Potential regulatory role of PGC-1α within the skeletal muscle during metabolic adaptations in response to high-fat diet feeding in animal models
© 2023. The Author(s)..
High-fat diet (HFD) feeding in rodents has become an essential tool to critically analyze and study the pathological effects of obesity, including mitochondrial dysfunction and insulin resistance. Peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) regulates cellular energy metabolism to influence insulin sensitivity, beyond its active role in stimulating mitochondrial biogenesis to facilitate skeletal muscle adaptations in response to HFD feeding. Here, some of the major electronic databases like PubMed, Embase, and Web of Science were accessed to update and critically discuss information on the potential role of PGC-1α during metabolic adaptations within the skeletal muscle in response to HFD feeding in rodents. In fact, available evidence suggests that partial exposure to HFD feeding (potentially during the early stages of disease development) is associated with impaired metabolic adaptations within the skeletal muscle, including mitochondrial dysfunction and reduced insulin sensitivity. In terms of implicated molecular mechanisms, these negative effects are partially associated with reduced activity of PGC-1α, together with the phosphorylation of protein kinase B and altered expression of genes involving nuclear respiratory factor 1 and mitochondrial transcription factor A within the skeletal muscle. Notably, metabolic abnormalities observed with chronic exposure to HFD (likely during the late stages of disease development) may potentially occur independently of PGC-1α regulation within the muscle of rodents. Summarized evidence suggests the causal relationship between PGC-1α regulation and effective modulations of mitochondrial biogenesis and metabolic flexibility during the different stages of disease development. It further indicates that prominent interventions like caloric restriction and physical exercise may affect PGC-1α regulation during effective modulation of metabolic processes.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:476 |
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| Enthalten in: |
Pflugers Archiv : European journal of physiology - 476(2024), 3 vom: 08. März, Seite 283-293 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mthembu, Sinenhlanhla X H [VerfasserIn] |
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| Links: |
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| Themen: |
High-fat diet |
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| Anmerkungen: |
Date Completed 08.02.2024 Date Revised 27.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00424-023-02890-0 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a High-fat diet (HFD) feeding in rodents has become an essential tool to critically analyze and study the pathological effects of obesity, including mitochondrial dysfunction and insulin resistance. Peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) regulates cellular energy metabolism to influence insulin sensitivity, beyond its active role in stimulating mitochondrial biogenesis to facilitate skeletal muscle adaptations in response to HFD feeding. Here, some of the major electronic databases like PubMed, Embase, and Web of Science were accessed to update and critically discuss information on the potential role of PGC-1α during metabolic adaptations within the skeletal muscle in response to HFD feeding in rodents. In fact, available evidence suggests that partial exposure to HFD feeding (potentially during the early stages of disease development) is associated with impaired metabolic adaptations within the skeletal muscle, including mitochondrial dysfunction and reduced insulin sensitivity. In terms of implicated molecular mechanisms, these negative effects are partially associated with reduced activity of PGC-1α, together with the phosphorylation of protein kinase B and altered expression of genes involving nuclear respiratory factor 1 and mitochondrial transcription factor A within the skeletal muscle. Notably, metabolic abnormalities observed with chronic exposure to HFD (likely during the late stages of disease development) may potentially occur independently of PGC-1α regulation within the muscle of rodents. Summarized evidence suggests the causal relationship between PGC-1α regulation and effective modulations of mitochondrial biogenesis and metabolic flexibility during the different stages of disease development. It further indicates that prominent interventions like caloric restriction and physical exercise may affect PGC-1α regulation during effective modulation of metabolic processes | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a High-fat diet | |
| 650 | 4 | |a Insulin resistance | |
| 650 | 4 | |a Mitochondrial function | |
| 650 | 4 | |a Obesity | |
| 650 | 4 | |a PGC-1α | |
| 650 | 4 | |a Skeletal muscle | |
| 650 | 7 | |a Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha |2 NLM | |
| 700 | 1 | |a Mazibuko-Mbeje, Sithandiwe E |e verfasserin |4 aut | |
| 700 | 1 | |a Ziqubu, Khanyisani |e verfasserin |4 aut | |
| 700 | 1 | |a Muvhulawa, Ndivhuwo |e verfasserin |4 aut | |
| 700 | 1 | |a Marcheggiani, Fabio |e verfasserin |4 aut | |
| 700 | 1 | |a Cirilli, Ilenia |e verfasserin |4 aut | |
| 700 | 1 | |a Nkambule, Bongani B |e verfasserin |4 aut | |
| 700 | 1 | |a Muller, Christo J F |e verfasserin |4 aut | |
| 700 | 1 | |a Basson, Albertus K |e verfasserin |4 aut | |
| 700 | 1 | |a Tiano, Luca |e verfasserin |4 aut | |
| 700 | 1 | |a Dludla, Phiwayinkosi V |e verfasserin |4 aut | |
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