An advanced strategy for quality evaluation of Xinyi Biyan Pill by UPLC-DAD fingerprinting combined with multi-components UPLC-MS/MS analysis
Copyright © 2023 Elsevier B.V. All rights reserved..
Xinyi Biyan Pill (XBP) is a classical Chinese patent medicine and widely used to treat acute and chronic or allergic rhinitis in clinical practice. This study aimed to establish and validate a comprehensive strategy combining ultra-performance liquid chromatography with diode array detector (UPLC-DAD) fingerprinting and multi-component quantification for quality evaluation of XBP. In the fingerprint analysis, 32 peaks were selected as common peaks and used to evaluate the similarity of 12 batches of XBP. In addition, 141 compounds of XBP were identified or preliminarily characterized in both positive and negative ion modes by coupling with an advanced hybrid linear ion trap (LTQ)-Orbitrap mass spectrometer. Moreover, a rapid quantitative method based on UPLC tandem mass spectrometry (UPLC-MS/MS) has been optimized and validated for simultaneous determination of 10 chemical markers within 15 min, and applied to analyzing 12 batches of XBP. The proposed comprehensive strategy combining UPLC-DAD fingerprinting and multi-component UPLC-MS/MS quantification exhibited satisfactory results with high efficiency, accuracy and reliability, which can be used as a reference for overall quality consistency evaluation of Chinese herbal formulations.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:239 |
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| Enthalten in: |
Journal of pharmaceutical and biomedical analysis - 239(2024) vom: 15. Jan., Seite 115858 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lu, Yang [VerfasserIn] |
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| Links: |
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| Themen: |
Chemical characterization |
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| Anmerkungen: |
Date Completed 05.01.2024 Date Revised 05.01.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jpba.2023.115858 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 Elsevier B.V. All rights reserved. | ||
| 520 | |a Xinyi Biyan Pill (XBP) is a classical Chinese patent medicine and widely used to treat acute and chronic or allergic rhinitis in clinical practice. This study aimed to establish and validate a comprehensive strategy combining ultra-performance liquid chromatography with diode array detector (UPLC-DAD) fingerprinting and multi-component quantification for quality evaluation of XBP. In the fingerprint analysis, 32 peaks were selected as common peaks and used to evaluate the similarity of 12 batches of XBP. In addition, 141 compounds of XBP were identified or preliminarily characterized in both positive and negative ion modes by coupling with an advanced hybrid linear ion trap (LTQ)-Orbitrap mass spectrometer. Moreover, a rapid quantitative method based on UPLC tandem mass spectrometry (UPLC-MS/MS) has been optimized and validated for simultaneous determination of 10 chemical markers within 15 min, and applied to analyzing 12 batches of XBP. The proposed comprehensive strategy combining UPLC-DAD fingerprinting and multi-component UPLC-MS/MS quantification exhibited satisfactory results with high efficiency, accuracy and reliability, which can be used as a reference for overall quality consistency evaluation of Chinese herbal formulations | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Chemical characterization | |
| 650 | 4 | |a Chemical fingerprint | |
| 650 | 4 | |a Multi-components UPLC-MS/MS quantification | |
| 650 | 4 | |a Quality evaluation | |
| 650 | 4 | |a Xinyi Biyan Pill | |
| 650 | 7 | |a Drugs, Chinese Herbal |2 NLM | |
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| 700 | 1 | |a Wang, Qin |e verfasserin |4 aut | |
| 700 | 1 | |a Lei, Ting |e verfasserin |4 aut | |
| 700 | 1 | |a Ning, Na |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Xinyang |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Xu |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Shengpeng |e verfasserin |4 aut | |
| 700 | 1 | |a Wan, Li |e verfasserin |4 aut | |
| 700 | 1 | |a Cao, Jiliang |e verfasserin |4 aut | |
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