Cause-specific mortality and comorbid neurodevelopmental disorder in 167,515 patients with bipolar disorder : An entire population longitudinal study
Copyright © 2023. Published by Elsevier B.V..
OBJECTIVE: Studies addressing premature mortality in bipolar disorder (BD) patients are limited by small sample sizes. Herein, we used almost 99 % of the population of Taiwan to address this issue, and its association with comorbid neurodevelopmental disorders and severe BD.
METHODS: Between 2003 and 2017, we enrolled 167,515 individuals with BD and controls matched 1:4 for sex and birth year from the National Health Insurance Database linked to the Database of National Death Registry in Taiwan. Time-dependent Cox regression models were used to examine cause-specific mortality (all-cause, natural, and unnatural causes [accidents or suicide]).
RESULTS: With adjustments of sex, age, income, urbanization, and physical conditions, suicide was associated with the highest risk of mortality (reported as hazard ratio with 95 % confidence interval: 9.15; 8.53-9.81) among BD patients, followed by unnatural (4.94; 4.72-5.17), accidental (2.15; 1.99-2.32), and natural causes (1.02; 1.00-1.05). Comorbid attention-deficiency hyperactivity disorder did not contribute to the increased risk of cause-specific mortality; however, comorbid autism spectrum disorder (ASD) increased such risks, particularly for natural (3.00; 1.85-4.88) and accidental causes (7.47; 1.80-31.1). Cause-specific mortality revealed a linear trend with the frequency of psychiatric hospitalization (all, p for trend <0.001), and BD patients hospitalized twice or more each year had 34.63-fold increased risk of suicide mortality (26.03-46.07).
CONCLUSIONS: BD patients with a higher frequency of psychiatric hospitalization have the highest risk of suicide mortality, and comorbid ASD was associated with an increased risk of natural and accidental causes of mortality.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:347 |
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| Enthalten in: |
Journal of affective disorders - 347(2024) vom: 15. Feb., Seite 463-468 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cho, Wei-Min [VerfasserIn] |
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| Links: |
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| Themen: |
Attention-deficiency hyperactivity disorder |
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| Anmerkungen: |
Date Completed 08.01.2024 Date Revised 08.02.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jad.2023.12.007 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM365563064 |
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| 100 | 1 | |a Cho, Wei-Min |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Cause-specific mortality and comorbid neurodevelopmental disorder in 167,515 patients with bipolar disorder |b An entire population longitudinal study |
| 264 | 1 | |c 2024 | |
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| 500 | |a Date Revised 08.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023. Published by Elsevier B.V. | ||
| 520 | |a OBJECTIVE: Studies addressing premature mortality in bipolar disorder (BD) patients are limited by small sample sizes. Herein, we used almost 99 % of the population of Taiwan to address this issue, and its association with comorbid neurodevelopmental disorders and severe BD | ||
| 520 | |a METHODS: Between 2003 and 2017, we enrolled 167,515 individuals with BD and controls matched 1:4 for sex and birth year from the National Health Insurance Database linked to the Database of National Death Registry in Taiwan. Time-dependent Cox regression models were used to examine cause-specific mortality (all-cause, natural, and unnatural causes [accidents or suicide]) | ||
| 520 | |a RESULTS: With adjustments of sex, age, income, urbanization, and physical conditions, suicide was associated with the highest risk of mortality (reported as hazard ratio with 95 % confidence interval: 9.15; 8.53-9.81) among BD patients, followed by unnatural (4.94; 4.72-5.17), accidental (2.15; 1.99-2.32), and natural causes (1.02; 1.00-1.05). Comorbid attention-deficiency hyperactivity disorder did not contribute to the increased risk of cause-specific mortality; however, comorbid autism spectrum disorder (ASD) increased such risks, particularly for natural (3.00; 1.85-4.88) and accidental causes (7.47; 1.80-31.1). Cause-specific mortality revealed a linear trend with the frequency of psychiatric hospitalization (all, p for trend <0.001), and BD patients hospitalized twice or more each year had 34.63-fold increased risk of suicide mortality (26.03-46.07) | ||
| 520 | |a CONCLUSIONS: BD patients with a higher frequency of psychiatric hospitalization have the highest risk of suicide mortality, and comorbid ASD was associated with an increased risk of natural and accidental causes of mortality | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Attention-deficiency hyperactivity disorder | |
| 650 | 4 | |a Autism spectrum disorder | |
| 650 | 4 | |a Bipolar disorder | |
| 650 | 4 | |a Mortality | |
| 650 | 4 | |a Specific-cause mortality | |
| 650 | 4 | |a Suicide | |
| 700 | 1 | |a Hsu, Tien-Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Cheng, Chih-Ming |e verfasserin |4 aut | |
| 700 | 1 | |a Chang, Wen-Han |e verfasserin |4 aut | |
| 700 | 1 | |a Tsai, Shih-Jen |e verfasserin |4 aut | |
| 700 | 1 | |a Bai, Ya-Mei |e verfasserin |4 aut | |
| 700 | 1 | |a Su, Tung-Ping |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Tzeng-Ji |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Mu-Hong |e verfasserin |4 aut | |
| 700 | 1 | |a Liang, Chih-Sung |e verfasserin |4 aut | |
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