Colorectal cancer recurrence and its impact on survival after curative surgery : An analysis based on multistate models
Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved..
AIM: To investigate the usefulness of multistate models (MSM) for determining colorectal cancer (CRC) recurrence rate, to analyse the effect of different factors on tumour recurrence and death, and to assess the impact of recurrence for CRC prognosis.
METHODS: Observational follow-up study of incident CRC cases disease-free after curative resection in 2006-2013 (n = 994). Recurrence and mortality were analyzed with MSM, as well as covariate effects on transition probabilities.
RESULTS: Cumulative incidence of recurrence at 60 months was 13.7%. Five years after surgery, 70.3% of patients were alive and recurrence-free, and 8.4% were alive after recurrence. Recurrence has a negative impact on prognosis, with 5-year CRC-related mortality increasing from 3.8% for those who are recurrence-free 1-year after surgery to 33.6% for those with a recurrence. Advanced stage increases recurrence risk (HR = 1.53) and CRC-related mortality after recurrence (HR = 2.35). CRC-related death was associated with age in recurrence-free patients, and with comorbidity after recurrence. As expected, age≥75 years was a risk factor for non-CRC-related death with (HR = 7.76) or without recurrence (HR = 4.26), while its effect on recurrence risk was not demonstrated.
CONCLUSIONS: MSM allows detailed analysis of recurrence and mortality in CRC. Recurrence has a negative impact on prognosis. Advanced stage was a determining factor for recurrence and CRC-death after recurrence.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2023 |
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| Enthalten in: |
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver - (2023) vom: 11. Dez. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Balboa-Barreiro, Vanesa [VerfasserIn] |
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| Links: |
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| Themen: |
Colorectal neoplasms |
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| Anmerkungen: |
Date Revised 13.12.2023 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1016/j.dld.2023.11.041 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM365784079 |
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| 100 | 1 | |a Balboa-Barreiro, Vanesa |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Colorectal cancer recurrence and its impact on survival after curative surgery |b An analysis based on multistate models |
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| 500 | |a Date Revised 13.12.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved. | ||
| 520 | |a AIM: To investigate the usefulness of multistate models (MSM) for determining colorectal cancer (CRC) recurrence rate, to analyse the effect of different factors on tumour recurrence and death, and to assess the impact of recurrence for CRC prognosis | ||
| 520 | |a METHODS: Observational follow-up study of incident CRC cases disease-free after curative resection in 2006-2013 (n = 994). Recurrence and mortality were analyzed with MSM, as well as covariate effects on transition probabilities | ||
| 520 | |a RESULTS: Cumulative incidence of recurrence at 60 months was 13.7%. Five years after surgery, 70.3% of patients were alive and recurrence-free, and 8.4% were alive after recurrence. Recurrence has a negative impact on prognosis, with 5-year CRC-related mortality increasing from 3.8% for those who are recurrence-free 1-year after surgery to 33.6% for those with a recurrence. Advanced stage increases recurrence risk (HR = 1.53) and CRC-related mortality after recurrence (HR = 2.35). CRC-related death was associated with age in recurrence-free patients, and with comorbidity after recurrence. As expected, age≥75 years was a risk factor for non-CRC-related death with (HR = 7.76) or without recurrence (HR = 4.26), while its effect on recurrence risk was not demonstrated | ||
| 520 | |a CONCLUSIONS: MSM allows detailed analysis of recurrence and mortality in CRC. Recurrence has a negative impact on prognosis. Advanced stage was a determining factor for recurrence and CRC-death after recurrence | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Colorectal neoplasms | |
| 650 | 4 | |a Models, statistical | |
| 650 | 4 | |a Neoplasm recurrence | |
| 650 | 4 | |a Prognosis | |
| 700 | 1 | |a Pértega-Díaz, Sonia |e verfasserin |4 aut | |
| 700 | 1 | |a García-Rodríguez, Teresa |e verfasserin |4 aut | |
| 700 | 1 | |a González-Martín, Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Pardeiro-Pértega, Remedios |e verfasserin |4 aut | |
| 700 | 1 | |a Yáñez-González-Dopeso, Loreto |e verfasserin |4 aut | |
| 700 | 1 | |a Seoane-Pillado, Teresa |e verfasserin |4 aut | |
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