-1 responses during an OGTT compared to the OIS- and NW-groups. In contrast, the OIS-group had similar hormone responses to the NW-group | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Adolescent | |
| 650 | 4 | |a Child | |
| 650 | 4 | |a GIP | |
| 650 | 4 | |a GLP-1 | |
| 650 | 4 | |a Glucagon | |
| 650 | 4 | |a Obesity | |
| 700 | 1 | |a Fernández de Retana Alzola, Ierai |e verfasserin |4 aut | |
| 700 | 1 | |a Brünner Hovendal, Emilie Damgaard |e verfasserin |4 aut | |
| 700 | 1 | |a Lund, Morten Asp Vonsild |e verfasserin |4 aut | |
| 700 | 1 | |a Fonvig, Cilius Esmann |e verfasserin |4 aut | |
| 700 | 1 | |a Holm, Louise Aas |e verfasserin |4 aut | |
| 700 | 1 | |a Jonsson, Anna Elisabet |e verfasserin |4 aut | |
| 700 | 1 | |a Frithioff-Bøjsøe, Christine |e verfasserin |4 aut | |
| 700 | 1 | |a Christiansen, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Pedersen, Oluf |e verfasserin |4 aut | |
| 700 | 1 | |a Ängquist, Lars |e verfasserin |4 aut | |
| 700 | 1 | |a Sørensen, Thorkild I A |e verfasserin |4 aut | |
| 700 | 1 | |a Holst, Jens Juul |e verfasserin |4 aut | |
| 700 | 1 | |a Hartmann, Bolette |e verfasserin |4 aut | |
| 700 | 1 | |a Holm, Jens-Christian |e verfasserin |4 aut | |
| 700 | 1 | |a Hansen, Torben |e verfasserin |4 aut | |
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