The link between impaired oxygen supply and cognitive decline in peripheral artery disease
Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved..
Although peripheral artery disease (PAD) primarily affects large arteries outside the brain, PAD is also associated with elevated cerebral vulnerabilities, including greater risks for brain injury (such as stroke), cognitive decline and dementia. In the present review, we aim to evaluate recent literature and extract information on potential mechanisms linking PAD and consequences on the brain. Furthermore, we suggest novel therapeutic avenues to mitigate cognitive decline and reduce risk of brain injury in patients with PAD. Various interventions, notably exercise, directly or indirectly improve systemic blood flow and oxygen supply and are effective strategies in patients with PAD or cognitive decline. Moreover, triggering protective cellular and systemic mechanisms by modulating inspired oxygen concentrations are emerging as potential novel treatment strategies. While several genetic and pharmacological approaches to modulate adaptations to hypoxia showed promising results in preclinical models of PAD, no clear benefits have yet been clinically demonstrated. We argue that genetic/pharmacological regulation of the involved adaptive systems remains challenging but that therapeutic variation of inspired oxygen levels (e.g., hypoxia conditioning) are promising future interventions to mitigate associated cognitive decline in patients with PAD.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2023 |
|---|---|
| Enthalten in: |
Progress in cardiovascular diseases - (2023) vom: 06. Dez. |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Burtscher, Johannes [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Cardiovascular disease |
|---|
| Anmerkungen: |
Date Revised 24.12.2023 published: Print-Electronic Citation Status Publisher |
|---|
| doi: |
10.1016/j.pcad.2023.12.002 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM365525030 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM365525030 | ||
| 003 | DE-627 | ||
| 005 | 20231227140945.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.pcad.2023.12.002 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1238.xml |
| 035 | |a (DE-627)NLM365525030 | ||
| 035 | |a (NLM)38061613 | ||
| 035 | |a (PII)S0033-0620(23)00124-X | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Burtscher, Johannes |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The link between impaired oxygen supply and cognitive decline in peripheral artery disease |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 24.12.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a Although peripheral artery disease (PAD) primarily affects large arteries outside the brain, PAD is also associated with elevated cerebral vulnerabilities, including greater risks for brain injury (such as stroke), cognitive decline and dementia. In the present review, we aim to evaluate recent literature and extract information on potential mechanisms linking PAD and consequences on the brain. Furthermore, we suggest novel therapeutic avenues to mitigate cognitive decline and reduce risk of brain injury in patients with PAD. Various interventions, notably exercise, directly or indirectly improve systemic blood flow and oxygen supply and are effective strategies in patients with PAD or cognitive decline. Moreover, triggering protective cellular and systemic mechanisms by modulating inspired oxygen concentrations are emerging as potential novel treatment strategies. While several genetic and pharmacological approaches to modulate adaptations to hypoxia showed promising results in preclinical models of PAD, no clear benefits have yet been clinically demonstrated. We argue that genetic/pharmacological regulation of the involved adaptive systems remains challenging but that therapeutic variation of inspired oxygen levels (e.g., hypoxia conditioning) are promising future interventions to mitigate associated cognitive decline in patients with PAD | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Cardiovascular disease | |
| 650 | 4 | |a Cognition | |
| 650 | 4 | |a Dementia | |
| 650 | 4 | |a Exercise | |
| 650 | 4 | |a Hypoxia | |
| 650 | 4 | |a Peripheral artery disease | |
| 700 | 1 | |a Millet, Grégoire P |e verfasserin |4 aut | |
| 700 | 1 | |a Fresa, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Lanzi, Stefano |e verfasserin |4 aut | |
| 700 | 1 | |a Mazzolai, Lucia |e verfasserin |4 aut | |
| 700 | 1 | |a Pellegrin, Maxime |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Progress in cardiovascular diseases |d 1958 |g (2023) vom: 06. Dez. |w (DE-627)NLM000009903 |x 1873-1740 |7 nnns |
| 773 | 1 | 8 | |g year:2023 |g day:06 |g month:12 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.pcad.2023.12.002 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |j 2023 |b 06 |c 12 | ||