A seromolecular study to determine the prevalence of cytomegalovirus in pregnant women referred to health centers in the north of Iran
Copyright © 2023 The Authors. Published by Tehran University of Medical Sciences..
Background and Objectives: Because of the controversial aspects of the CMV virus during pregnancy, it should be considered a serious health threat, especially in developing countries. The present seromolecular study aimed to determine cytomegalovirus prevalence in pregnant women referred to health centers in the north of Iran.
Materials and Methods: One hundred and twenty-five pregnant women who were referred to health centers in Mazandaran province for regular health checks were randomly selected from Jan 2022 to Oct 2022. To detect the presence of the CMV genome and specific IgM and IgG antibodies against cytomegalovirus, the conventional PCR and ELISA tests were applied respectively.
Results: All 125 pregnant women that attended the study were from Mazandaran province with a mean age of 30 years ranging from 20 to 42 years. The result showed that 2 (1.6%), 92 (73.6%), and 2 (1.6%) of the cases were positive for IgM, IgG, and IgM/IgG, respectively. The PCR test results indicated that the CMV DNA was present in 10 (8%) pregnant women. Our study shows that all PCR-positive cases were negative for the IgM test. Of the 10 PCR-positive samples 3 were positive and 1 was suspicious for the IgG test.
Conclusion: Our study revealed that there is an urgent need for vaccination or other strategies to prevent and treat congenital CMV infection. Reducing the burden of congenital CMV infection requires global awareness. Further studies are recommended to obtain accurate estimates of the risk of congenital CMV infection.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
Iranian journal of microbiology - 15(2023), 4 vom: 11. Aug., Seite 594-600 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Saravi, Negin Mesgar [VerfasserIn] |
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| Links: |
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| Themen: |
Cytomegalovirus |
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| Anmerkungen: |
Date Revised 05.12.2023 published: Print Citation Status PubMed-not-MEDLINE |
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| doi: |
10.18502/ijm.v15i4.13514 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM365366811 |
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| 245 | 1 | 2 | |a A seromolecular study to determine the prevalence of cytomegalovirus in pregnant women referred to health centers in the north of Iran |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Revised 05.12.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Copyright © 2023 The Authors. Published by Tehran University of Medical Sciences. | ||
| 520 | |a Background and Objectives: Because of the controversial aspects of the CMV virus during pregnancy, it should be considered a serious health threat, especially in developing countries. The present seromolecular study aimed to determine cytomegalovirus prevalence in pregnant women referred to health centers in the north of Iran | ||
| 520 | |a Materials and Methods: One hundred and twenty-five pregnant women who were referred to health centers in Mazandaran province for regular health checks were randomly selected from Jan 2022 to Oct 2022. To detect the presence of the CMV genome and specific IgM and IgG antibodies against cytomegalovirus, the conventional PCR and ELISA tests were applied respectively | ||
| 520 | |a Results: All 125 pregnant women that attended the study were from Mazandaran province with a mean age of 30 years ranging from 20 to 42 years. The result showed that 2 (1.6%), 92 (73.6%), and 2 (1.6%) of the cases were positive for IgM, IgG, and IgM/IgG, respectively. The PCR test results indicated that the CMV DNA was present in 10 (8%) pregnant women. Our study shows that all PCR-positive cases were negative for the IgM test. Of the 10 PCR-positive samples 3 were positive and 1 was suspicious for the IgG test | ||
| 520 | |a Conclusion: Our study revealed that there is an urgent need for vaccination or other strategies to prevent and treat congenital CMV infection. Reducing the burden of congenital CMV infection requires global awareness. Further studies are recommended to obtain accurate estimates of the risk of congenital CMV infection | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Cytomegalovirus | |
| 650 | 4 | |a Iran | |
| 650 | 4 | |a Pregnant women | |
| 650 | 4 | |a Seromolecular | |
| 700 | 1 | |a Aghajani, Faegheh |e verfasserin |4 aut | |
| 700 | 1 | |a Najafi, Ahmad |e verfasserin |4 aut | |
| 700 | 1 | |a Khajavi, Rezvan |e verfasserin |4 aut | |
| 700 | 1 | |a Rahmani, Zahra |e verfasserin |4 aut | |
| 700 | 1 | |a Jalali, Hossein |e verfasserin |4 aut | |
| 700 | 1 | |a Mousavi, Tahoora |e verfasserin |4 aut | |
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