Viral Load Dynamics in Plasma and Semen When Antiretroviral Therapy Is Initiated During Early HIV-1 Infection
© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com..
We assessed human immunodeficiency virus (HIV) load in plasma and semen during primary HIV infection using serial samples of semen and plasma during the first 24 weeks after diagnosis in untreated participants and those who started antiretroviral therapy (ART) immediately at diagnosis. In the absence of treatment, semen viral load was >1000 copies/mL in almost all specimens (83%) collected 2-10 weeks after the estimated date of HIV acquisition and remained >1000 copies/mL in 35% of untreated participants at the last observed time point. Thus, in the absence of ART, semen viral load remained at a level consistent with transmissibility throughout primary infection.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:229 |
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| Enthalten in: |
The Journal of infectious diseases - 229(2024), 4 vom: 12. Apr., Seite 1141-1146 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Gilada, Trupti [VerfasserIn] |
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| Links: |
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| Themen: |
Antiretroviral therapy (ART) |
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| Anmerkungen: |
Date Completed 15.04.2024 Date Revised 25.04.2024 published: Print Citation Status MEDLINE |
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| doi: |
10.1093/infdis/jiad520 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM365642746 |
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| 520 | |a © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com. | ||
| 520 | |a We assessed human immunodeficiency virus (HIV) load in plasma and semen during primary HIV infection using serial samples of semen and plasma during the first 24 weeks after diagnosis in untreated participants and those who started antiretroviral therapy (ART) immediately at diagnosis. In the absence of treatment, semen viral load was >1000 copies/mL in almost all specimens (83%) collected 2-10 weeks after the estimated date of HIV acquisition and remained >1000 copies/mL in 35% of untreated participants at the last observed time point. Thus, in the absence of ART, semen viral load remained at a level consistent with transmissibility throughout primary infection | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a HIV | |
| 650 | 4 | |a antiretroviral therapy (ART) | |
| 650 | 4 | |a blood | |
| 650 | 4 | |a plasma | |
| 650 | 4 | |a semen | |
| 650 | 4 | |a seminal plasma | |
| 650 | 4 | |a viral load | |
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| 700 | 1 | |a Ulrich, Angela K |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Yixin |e verfasserin |4 aut | |
| 700 | 1 | |a Lama, Javier R |e verfasserin |4 aut | |
| 700 | 1 | |a Alfaro, Ricardo |e verfasserin |4 aut | |
| 700 | 1 | |a Harb, Socorro |e verfasserin |4 aut | |
| 700 | 1 | |a Daza, Glenda |e verfasserin |4 aut | |
| 700 | 1 | |a Holte, Sarah |e verfasserin |4 aut | |
| 700 | 1 | |a Pasalar, Siavash |e verfasserin |4 aut | |
| 700 | 1 | |a Rios, Jessica |e verfasserin |4 aut | |
| 700 | 1 | |a Ganoza, Carmela |e verfasserin |4 aut | |
| 700 | 1 | |a Dasgupta, Sayan |e verfasserin |4 aut | |
| 700 | 1 | |a Coombs, Robert W |e verfasserin |4 aut | |
| 700 | 1 | |a Duerr, Ann |e verfasserin |4 aut | |
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