Pore-Engineered Hydrogen-Bonded Supramolecular Fluorosensor for Ultrasensitive Determination of Copper Ions
© 2023 Wiley-VCH GmbH..
The selective quantification of copper ions (Cu2+ ) in biosamples holds great importance for disease diagnosis, treatment, and prognosis since the Cu2+ level is closely associated with the physiological state of the human body. While it remains a long-term challenge due to the extremely low level of free Cu2+ and the potential interference by the complex matrices. Here, a pore-engineered hydrogen-bonded organic framework (HOF) fluorosensor is constructed enabling the ultrasensitive and highly selective detection of free Cu2+ . Attributing to atomically precise functionalization of active amino "arm" within the HOF pores and the periodic π-conjugated skeleton, this porous HOF fluorosensor affords high affinity toward Cu2+ through double copper-nitrogen (Cu─N) coordination interactions, resulting in specific fluorescence quenching of the HOF as compared with a series of substances ranging from other metal ions, metabolites, amino acids to proteins. Such superior fluorescence quenching effect endows the Cu2+ quantification by this new HOF sensor with a wide linearity of 50-20 000 nm, a low detection limit of 10 nm, and good recoveries (89.5%-115%) in human serum matrices, outperforming most of the reported approaches. This work highlights the practicability of hydrogen-bonded supramolecular engineering for designing facile and ultrasensitive biosensors for clinical free Cu2+ determination.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2023 |
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Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - year:2023 |
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Enthalten in: |
Small (Weinheim an der Bergstrasse, Germany) - (2023) vom: 10. Dez., Seite e2308716 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Chen, Haiting [VerfasserIn] |
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Links: |
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Themen: |
Bioanalysis |
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Anmerkungen: |
Date Revised 10.12.2023 published: Print-Electronic Citation Status Publisher |
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doi: |
10.1002/smll.202308716 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM365635782 |
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520 | |a The selective quantification of copper ions (Cu2+ ) in biosamples holds great importance for disease diagnosis, treatment, and prognosis since the Cu2+ level is closely associated with the physiological state of the human body. While it remains a long-term challenge due to the extremely low level of free Cu2+ and the potential interference by the complex matrices. Here, a pore-engineered hydrogen-bonded organic framework (HOF) fluorosensor is constructed enabling the ultrasensitive and highly selective detection of free Cu2+ . Attributing to atomically precise functionalization of active amino "arm" within the HOF pores and the periodic π-conjugated skeleton, this porous HOF fluorosensor affords high affinity toward Cu2+ through double copper-nitrogen (Cu─N) coordination interactions, resulting in specific fluorescence quenching of the HOF as compared with a series of substances ranging from other metal ions, metabolites, amino acids to proteins. Such superior fluorescence quenching effect endows the Cu2+ quantification by this new HOF sensor with a wide linearity of 50-20 000 nm, a low detection limit of 10 nm, and good recoveries (89.5%-115%) in human serum matrices, outperforming most of the reported approaches. This work highlights the practicability of hydrogen-bonded supramolecular engineering for designing facile and ultrasensitive biosensors for clinical free Cu2+ determination | ||
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700 | 1 | |a Huang, Haoquan |e verfasserin |4 aut | |
700 | 1 | |a Xu, Huiying |e verfasserin |4 aut | |
700 | 1 | |a Wu, Tong |e verfasserin |4 aut | |
700 | 1 | |a Xu, Yanbin |e verfasserin |4 aut | |
700 | 1 | |a Ma, Xiaomin |e verfasserin |4 aut | |
700 | 1 | |a Yi, Wei |e verfasserin |4 aut | |
700 | 1 | |a Chen, Guosheng |e verfasserin |4 aut | |
700 | 1 | |a Huang, Siming |e verfasserin |4 aut | |
700 | 1 | |a Ouyang, Gangfeng |e verfasserin |4 aut | |
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