Multi-drug resistance Trichophyton indotineae in a stray dog
Copyright © 2023 Elsevier Ltd. All rights reserved..
A 2.5-year-old stray dog showed signs of hair loss, mild skin crusting, and redness on extremities and trunk. The etiologic agent was confirmed as Trichophyton indotineae by sequencing of ITS region. Using the Clinical and Laboratory Standards Institute (CLSI M38-A3) guideline, antifungal susceptibility testing showed multidrug resistance phenotype against terbinafine (16 μg/mL-1), itraconazole, and some other tested antifungals (minimum inhibitory concentration, MIC≥16 μg/mL-1). However, luliconazole was found to be active in- vitro (0.016 μg/mL-1). Upon further studies, sequencing of SQLE gene showed an amino acids substitution of Phe397Leu and Ala448Thr, which is potentially linked to terbinafine resistance in Trichophyton species.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:166 |
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| Enthalten in: |
Research in veterinary science - 166(2024) vom: 15. Jan., Seite 105105 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Oladzad, Vahid [VerfasserIn] |
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| Links: |
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| Themen: |
Antifungal Agents |
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| Anmerkungen: |
Date Completed 01.01.2024 Date Revised 01.01.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.rvsc.2023.105105 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a A 2.5-year-old stray dog showed signs of hair loss, mild skin crusting, and redness on extremities and trunk. The etiologic agent was confirmed as Trichophyton indotineae by sequencing of ITS region. Using the Clinical and Laboratory Standards Institute (CLSI M38-A3) guideline, antifungal susceptibility testing showed multidrug resistance phenotype against terbinafine (16 μg/mL-1), itraconazole, and some other tested antifungals (minimum inhibitory concentration, MIC≥16 μg/mL-1). However, luliconazole was found to be active in- vitro (0.016 μg/mL-1). Upon further studies, sequencing of SQLE gene showed an amino acids substitution of Phe397Leu and Ala448Thr, which is potentially linked to terbinafine resistance in Trichophyton species | ||
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| 650 | 4 | |a Canine dermatophytosis | |
| 650 | 4 | |a Stray dog, multidrug- resistance | |
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| 700 | 1 | |a Seyedmousavi, Seyedmojtaba |e verfasserin |4 aut | |
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