Characteristics and predictors of chronic kidney disease in children with myelomeningocele : a nationwide cohort study
© 2023. The Author(s), under exclusive licence to International Pediatric Nephrology Association..
BACKGROUND: Myelomeningocele (MMC) is highly prevalent in developing countries, and MMC-related neurogenic bladder is an important cause of childhood chronic kidney disease (CKD). This nationwide study aimed to evaluate demographic and clinical features of pediatric patients with MMC in Turkey and risk factors associated with CKD stage 5.
METHODS: Data from children aged 0-19 years old, living with MMC in 2022, were retrospectively collected from 27 pediatric nephrology centers. Patients > 1 year of age without pre-existing kidney abnormalities were divided into five groups according to eGFR; CKD stages 1-5. Patients on dialysis, kidney transplant recipients, and those with eGFR < 15 ml/min/1.73 m2 but not on kidney replacement therapy at time of study constituted the CKD stage 5 group.
RESULTS: A total of 911 (57.8% female) patients were enrolled, most of whom were expectantly managed. Stages 1-4 CKD were found in 34.3%, 4.2%, 4.1%, and 2.4%, respectively. CKD stage 5 was observed in 5.3% of patients at median 13 years old (range 2-18 years). Current age, age at first abnormal DMSA scan, moderate-to-severe trabeculated bladder on US and/or VCUG, and VUR history were independent risk factors for development of CKD stage 5 (OR 0.752; 95%; CI 0.658-0.859; p < 0.001; OR 1.187; 95% CI 1.031-1.367; p = 0.017; OR 10.031; 95% CI 2.210-45.544; p = 0.003; OR 2.722; 95% CI 1.215-6.102; p = 0.015, respectively). Only eight CKD stage 5 patients underwent surgery related to a hostile bladder between 1 and 15 years old.
CONCLUSION: MMC-related CKD is common in childhood in Turkey. A proactive approach to neurogenic bladder management and early protective surgery in selected cases where conservative treatment has failed should be implemented to prevent progressive kidney failure in the pediatric MMC population in our country.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:39 |
---|---|
Enthalten in: |
Pediatric nephrology (Berlin, Germany) - 39(2024), 5 vom: 01. März, Seite 1509-1519 |
Sprache: |
Englisch |
---|
Links: |
---|
Themen: |
Child |
---|
Anmerkungen: |
Date Completed 18.03.2024 Date Revised 18.03.2024 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1007/s00467-023-06212-5 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM365318655 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM365318655 | ||
003 | DE-627 | ||
005 | 20240318233848.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1007/s00467-023-06212-5 |2 doi | |
028 | 5 | 2 | |a pubmed24n1334.xml |
035 | |a (DE-627)NLM365318655 | ||
035 | |a (NLM)38040872 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Doğan, Çağla Serpil |e verfasserin |4 aut | |
245 | 1 | 0 | |a Characteristics and predictors of chronic kidney disease in children with myelomeningocele |b a nationwide cohort study |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 18.03.2024 | ||
500 | |a Date Revised 18.03.2024 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a © 2023. The Author(s), under exclusive licence to International Pediatric Nephrology Association. | ||
520 | |a BACKGROUND: Myelomeningocele (MMC) is highly prevalent in developing countries, and MMC-related neurogenic bladder is an important cause of childhood chronic kidney disease (CKD). This nationwide study aimed to evaluate demographic and clinical features of pediatric patients with MMC in Turkey and risk factors associated with CKD stage 5 | ||
520 | |a METHODS: Data from children aged 0-19 years old, living with MMC in 2022, were retrospectively collected from 27 pediatric nephrology centers. Patients > 1 year of age without pre-existing kidney abnormalities were divided into five groups according to eGFR; CKD stages 1-5. Patients on dialysis, kidney transplant recipients, and those with eGFR < 15 ml/min/1.73 m2 but not on kidney replacement therapy at time of study constituted the CKD stage 5 group | ||
