Associations between physical activity and all-cause and cardiovascular mortality in adults with type 2 diabetes mellitus : A prospective cohort study from NHANES 2007-2018
Copyright © 2023 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved..
AIMS: To investigate the dose-response association between physical activity and all-cause and cardiovascular mortality in adults with type 2 diabetes mellitus and the effects of replacing sedentary behavior with physical activity.
METHODS: 4808 adults with type 2 diabetes mellitus were included in NHANES 2007-2018. Cox proportional hazards models were used to calculate hazard ratios and 95% confidence intervals. Isotemporal substitution analyses were further to determine the possible benefit of replacing sedentary time.
RESULTS: During a median follow-up of 6.58 years, 902 deaths occurred, including 290 deaths from cardiovascular disease. Compared with the inactive group, the low-active and high-active groups were associated with declined risks of all-cause mortality [HRs (95% CIs) 0.64 (0.50, 0.83); 0.60 (0.50, 0.73), respectively] and cardiovascular mortality [0.50 (0.29, 0.88); 0.54 (0.39, 0.76)), respectively]. Dose-response analysis showed a significant U-shaped curve between physical activity and all-cause and cardiovascular mortality. Replacing 30 min/day of sedentary time with physical activity was substantially linked to a reduced risk of 8-32% mortality.
CONCLUSION: A high level of PA of 40.52 and 31.66 MET-h/week was respectively related to the lowest risk of all-cause and cardiovascular mortality. Replacing sedentary time with physical activity could benefit the type 2 diabetes mellitus population.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:18 |
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| Enthalten in: |
Primary care diabetes - 18(2024), 1 vom: 01. Feb., Seite 44-51 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lu, Jie [VerfasserIn] |
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| Links: |
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| Themen: |
Cardiovascular |
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| Anmerkungen: |
Date Completed 14.02.2024 Date Revised 05.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.pcd.2023.11.010 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM365436356 |
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| 245 | 1 | 0 | |a Associations between physical activity and all-cause and cardiovascular mortality in adults with type 2 diabetes mellitus |b A prospective cohort study from NHANES 2007-2018 |
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| 500 | |a Date Revised 05.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved. | ||
| 520 | |a AIMS: To investigate the dose-response association between physical activity and all-cause and cardiovascular mortality in adults with type 2 diabetes mellitus and the effects of replacing sedentary behavior with physical activity | ||
| 520 | |a METHODS: 4808 adults with type 2 diabetes mellitus were included in NHANES 2007-2018. Cox proportional hazards models were used to calculate hazard ratios and 95% confidence intervals. Isotemporal substitution analyses were further to determine the possible benefit of replacing sedentary time | ||
| 520 | |a RESULTS: During a median follow-up of 6.58 years, 902 deaths occurred, including 290 deaths from cardiovascular disease. Compared with the inactive group, the low-active and high-active groups were associated with declined risks of all-cause mortality [HRs (95% CIs) 0.64 (0.50, 0.83); 0.60 (0.50, 0.73), respectively] and cardiovascular mortality [0.50 (0.29, 0.88); 0.54 (0.39, 0.76)), respectively]. Dose-response analysis showed a significant U-shaped curve between physical activity and all-cause and cardiovascular mortality. Replacing 30 min/day of sedentary time with physical activity was substantially linked to a reduced risk of 8-32% mortality | ||
| 520 | |a CONCLUSION: A high level of PA of 40.52 and 31.66 MET-h/week was respectively related to the lowest risk of all-cause and cardiovascular mortality. Replacing sedentary time with physical activity could benefit the type 2 diabetes mellitus population | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Cardiovascular | |
| 650 | 4 | |a Dose-response relationship | |
| 650 | 4 | |a Isotemporal substitution model | |
| 650 | 4 | |a Mortality | |
| 650 | 4 | |a Physical activity | |
| 650 | 4 | |a Type 2 diabetes mellitus | |
| 700 | 1 | |a Cao, Xiting |e verfasserin |4 aut | |
| 700 | 1 | |a Chang, Xinyu |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Guowei |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Hao |e verfasserin |4 aut | |
| 700 | 1 | |a Gao, Shuaijie |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Zhenwei |e verfasserin |4 aut | |
| 700 | 1 | |a Jia, Xiaocan |e verfasserin |4 aut | |
| 700 | 1 | |a Shi, Xuezhong |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Yongli |e verfasserin |4 aut | |
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