Information maximization-based clustering of histopathology images using deep learning
Copyright: © 2023 Rumman et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited..
Pancreatic cancer is one of the most adverse diseases and it is very difficult to treat because the cancer cells formed in the pancreas intertwine themselves with nearby blood vessels and connective tissue. Hence, the surgical procedure of treatment becomes complicated and it does not always lead to a cure. Histopathological diagnosis is the usual approach for cancer diagnosis. However, the pancreas remains so deep inside the body that experts sometimes struggle to detect cancer in it. Computer-aided diagnosis can come to the aid of pathologists in this scenario. It assists experts by supporting their diagnostic decisions. In this research, we carried out a deep learning-based approach to analyze histopathology images. We collected whole-slide images of KPC mice to implement this work. The pancreatic abnormalities observed in KPC mice develop similar histological features to human beings. We created random patches from whole-slide images. Then, a convolutional autoencoder framework was used to embed these patches into an integrated latent space. We applied 'information maximization', a deep learning clustering technique to cluster the identical patches in an unsupervised manner since our dataset does not have annotation. Moreover, Uniform manifold approximation and projection, a nonlinear dimension reduction technique was utilized to visualize the embedded patches in a 2-dimensional space. Finally, we calculated a few internal cluster validation metrics to determine the optimal cluster set. Our work concentrated on patch-based anomaly detection in the whole slide histopathology images of KPC mice.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:2 |
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| Enthalten in: |
PLOS digital health - 2(2023), 12 vom: 30. Dez., Seite e0000391 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rumman, Mahfujul Islam [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Revised 08.12.2023 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1371/journal.pdig.0000391 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM36555295X |
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| 520 | |a Copyright: © 2023 Rumman et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | ||
| 520 | |a Pancreatic cancer is one of the most adverse diseases and it is very difficult to treat because the cancer cells formed in the pancreas intertwine themselves with nearby blood vessels and connective tissue. Hence, the surgical procedure of treatment becomes complicated and it does not always lead to a cure. Histopathological diagnosis is the usual approach for cancer diagnosis. However, the pancreas remains so deep inside the body that experts sometimes struggle to detect cancer in it. Computer-aided diagnosis can come to the aid of pathologists in this scenario. It assists experts by supporting their diagnostic decisions. In this research, we carried out a deep learning-based approach to analyze histopathology images. We collected whole-slide images of KPC mice to implement this work. The pancreatic abnormalities observed in KPC mice develop similar histological features to human beings. We created random patches from whole-slide images. Then, a convolutional autoencoder framework was used to embed these patches into an integrated latent space. We applied 'information maximization', a deep learning clustering technique to cluster the identical patches in an unsupervised manner since our dataset does not have annotation. Moreover, Uniform manifold approximation and projection, a nonlinear dimension reduction technique was utilized to visualize the embedded patches in a 2-dimensional space. Finally, we calculated a few internal cluster validation metrics to determine the optimal cluster set. Our work concentrated on patch-based anomaly detection in the whole slide histopathology images of KPC mice | ||
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| 700 | 1 | |a Altaf-Ul-Amin, M D |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Ming |e verfasserin |4 aut | |
| 700 | 1 | |a Kanaya, Shigehiko |e verfasserin |4 aut | |
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