Lysine methylation signaling in skeletal muscle biology : from myogenesis to clinical insights

© 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society..

Lysine methylation signaling is well studied for its key roles in the regulation of transcription states through modifications on histone proteins. While histone lysine methylation has been extensively studied, recent discoveries of lysine methylation on thousands of non-histone proteins has broadened our appreciation for this small chemical modification in the regulation of protein function. In this review, we highlight the significance of histone and non-histone lysine methylation signaling in skeletal muscle biology, spanning development, maintenance, regeneration, and disease progression. Furthermore, we discuss potential future implications for its roles in skeletal muscle biology as well as clinical applications for the treatment of skeletal muscle-related diseases.

Medienart:

E-Artikel

Erscheinungsjahr:

2023

Erschienen:

2023

Enthalten in:

Zur Gesamtaufnahme - volume:480

Enthalten in:

The Biochemical journal - 480(2023), 23 vom: 13. Dez., Seite 1969-1986

Sprache:

Englisch

Beteiligte Personen:

Cordeiro-Spinetti, Eric [VerfasserIn]
Rothbart, Scott B [VerfasserIn]

Links:

Volltext

Themen:

Epigenetics
Histones
Journal Article
K3Z4F929H6
Lysine
Lysine methylation
Myogenesis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Anmerkungen:

Date Completed 07.12.2023

Date Revised 28.12.2023

published: Print

Citation Status MEDLINE

doi:

10.1042/BCJ20230223

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM36545513X