Dinityrosyl Iron Complexes with Thiol-Containing Ligands as a Functionally Active "Working Form" of Nitric Oxide System in Living Organisms : A Review
Experimental data were summarized to assume that dinitrosyl iron complexes (DNICs) with thiol-containing ligands are an endogenous "working form" of the nitric oxide (NO) system in living organisms. DNICs can function as donors of both neutral NO molecules, which are responsible for positive regulatory effects of the NO system on various physiological and biochemical processes in humans and animals, and nitrosonium cations (NO^(+)), which are responsible mostly for negative cytotoxic activity of the system. Special attention is paid to the finding that DNICs, especially in combination with dithiocarbamate derivatives, suppress SARS-CoV-2 infection in Syrian hamsters.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:57 |
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| Enthalten in: |
Molekuliarnaia biologiia - 57(2023), 6 vom: 08. Nov., Seite 925-937 |
| Sprache: |
Russisch |
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| Beteiligte Personen: |
Vanin, A F [VerfasserIn] |
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| Links: |
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| Themen: |
Dinitrosyl iron complexes |
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| Anmerkungen: |
Date Revised 08.12.2023 published: Print Citation Status In-Process |
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| doi: |
10.31857/S0026898423060204, EDN: QLHGFC |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM365538388 |
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| 520 | |a Experimental data were summarized to assume that dinitrosyl iron complexes (DNICs) with thiol-containing ligands are an endogenous "working form" of the nitric oxide (NO) system in living organisms. DNICs can function as donors of both neutral NO molecules, which are responsible for positive regulatory effects of the NO system on various physiological and biochemical processes in humans and animals, and nitrosonium cations (NO^(+)), which are responsible mostly for negative cytotoxic activity of the system. Special attention is paid to the finding that DNICs, especially in combination with dithiocarbamate derivatives, suppress SARS-CoV-2 infection in Syrian hamsters | ||
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