Reproductive outcomes and reproductive health care utilization among male survivors of childhood cancer : A DCCSS-LATER study
© 2023 The Authors. Cancer published by Wiley Periodicals LLC on behalf of American Cancer Society..
BACKGROUND: Treatment-related gonadal dysfunction leading to fertility problems is a frequently encountered late effect in childhood cancer survivors (CCSs). This study evaluated reproductive outcomes and reproductive health care utilization among male CCSs compared with male siblings.
METHODS: A nationwide cohort study was conducted as part of the Dutch Childhood Cancer Survivor LATER study part 1, a questionnaire and linkage study. A questionnaire addressing reproductive outcomes and reproductive health care was completed by 1317 male CCSs and 407 male siblings. A total of 491 CCSs and 185 siblings had a previous or current desire for children and were included in this study.
RESULTS: Fewer CCSs had biological children compared with siblings (65% vs. 88%; p < .001). The type of conception by men who fathered a child was comparable between CCSs and siblings (spontaneous conception of 90% of both groups; p = .86). The percentage of men who had consulted a reproductive specialist because of not siring a pregnancy was higher in CCSs compared with siblings (34% vs. 12%; p < .001). Following consultation, fewer CCSs underwent assisted reproductive techniques (ART) compared with siblings (41% vs. 77%; p = .001). After ART, fewer CCSs fathered a child compared with siblings (49% vs. 94%; p = .001).
CONCLUSIONS: More male survivors consult a reproductive specialist, but fewer survivors undergo ART and father a child after ART compared with siblings. This insight is important for understanding potential problems faced by survivors regarding family planning and emphasizes the importance of collaboration between oncologists and reproductive specialists.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:130 |
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| Enthalten in: |
Cancer - 130(2024), 6 vom: 15. März, Seite 995-1004 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Claessens, Joyce J M [VerfasserIn] |
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| Links: |
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| Themen: |
Assisted reproductive techniques |
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| Anmerkungen: |
Date Completed 26.02.2024 Date Revised 11.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/cncr.35119 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM365461520 |
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| 100 | 1 | |a Claessens, Joyce J M |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Reproductive outcomes and reproductive health care utilization among male survivors of childhood cancer |b A DCCSS-LATER study |
| 264 | 1 | |c 2024 | |
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| 500 | |a Date Completed 26.02.2024 | ||
| 500 | |a Date Revised 11.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 The Authors. Cancer published by Wiley Periodicals LLC on behalf of American Cancer Society. | ||
| 520 | |a BACKGROUND: Treatment-related gonadal dysfunction leading to fertility problems is a frequently encountered late effect in childhood cancer survivors (CCSs). This study evaluated reproductive outcomes and reproductive health care utilization among male CCSs compared with male siblings | ||
| 520 | |a METHODS: A nationwide cohort study was conducted as part of the Dutch Childhood Cancer Survivor LATER study part 1, a questionnaire and linkage study. A questionnaire addressing reproductive outcomes and reproductive health care was completed by 1317 male CCSs and 407 male siblings. A total of 491 CCSs and 185 siblings had a previous or current desire for children and were included in this study | ||
| 520 | |a RESULTS: Fewer CCSs had biological children compared with siblings (65% vs. 88%; p < .001). The type of conception by men who fathered a child was comparable between CCSs and siblings (spontaneous conception of 90% of both groups; p = .86). The percentage of men who had consulted a reproductive specialist because of not siring a pregnancy was higher in CCSs compared with siblings (34% vs. 12%; p < .001). Following consultation, fewer CCSs underwent assisted reproductive techniques (ART) compared with siblings (41% vs. 77%; p = .001). After ART, fewer CCSs fathered a child compared with siblings (49% vs. 94%; p = .001) | ||
| 520 | |a CONCLUSIONS: More male survivors consult a reproductive specialist, but fewer survivors undergo ART and father a child after ART compared with siblings. This insight is important for understanding potential problems faced by survivors regarding family planning and emphasizes the importance of collaboration between oncologists and reproductive specialists | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a assisted reproductive techniques | |
| 650 | 4 | |a childhood cancer survivors | |
| 650 | 4 | |a infertility | |
| 650 | 4 | |a male | |
| 650 | 4 | |a reproductive health services | |
| 700 | 1 | |a Penson, Adriaan |e verfasserin |4 aut | |
| 700 | 1 | |a Bronkhorst, Ewald M |e verfasserin |4 aut | |
| 700 | 1 | |a Kremer, Leontien C M |e verfasserin |4 aut | |
| 700 | 1 | |a van Dulmen-den Broeder, Eline |e verfasserin |4 aut | |
| 700 | 1 | |a van der Heiden-van der Loo, Margriet |e verfasserin |4 aut | |
| 700 | 1 | |a Tissing, Wim J E |e verfasserin |4 aut | |
| 700 | 1 | |a van der Pal, Helena J H |e verfasserin |4 aut | |
| 700 | 1 | |a Blijlevens, Nicole M A |e verfasserin |4 aut | |
| 700 | 1 | |a van den Heuvel-Eibrink, Marry M |e verfasserin |4 aut | |
| 700 | 1 | |a Versluys, A Birgitta |e verfasserin |4 aut | |
| 700 | 1 | |a Bresters, Dorine |e verfasserin |4 aut | |
| 700 | 1 | |a Ronckers, Cécile M |e verfasserin |4 aut | |
| 700 | 1 | |a Walraven, Iris |e verfasserin |4 aut | |
| 700 | 1 | |a Beerendonk, Catharina C M |e verfasserin |4 aut | |
| 700 | 1 | |a Loonen, Jacqueline J |e verfasserin |4 aut | |
| 700 | 0 | |a Dutch LATER study group |e verfasserin |4 aut | |
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