Tumor infiltrating lymphocytes (TILs) are a prognosis biomarker in Colombian patients with triple negative breast cancer
© 2023. The Author(s)..
Triple negative breast cancer (TNBC) is highly immunogenic and high levels of tumor infiltrating lymphocytes (TILs) have been associated with a better prognosis and higher probability to achieve pathological complete response. Here, we explore the potential role of stromal TILs level and composition as a prognostic and predictive biomarker in TNBC. 195 Tumor biospecimens from patients diagnosed with TNBC were included. Stromal TILs (sTILs), positive CD4/CD8 cells were evaluated. Differences in clinic-pathological characteristics according to immune infiltration were assessed. The predictive and prognostic value of immune infiltration was analyzed by multivariate models. Higher immune infiltration was observed in patients with favorable clinical-pathological features. Survival analysis showed that longer overall survival times were observed in patients with a higher infiltration of sTILs (p = 0.00043), CD4 + (p = 0.0074) and CD8 + (p = 0.008). In the multivariate analysis, low levels of sTILs were found to be associated with a higher mortality hazard (HR: 1.59, 95% CI 1.01-2.48). CD4 and CD8 immune infiltration were associated with higher odds for pathological complete response (OR: 1.20, 95% CI 1.00-1.46, OR: 1.28, 1.02-1.65, respectively). Our results suggest that immune infiltration could be used as a prognostic marker for overall survival in TNBC patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
Scientific reports - 13(2023), 1 vom: 03. Dez., Seite 21324 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Huertas-Caro, Carlos A [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 05.12.2023 Date Revised 22.12.2023 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1038/s41598-023-48300-4 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Triple negative breast cancer (TNBC) is highly immunogenic and high levels of tumor infiltrating lymphocytes (TILs) have been associated with a better prognosis and higher probability to achieve pathological complete response. Here, we explore the potential role of stromal TILs level and composition as a prognostic and predictive biomarker in TNBC. 195 Tumor biospecimens from patients diagnosed with TNBC were included. Stromal TILs (sTILs), positive CD4/CD8 cells were evaluated. Differences in clinic-pathological characteristics according to immune infiltration were assessed. The predictive and prognostic value of immune infiltration was analyzed by multivariate models. Higher immune infiltration was observed in patients with favorable clinical-pathological features. Survival analysis showed that longer overall survival times were observed in patients with a higher infiltration of sTILs (p = 0.00043), CD4 + (p = 0.0074) and CD8 + (p = 0.008). In the multivariate analysis, low levels of sTILs were found to be associated with a higher mortality hazard (HR: 1.59, 95% CI 1.01-2.48). CD4 and CD8 immune infiltration were associated with higher odds for pathological complete response (OR: 1.20, 95% CI 1.00-1.46, OR: 1.28, 1.02-1.65, respectively). Our results suggest that immune infiltration could be used as a prognostic marker for overall survival in TNBC patients | ||
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| 700 | 1 | |a Ballen, Diego Felipe |e verfasserin |4 aut | |
| 700 | 1 | |a Nuñez, Marcela |e verfasserin |4 aut | |
| 700 | 1 | |a Mejía, Juan Carlos |e verfasserin |4 aut | |
| 700 | 1 | |a Sua-Villegas, Luz Fernanda |e verfasserin |4 aut | |
| 700 | 1 | |a Cock-Rada, Alicia |e verfasserin |4 aut | |
| 700 | 1 | |a Zabaleta, Jovanny |e verfasserin |4 aut | |
| 700 | 1 | |a Fejerman, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Sanabria-Salas, María Carolina |e verfasserin |4 aut | |
| 700 | 1 | |a Serrano-Gomez, Silvia J |e verfasserin |4 aut | |
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