Microperimetric evaluation and predictive factors of visual recovery after successful inverted internal limiting membrane-flap technique for macular hole in high myopic eyes
Copyright © 2023 Sborgia, Boscia, Niro, Landini, Pastore, Albano, Piepoli, Donghia, Dore, Viggiano, Buonamassa, Di Pardo, Molfetta, Eye Clinic Research Group, Coassin, Dell’Omo, Boscia, Alessio and Sborgia..
Introduction: Inverted Internal Limiting Membrane (ILM)-flap technique demonstrated its effectiveness, in terms of anatomical closure rate and visual acuity recovery for high myopic macular holes. We evaluated macular function after a successful inverted ILM-flap for macular holes in high myopic eyes (hMMH) using microperimetry to predict visual prognosis.
Methods: A retrospective study on 23 eyes of 23 patients after surgical closure of hMMH, was performed. All patients underwent inverted ILM-flap and gas tamponade. Cataract surgery was performed in phakic eyes. Study outcomes including best-corrected visual acuity (BCVA), retinal sensitivity (RS) at central 12°, central retinal sensitivity (CRS) at central 4° and mean deviation (MD), and fixation behavior as bivariate contour ellipse area (BCEA, degrees2) measured by microperimetry, were evaluated over 6 months. A mixed-effects model was used to evaluate and compare the repeated measurements of outcomes between phakic and pseudophakic eyes. A regression model was performed to assess the relationship between BCVA at 6 months and independent variables.
Results: Overall mean BCVA improved from 0.98 ± 0.21 logMAR at baseline to 0.47 ± 0.31 logMAR at the last follow-up (p < 0.001). Over 6 months, overall sensitivity measurements improved (RS, p = 0.001; CRS, p < 0.0001; MD, p = 0.03), and the BCEA decreased in dimension, although not significantly (p ≥ 0.05). The mixed model revealed a significantly better effect of inverted ILM-flap combined with cataract surgery on BCVA and CRS in phakic eyes than inverted ILM-flap alone in pseudophakic ones. The regression model revealed a relationship of 6-month BCVA with pre-operative BCVA (β = 0.60, p = 0.02) and RS (β = -0.03, p = 0.01).
Conclusion: The inverted ILM-flap technique significantly improved visual acuity and retinal sensitivity after the hMMH closure, particularly when combined with cataract extraction. Pre-operative visual acuity and retinal sensitivity at central 12° may predict post-surgical visual acuity.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
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| Enthalten in: |
Frontiers in medicine - 10(2023) vom: 19., Seite 1276502 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sborgia, Alessandra [VerfasserIn] |
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| Links: |
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| Themen: |
Axial length |
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| Anmerkungen: |
Date Revised 11.12.2023 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3389/fmed.2023.1276502 |
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| Förderinstitution / Projekttitel: |
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NLM365670731 |
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| 245 | 1 | 0 | |a Microperimetric evaluation and predictive factors of visual recovery after successful inverted internal limiting membrane-flap technique for macular hole in high myopic eyes |
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| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Copyright © 2023 Sborgia, Boscia, Niro, Landini, Pastore, Albano, Piepoli, Donghia, Dore, Viggiano, Buonamassa, Di Pardo, Molfetta, Eye Clinic Research Group, Coassin, Dell’Omo, Boscia, Alessio and Sborgia. | ||
| 520 | |a Introduction: Inverted Internal Limiting Membrane (ILM)-flap technique demonstrated its effectiveness, in terms of anatomical closure rate and visual acuity recovery for high myopic macular holes. We evaluated macular function after a successful inverted ILM-flap for macular holes in high myopic eyes (hMMH) using microperimetry to predict visual prognosis | ||
| 520 | |a Methods: A retrospective study on 23 eyes of 23 patients after surgical closure of hMMH, was performed. All patients underwent inverted ILM-flap and gas tamponade. Cataract surgery was performed in phakic eyes. Study outcomes including best-corrected visual acuity (BCVA), retinal sensitivity (RS) at central 12°, central retinal sensitivity (CRS) at central 4° and mean deviation (MD), and fixation behavior as bivariate contour ellipse area (BCEA, degrees2) measured by microperimetry, were evaluated over 6 months. A mixed-effects model was used to evaluate and compare the repeated measurements of outcomes between phakic and pseudophakic eyes. A regression model was performed to assess the relationship between BCVA at 6 months and independent variables | ||
| 520 | |a Results: Overall mean BCVA improved from 0.98 ± 0.21 logMAR at baseline to 0.47 ± 0.31 logMAR at the last follow-up (p < 0.001). Over 6 months, overall sensitivity measurements improved (RS, p = 0.001; CRS, p < 0.0001; MD, p = 0.03), and the BCEA decreased in dimension, although not significantly (p ≥ 0.05). The mixed model revealed a significantly better effect of inverted ILM-flap combined with cataract surgery on BCVA and CRS in phakic eyes than inverted ILM-flap alone in pseudophakic ones. The regression model revealed a relationship of 6-month BCVA with pre-operative BCVA (β = 0.60, p = 0.02) and RS (β = -0.03, p = 0.01) | ||
| 520 | |a Conclusion: The inverted ILM-flap technique significantly improved visual acuity and retinal sensitivity after the hMMH closure, particularly when combined with cataract extraction. Pre-operative visual acuity and retinal sensitivity at central 12° may predict post-surgical visual acuity | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a axial length | |
| 650 | 4 | |a fixation behavior | |
| 650 | 4 | |a high myopia | |
| 650 | 4 | |a inverted ILM-flap | |
| 650 | 4 | |a macular hole | |
| 650 | 4 | |a microperimetry | |
| 650 | 4 | |a retinal sensitivity | |
| 700 | 1 | |a Boscia, Giacomo |e verfasserin |4 aut | |
| 700 | 1 | |a Niro, Alfredo |e verfasserin |4 aut | |
| 700 | 1 | |a Landini, Luca |e verfasserin |4 aut | |
| 700 | 1 | |a Pastore, Valentina |e verfasserin |4 aut | |
| 700 | 1 | |a Albano, Valeria |e verfasserin |4 aut | |
| 700 | 1 | |a Piepoli, Marina |e verfasserin |4 aut | |
| 700 | 1 | |a Donghia, Rossella |e verfasserin |4 aut | |
| 700 | 1 | |a Dore, Stefano |e verfasserin |4 aut | |
| 700 | 1 | |a Viggiano, Pasquale |e verfasserin |4 aut | |
| 700 | 1 | |a Buonamassa, Rosa |e verfasserin |4 aut | |
| 700 | 1 | |a Di Pardo, Camilla |e verfasserin |4 aut | |
| 700 | 1 | |a Molfetta, Teresa |e verfasserin |4 aut | |
| 700 | 0 | |a Eye Clinic Research Group |e verfasserin |4 aut | |
| 700 | 1 | |a Coassin, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Dell'Omo, Roberto |e verfasserin |4 aut | |
| 700 | 1 | |a Boscia, Francesco |e verfasserin |4 aut | |
| 700 | 1 | |a Alessio, Giovanni |e verfasserin |4 aut | |
| 700 | 1 | |a Sborgia, Giancarlo |e verfasserin |4 aut | |
| 700 | 1 | |a Guglielmi, Antonella |e investigator |4 oth | |
| 700 | 1 | |a Scotti, Giacomo |e investigator |4 oth | |
| 700 | 1 | |a Gaudiomonte, Marida |e investigator |4 oth | |
| 700 | 1 | |a Semeraro, Roberto |e investigator |4 oth | |
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