Biofunctional Inorganic Layered Double Hydroxide Nanohybrid Enhances Immunotherapeutic Effect on Atopic Dermatitis Treatment
© 2023 Wiley‐VCH GmbH..
Atopic dermatitis (AD) is a widespread, recurrent, and chronic inflammatory skin condition that imposes a major burden on patients. Conventional treatments, such as corticosteroids, are associated with various side effects, underscoring the need for innovative therapeutic approaches. In this study, the possibility of using indole-3-acetic acid-loaded layered double hydroxides (IAA-LDHs) is evaluated as a novel treatment for AD. IAA is an auxin-class plant hormone with antioxidant and anti-inflammatory effects. Following the synthesis of IAA-LDH nanohybrids, their ability to induce M2-like macrophage polarization in macrophages obtained from mouse bone marrow is assessed. The antioxidant activity of IAA-LDH is quantified by assessing the decrease in intracellular reactive oxygen species levels. The anti-inflammatory and anti-atopic characteristics of IAA-LDH are evaluated in a mouse model of AD by examining the cutaneous tissues, immunological organs, and cells. The findings suggest that IAA-LDH has great therapeutic potential as a candidate for AD treatment based on its in vitro and in vivo modulation of AD immunology, enhancement of macrophage polarization, and antioxidant activity. This inorganic drug delivery technology represents a promising new avenue for the development of safe and effective AD treatments.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:20 |
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| Enthalten in: |
Small (Weinheim an der Bergstrasse, Germany) - 20(2024), 17 vom: 19. Apr., Seite e2304862 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Byun, Min Ji [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 25.04.2024 Date Revised 25.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/smll.202304862 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM365418811 |
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| 520 | |a © 2023 Wiley‐VCH GmbH. | ||
| 520 | |a Atopic dermatitis (AD) is a widespread, recurrent, and chronic inflammatory skin condition that imposes a major burden on patients. Conventional treatments, such as corticosteroids, are associated with various side effects, underscoring the need for innovative therapeutic approaches. In this study, the possibility of using indole-3-acetic acid-loaded layered double hydroxides (IAA-LDHs) is evaluated as a novel treatment for AD. IAA is an auxin-class plant hormone with antioxidant and anti-inflammatory effects. Following the synthesis of IAA-LDH nanohybrids, their ability to induce M2-like macrophage polarization in macrophages obtained from mouse bone marrow is assessed. The antioxidant activity of IAA-LDH is quantified by assessing the decrease in intracellular reactive oxygen species levels. The anti-inflammatory and anti-atopic characteristics of IAA-LDH are evaluated in a mouse model of AD by examining the cutaneous tissues, immunological organs, and cells. The findings suggest that IAA-LDH has great therapeutic potential as a candidate for AD treatment based on its in vitro and in vivo modulation of AD immunology, enhancement of macrophage polarization, and antioxidant activity. This inorganic drug delivery technology represents a promising new avenue for the development of safe and effective AD treatments | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Seo, Hee Seung |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Joonghak |e verfasserin |4 aut | |
| 700 | 1 | |a Ban, Kitae |e verfasserin |4 aut | |
| 700 | 1 | |a Oh, Serim |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Yun Young |e verfasserin |4 aut | |
| 700 | 1 | |a Lim, Jaesung |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Na Kyeong |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Chi-Pin James |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Minjeong |e verfasserin |4 aut | |
| 700 | 1 | |a Han, Jun-Hyeok |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Juwon |e verfasserin |4 aut | |
| 700 | 1 | |a Paik, Taejong |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Hee Ho |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Tae-Eun |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Wooram |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Se-Na |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Dae-Hwan |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Chun Gwon |e verfasserin |4 aut | |
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