Associations between actigraphy-measured sleep duration, continuity, and timing with mortality in the UK Biobank
Published by Oxford University Press on behalf of Sleep Research Society (SRS) 2023..
STUDY OBJECTIVES: To examine the associations between sleep duration, continuity, timing, and mortality using actigraphy among adults.
METHODS: Data were from a cohort of 88 282 adults (40-69 years) in UK Biobank that wore a wrist-worn triaxial accelerometer for 7 days. Actigraphy data were processed to generate estimates of sleep duration and other sleep characteristics including wake after sleep onset (WASO), number of 5-minute awakenings, and midpoint for sleep onset/wake-up and the least active 5 hours (L5). Data were linked to mortality outcomes with follow-up to October 31, 2021. We implemented Cox models (hazard ratio, confidence intervals [HR, 95% CI]) to quantify sleep associations with mortality. Models were adjusted for demographics, lifestyle factors, and medical conditions.
RESULTS: Over an average of 6.8 years 2973 deaths occurred (1700 cancer, 586 CVD deaths). Overall sleep duration was significantly associated with risk for all-cause (p < 0.01), cancer (p < 0.01), and CVD (p = 0.03) mortality. For example, when compared to sleep durations of 7.0 hrs/d, durations of 5 hrs/d were associated with a 29% higher risk for all-cause mortality (HR: 1.29 [1.09, 1.52]). WASO and number of awakenings were not associated with mortality. Individuals with L5 early or late midpoints (<2:30 or ≥ 3:30) had a ~20% higher risk for all-cause mortality, compared to those with intermediate L5 midpoints (3:00-3:29; p ≤ 0.01; e.g. HR ≥ 3:30: 1.19 [1.07, 1.32]).
CONCLUSIONS: Shorter sleep duration and both early and late sleep timing were associated with a higher mortality risk. These findings reinforce the importance of public health efforts to promote healthy sleep patterns in adults.
| Errataetall: | |
|---|---|
| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:47 |
|---|---|
| Enthalten in: |
Sleep - 47(2024), 3 vom: 11. März |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Saint-Maurice, Pedro F [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Completed 12.03.2024 Date Revised 13.03.2024 published: Print CommentIn: Sleep. 2024 Jan 10;:. - PMID 38204329 Citation Status MEDLINE |
|---|
| doi: |
10.1093/sleep/zsad312 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM365575097 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM365575097 | ||
| 003 | DE-627 | ||
| 005 | 20240313233904.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/sleep/zsad312 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1326.xml |
| 035 | |a (DE-627)NLM365575097 | ||
| 035 | |a (NLM)38066693 | ||
| 035 | |a (PII)zsad312 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Saint-Maurice, Pedro F |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Associations between actigraphy-measured sleep duration, continuity, and timing with mortality in the UK Biobank |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 12.03.2024 | ||
| 500 | |a Date Revised 13.03.2024 | ||
| 500 | |a published: Print | ||
| 500 | |a CommentIn: Sleep. 2024 Jan 10;:. - PMID 38204329 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Published by Oxford University Press on behalf of Sleep Research Society (SRS) 2023. | ||
| 520 | |a STUDY OBJECTIVES: To examine the associations between sleep duration, continuity, timing, and mortality using actigraphy among adults | ||
| 520 | |a METHODS: Data were from a cohort of 88 282 adults (40-69 years) in UK Biobank that wore a wrist-worn triaxial accelerometer for 7 days. Actigraphy data were processed to generate estimates of sleep duration and other sleep characteristics including wake after sleep onset (WASO), number of 5-minute awakenings, and midpoint for sleep onset/wake-up and the least active 5 hours (L5). Data were linked to mortality outcomes with follow-up to October 31, 2021. We implemented Cox models (hazard ratio, confidence intervals [HR, 95% CI]) to quantify sleep associations with mortality. Models were adjusted for demographics, lifestyle factors, and medical conditions | ||
| 520 | |a RESULTS: Over an average of 6.8 years 2973 deaths occurred (1700 cancer, 586 CVD deaths). Overall sleep duration was significantly associated with risk for all-cause (p < 0.01), cancer (p < 0.01), and CVD (p = 0.03) mortality. For example, when compared to sleep durations of 7.0 hrs/d, durations of 5 hrs/d were associated with a 29% higher risk for all-cause mortality (HR: 1.29 [1.09, 1.52]). WASO and number of awakenings were not associated with mortality. Individuals with L5 early or late midpoints (<2:30 or ≥ 3:30) had a ~20% higher risk for all-cause mortality, compared to those with intermediate L5 midpoints (3:00-3:29; p ≤ 0.01; e.g. HR ≥ 3:30: 1.19 [1.07, 1.32]) | ||
| 520 | |a CONCLUSIONS: Shorter sleep duration and both early and late sleep timing were associated with a higher mortality risk. These findings reinforce the importance of public health efforts to promote healthy sleep patterns in adults | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a UK Biobank | |
| 650 | 4 | |a accelerometry | |
| 650 | 4 | |a adults | |
| 650 | 4 | |a epidemiology | |
| 700 | 1 | |a Freeman, Joshua R |e verfasserin |4 aut | |
| 700 | 1 | |a Russ, Daniel |e verfasserin |4 aut | |
| 700 | 1 | |a Almeida, Jonas S |e verfasserin |4 aut | |
| 700 | 1 | |a Shams-White, Marissa M |e verfasserin |4 aut | |
| 700 | 1 | |a Patel, Shreya |e verfasserin |4 aut | |
| 700 | 1 | |a Wolff-Hughes, Dana L |e verfasserin |4 aut | |
| 700 | 1 | |a Watts, Eleanor L |e verfasserin |4 aut | |
| 700 | 1 | |a Loftfield, Erikka |e verfasserin |4 aut | |
| 700 | 1 | |a Hong, Hyokyoung G |e verfasserin |4 aut | |
| 700 | 1 | |a Moore, Steven C |e verfasserin |4 aut | |
| 700 | 1 | |a Matthews, Charles E |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Sleep |d 1986 |g 47(2024), 3 vom: 11. März |w (DE-627)NLM00225574X |x 1550-9109 |7 nnns |
| 773 | 1 | 8 | |g volume:47 |g year:2024 |g number:3 |g day:11 |g month:03 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1093/sleep/zsad312 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 47 |j 2024 |e 3 |b 11 |c 03 | ||