Clinical significance of total nucleated cell count in bone marrow of patients with acute lymphoblastic leukemia who underwent allogeneic hematopoietic stem cell transplantation
© 2023. Japanese Society of Hematology..
The clinical implications of recipient bone marrow nucleated cell count (NCC) prior to allogeneic hematopoietic stem cell transplantation (allo-HSCT) remain unknown. We conducted a multicenter retrospective study to evaluate the clinical significance of bone marrow NCC prior to allo-HSCT in patients with acute lymphoblastic leukemia. Patients who were in remission and underwent the initial allo-HSCT were included and stratified into high- and low-NCC groups using an NCC of 10 × 104/µL as the cut-off. The 3-year overall survival (OS), non-relapse mortality (NRM), and relapse rates for the high- and low-NCC groups were 51.2 vs. 84.5% (p < 0.001), 27.5 vs. 6.5% (p < 0.001), and 31.1 vs. 24.4% (p = 0.322), respectively. The high-NCC group had significantly poorer OS and higher NRM when compared with the low-NCC group. In summary, high recipient bone marrow NCC is associated with higher NRM and lower OS following allo-HSCT.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:119 |
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| Enthalten in: |
International journal of hematology - 119(2024), 1 vom: 09. Jan., Seite 62-70 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Nukui, Jun [VerfasserIn] |
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| Links: |
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| Themen: |
Acute lymphoblastic leukemia |
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| Anmerkungen: |
Date Completed 08.01.2024 Date Revised 08.01.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s12185-023-03688-7 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM365729647 |
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| 245 | 1 | 0 | |a Clinical significance of total nucleated cell count in bone marrow of patients with acute lymphoblastic leukemia who underwent allogeneic hematopoietic stem cell transplantation |
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| 520 | |a © 2023. Japanese Society of Hematology. | ||
| 520 | |a The clinical implications of recipient bone marrow nucleated cell count (NCC) prior to allogeneic hematopoietic stem cell transplantation (allo-HSCT) remain unknown. We conducted a multicenter retrospective study to evaluate the clinical significance of bone marrow NCC prior to allo-HSCT in patients with acute lymphoblastic leukemia. Patients who were in remission and underwent the initial allo-HSCT were included and stratified into high- and low-NCC groups using an NCC of 10 × 104/µL as the cut-off. The 3-year overall survival (OS), non-relapse mortality (NRM), and relapse rates for the high- and low-NCC groups were 51.2 vs. 84.5% (p < 0.001), 27.5 vs. 6.5% (p < 0.001), and 31.1 vs. 24.4% (p = 0.322), respectively. The high-NCC group had significantly poorer OS and higher NRM when compared with the low-NCC group. In summary, high recipient bone marrow NCC is associated with higher NRM and lower OS following allo-HSCT | ||
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Acute lymphoblastic leukemia | |
| 650 | 4 | |a Allogeneic hematopoietic stem cell transplantation | |
| 650 | 4 | |a Nucleated cell count | |
| 700 | 1 | |a Tachibana, Takayoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Miyazaki, Takuya |e verfasserin |4 aut | |
| 700 | 1 | |a Tanaka, Masatsugu |e verfasserin |4 aut | |
| 700 | 1 | |a Matsumoto, Kenji |e verfasserin |4 aut | |
| 700 | 1 | |a Ishii, Yoshimi |e verfasserin |4 aut | |
| 700 | 1 | |a Numata, Ayumi |e verfasserin |4 aut | |
| 700 | 1 | |a Nakajima, Yuki |e verfasserin |4 aut | |
| 700 | 1 | |a Matsumura, Ayako |e verfasserin |4 aut | |
| 700 | 1 | |a Suzuki, Taisei |e verfasserin |4 aut | |
| 700 | 1 | |a Izumi, Akihiko |e verfasserin |4 aut | |
| 700 | 1 | |a Hirose, Natsuki |e verfasserin |4 aut | |
| 700 | 1 | |a Yamamoto, Koji |e verfasserin |4 aut | |
| 700 | 1 | |a Hagihara, Maki |e verfasserin |4 aut | |
| 700 | 1 | |a Fujisawa, Shin |e verfasserin |4 aut | |
| 700 | 1 | |a Kanamori, Heiwa |e verfasserin |4 aut | |
| 700 | 1 | |a Nakajima, Hideaki |e verfasserin |4 aut | |
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