520 | |a RESULTS: A total of 911 (57.8% female) patients were enrolled, most of whom were expectantly managed. Stages 1-4 CKD were found in 34.3%, 4.2%, 4.1%, and 2.4%, respectively. CKD stage 5 was observed in 5.3% of patients at median 13 years old (range 2-18 years). Current age, age at first abnormal DMSA scan, moderate-to-severe trabeculated bladder on US and/or VCUG, and VUR history were independent risk factors for development of CKD stage 5 (OR 0.752; 95%; CI 0.658-0.859; p < 0.001; OR 1.187; 95% CI 1.031-1.367; p = 0.017; OR 10.031; 95% CI 2.210-45.544; p = 0.003; OR 2.722; 95% CI 1.215-6.102; p = 0.015, respectively). Only eight CKD stage 5 patients underwent surgery related to a hostile bladder between 1 and 15 years old | ||
520 | |a CONCLUSION: MMC-related CKD is common in childhood in Turkey. A proactive approach to neurogenic bladder management and early protective surgery in selected cases where conservative treatment has failed should be implemented to prevent progressive kidney failure in the pediatric MMC population in our country | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Child | |
650 | 4 | |a Chronic kidney disease | |
650 | 4 | |a Myelomeningocele | |
650 | 4 | |a Neurogenic bladder | |
650 | 4 | |a Predictors | |
700 | 1 | |a Taner, Sevgin |e verfasserin |4 aut | |
700 | 1 | |a Tiryaki, Betül Durucu |e verfasserin |4 aut | |
700 | 1 | |a Alaygut, Demet |e verfasserin |4 aut | |
700 | 1 | |a Özkayın, Neşe |e verfasserin |4 aut | |
700 | 1 | |a Kara, Aslıhan |e verfasserin |4 aut | |
700 | 1 | |a Gençler, Aylin |e verfasserin |4 aut | |
700 | 1 | |a Pınarbaşı, Ayşe Seda |e verfasserin |4 aut | |
700 | 1 | |a Nalçacıoğlu, Hülya |e verfasserin |4 aut | |
700 | 1 | |a Yüksel, Selçuk |e verfasserin |4 aut | |
700 | 1 | |a Akacı, Okan |e verfasserin |4 aut | |
700 | 1 | |a Yılmaz, Esra Karabağ |e verfasserin |4 aut | |
700 | 1 | |a Yavuz, Sevgi |e verfasserin |4 aut | |
700 | 1 | |a Doğan, Kenan |e verfasserin |4 aut | |
700 | 1 | |a Gülşan, Rumeysa Yasemin Çiçek |e verfasserin |4 aut | |
700 | 1 | |a Aksoy, Gülşah Kaya |e verfasserin |4 aut | |
700 | 1 | |a Çiçek, Neslihan |e verfasserin |4 aut | |
700 | 1 | |a Aksu, Bağdagül |e verfasserin |4 aut | |
700 | 1 | |a Küçük, Nuran |e verfasserin |4 aut | |
700 | 1 | |a Altugan, Fatma Şemsa |e verfasserin |4 aut | |
700 | 1 | |a Selçuk, Şenay Zırhlı |e verfasserin |4 aut | |
700 | 1 | |a Baştuğ, Funda |e verfasserin |4 aut | |
700 | 1 | |a Erfidan, Gökçen |e verfasserin |4 aut | |
700 | 1 | |a Atmış, Bahriye |e verfasserin |4 aut | |
700 | 1 | |a Gökçeoğlu, Arife Uslu |e verfasserin |4 aut | |
700 | 1 | |a Önder, Esra Nagehan Akyol |e verfasserin |4 aut | |
700 | 1 | |a Elmacı, Ahmet Mithat |e verfasserin |4 aut | |
700 | 1 | |a Cengiz, Nurcan |e verfasserin |4 aut | |
700 | 1 | |a Gülleroğlu, Kaan |e verfasserin |4 aut | |
700 | 1 | |a Yılmaz, Ebru Bekiroğlu |e verfasserin |4 aut | |
700 | 1 | |a Tayfur, Aslı Çelebi |e verfasserin |4 aut | |
700 | 1 | |a Yılmaz, Gülsün Gülay |e verfasserin |4 aut | |
700 | 1 | |a Yel, Sİbel |e verfasserin |4 aut | |
700 | 1 | |a Pehlivanoğlu, Cemile |e verfasserin |4 aut | |
700 | 1 | |a Akgün, Cihangir |e verfasserin |4 aut | |
700 | 1 | |a Kara, Mehtap Akbalık |e verfasserin |4 aut | |
700 | 1 | |a Kılıç, Beltinge Demircioğlu |e verfasserin |4 aut | |
700 | 1 | |a Şimşek, Özgür Özdemir |e verfasserin |4 aut | |
700 | 1 | |a Yucal, Melike |e verfasserin |4 aut | |
700 | 1 | |a Ağar, Buket Esen |e verfasserin |4 aut | |
700 | 1 | |a Gürgöze, Metin Kaya |e verfasserin |4 aut | |
700 | 1 | |a Yağmur, İsmail |e verfasserin |4 aut | |
700 | 1 | |a Madsar, Ömer |e verfasserin |4 aut | |
700 | 1 | |a Karalı, Demet Tekcan |e verfasserin |4 aut | |
700 | 1 | |a Girişgen, İlknur |e verfasserin |4 aut | |
700 | 1 | |a Bodur, Ece Demirci |e verfasserin |4 aut | |
700 | 1 | |a Çomak, Elif |e verfasserin |4 aut | |
700 | 1 | |a Gökçe, İbrahim |e verfasserin |4 aut | |
700 | 1 | |a Kaya, Mehtap |e verfasserin |4 aut | |
700 | 1 | |a Tabel, Yılmaz |e verfasserin |4 aut | |
700 | 1 | |a Günay, Neslihan |e verfasserin |4 aut | |
700 | 1 | |a Gülmez, Rüveyda |e verfasserin |4 aut | |
700 | 1 | |a Çalışkan, Salim |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Pediatric nephrology (Berlin, Germany) |d 1995 |g 39(2024), 5 vom: 01. März, Seite 1509-1519 |w (DE-627)NLM012612111 |x 1432-198X |7 nnns |
773 | 1 | 8 | |g volume:39 |g year:2024 |g number:5 |g day:01 |g month:03 |g pages:1509-1519 |
856 | 4 | 0 | |u http://dx.doi.org/10.1007/s00467-023-06212-5 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 39 |j 2024 |e 5 |b 01 |c 03 |h 1509-1519 |