Investigation of circadian rhythm gene Per3 in diabetic neuropathy
PURPOSE: Diabetic neuropathy (DN) is a serious complication of diabetes that affects peripheral and autonomic nerves, and it has been linked to irregularities in circadian rhythm. Several studies have demonstrated that disruptions in circadian rhythm and changes in expression of rhythm genes may play a role in the development and progression of diabetes, including the development of DN.
METHODS: In this study, the association between the VNTR polymorphism of the PER3 gene and diabetic neuropathy was investigated. The study included 84 patients with diabetes, 220 patients with diabetic neuropathy, and 218 healthy individuals as the control group.
RESULTS: Upon analyzing the data from the study, it was found that there was no significant difference in the PER3 VNTR polymorphism between the diabetic neuropathy patients, diabetes and control groups. However, there was a significant difference observed between the control group and the diabetes group, particularly in terms of the 5/5 genotype and 5 alleles. Moreover, a significant difference was observed between the patient group and the control group (p < 0.05).
CONCLUSIONS: In conclusion, first in the world, the relationship between PER3 gene VNTR polymorphism and diabetic neuropathy and diabetes, was investigated. Our results showed that PER3 may be associated with diabetes but not with diabetic neuropathy.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2023 |
|---|---|
| Enthalten in: |
Nucleosides, nucleotides & nucleic acids - (2023) vom: 01. Dez., Seite 1-11 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Rüstemoğlu, Hüsniye [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Revised 01.12.2023 published: Print-Electronic Citation Status Publisher |
|---|
| doi: |
10.1080/15257770.2023.2286996 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM365290726 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM365290726 | ||
| 003 | DE-627 | ||
| 005 | 20231226101344.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1080/15257770.2023.2286996 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1217.xml |
| 035 | |a (DE-627)NLM365290726 | ||
| 035 | |a (NLM)38037954 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Rüstemoğlu, Hüsniye |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Investigation of circadian rhythm gene Per3 in diabetic neuropathy |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 01.12.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a PURPOSE: Diabetic neuropathy (DN) is a serious complication of diabetes that affects peripheral and autonomic nerves, and it has been linked to irregularities in circadian rhythm. Several studies have demonstrated that disruptions in circadian rhythm and changes in expression of rhythm genes may play a role in the development and progression of diabetes, including the development of DN | ||
| 520 | |a METHODS: In this study, the association between the VNTR polymorphism of the PER3 gene and diabetic neuropathy was investigated. The study included 84 patients with diabetes, 220 patients with diabetic neuropathy, and 218 healthy individuals as the control group | ||
| 520 | |a RESULTS: Upon analyzing the data from the study, it was found that there was no significant difference in the PER3 VNTR polymorphism between the diabetic neuropathy patients, diabetes and control groups. However, there was a significant difference observed between the control group and the diabetes group, particularly in terms of the 5/5 genotype and 5 alleles. Moreover, a significant difference was observed between the patient group and the control group (p < 0.05) | ||
| 520 | |a CONCLUSIONS: In conclusion, first in the world, the relationship between PER3 gene VNTR polymorphism and diabetic neuropathy and diabetes, was investigated. Our results showed that PER3 may be associated with diabetes but not with diabetic neuropathy | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Diabetes | |
| 650 | 4 | |a PER3 | |
| 650 | 4 | |a diabetic neuropathy | |
| 650 | 4 | |a vNTR | |
| 700 | 1 | |a Aci, Recai |e verfasserin |4 aut | |
| 700 | 1 | |a Uzun, Süheyla |e verfasserin |4 aut | |
| 700 | 1 | |a Yiğit, Serbülent |e verfasserin |4 aut | |
| 700 | 1 | |a Rüstemoğlu, Aydın |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nucleosides, nucleotides & nucleic acids |d 2000 |g (2023) vom: 01. Dez., Seite 1-11 |w (DE-627)NLM10699560X |x 1532-2335 |7 nnns |
| 773 | 1 | 8 | |g year:2023 |g day:01 |g month:12 |g pages:1-11 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1080/15257770.2023.2286996 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |j 2023 |b 01 |c 12 |h 1-11 | ||