Changes in Anticholinergic Burden in Parkinson's Disease After Deep Brain Stimulation
Copyright © 2023 International Neuromodulation Society. All rights reserved..
OBJECTIVE: This study aimed to evaluate the effect of deep brain stimulation (DBS) on anticholinergic burden in Parkinson's disease (PD) and the association of anticholinergic burden with cognition.
MATERIALS AND METHODS: A retrospective chart review in patients with PD who underwent bilateral subthalamic nucleus (STN) or globus pallidus internus (GPi) DBS from 2010 to 2020 reviewed medications with anticholinergic burden at baseline, six months, and one year (N = 216) after surgery. The cumulative anticholinergic burden at each visit was calculated using the Anticholinergic Risk Scale (ARS).
RESULTS: ARS scores were significantly lower for patients six months and one year after surgery than at baseline (z = 6.58, p < 0.0001; z = 6.99, p < 0.0001). Change in ARS scores at both six months and one year were driven by down-titration of PD medications (z = 9.35, p < 0.0001; z = 8.61, p < 0.0001), rather than changes in pain, psychiatric, or urinary medications with anticholinergic effects. There was no significant difference in change in ARS scores at one year between targets (t = 0.41, p = 0.68). In addition, there was no significant association between anticholinergic burden and cognitive performance.
CONCLUSION: GPi and STN DBS are associated with decreased anticholinergic burden due to PD medications in the first year after surgery.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:27 |
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| Enthalten in: |
Neuromodulation : journal of the International Neuromodulation Society - 27(2024), 3 vom: 01. Apr., Seite 538-543 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Jiao, Jocelyn [VerfasserIn] |
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| Links: |
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| Themen: |
Anticholinergic medication burden |
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| Anmerkungen: |
Date Completed 05.04.2024 Date Revised 05.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.neurom.2023.11.001 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM365759473 |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 International Neuromodulation Society. All rights reserved. | ||
| 520 | |a OBJECTIVE: This study aimed to evaluate the effect of deep brain stimulation (DBS) on anticholinergic burden in Parkinson's disease (PD) and the association of anticholinergic burden with cognition | ||
| 520 | |a MATERIALS AND METHODS: A retrospective chart review in patients with PD who underwent bilateral subthalamic nucleus (STN) or globus pallidus internus (GPi) DBS from 2010 to 2020 reviewed medications with anticholinergic burden at baseline, six months, and one year (N = 216) after surgery. The cumulative anticholinergic burden at each visit was calculated using the Anticholinergic Risk Scale (ARS) | ||
| 520 | |a RESULTS: ARS scores were significantly lower for patients six months and one year after surgery than at baseline (z = 6.58, p < 0.0001; z = 6.99, p < 0.0001). Change in ARS scores at both six months and one year were driven by down-titration of PD medications (z = 9.35, p < 0.0001; z = 8.61, p < 0.0001), rather than changes in pain, psychiatric, or urinary medications with anticholinergic effects. There was no significant difference in change in ARS scores at one year between targets (t = 0.41, p = 0.68). In addition, there was no significant association between anticholinergic burden and cognitive performance | ||
| 520 | |a CONCLUSION: GPi and STN DBS are associated with decreased anticholinergic burden due to PD medications in the first year after surgery | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Anticholinergic medication burden | |
| 650 | 4 | |a Parkinson’s disease | |
| 650 | 4 | |a anticholinergic side effects | |
| 650 | 4 | |a cognitive decline | |
| 650 | 4 | |a deep brain stimulation | |
| 650 | 7 | |a Cholinergic Antagonists |2 NLM | |
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| 700 | 1 | |a Hantke, Nathan |e verfasserin |4 aut | |
| 700 | 1 | |a Wilhelmi, Morgan |e verfasserin |4 aut | |
| 700 | 1 | |a Bonilla, Christian |e verfasserin |4 aut | |
| 700 | 1 | |a Safarpour, Delaram |e verfasserin |4 aut | |
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