All-in-one fabrication of a ratiometric electrochemical aptasensor with tetrahedral DNA nanostructure for fumonisin B1 detection
Here, we develop an all-in-one strategy for efficient assembly of an electrochemical aptasensor. A multifunctional structure based on a tetrahedral DNA nanostructure (TDN) was synthesized via a one-step annealing process, providing DNA fixation, target recognition, signal amplification and space regulation. Based on the integration of this multifunctional structure, the sensing interface was assembled in one step. A ratiometric aptasensor was constructed by anchoring methylene blue (MB) to the TDN and ferrocene (Fc) on the cDNA. Using the ratio of the currents obtained from Fc and MB as a measure, the developed aptasensor shows excellent analytical performance for fumonisin B1 detection. This strategy is universal and could simplify the fabrication of aptasensors.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:60 |
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| Enthalten in: |
Chemical communications (Cambridge, England) - 60(2023), 1 vom: 19. Dez., Seite 110-113 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Dong, Na [VerfasserIn] |
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| Links: |
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| Themen: |
3ZZM97XZ32 |
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| Anmerkungen: |
Date Completed 20.12.2023 Date Revised 20.12.2023 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1039/d3cc04991d |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM365288314 |
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| 500 | |a Date Revised 20.12.2023 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Here, we develop an all-in-one strategy for efficient assembly of an electrochemical aptasensor. A multifunctional structure based on a tetrahedral DNA nanostructure (TDN) was synthesized via a one-step annealing process, providing DNA fixation, target recognition, signal amplification and space regulation. Based on the integration of this multifunctional structure, the sensing interface was assembled in one step. A ratiometric aptasensor was constructed by anchoring methylene blue (MB) to the TDN and ferrocene (Fc) on the cDNA. Using the ratio of the currents obtained from Fc and MB as a measure, the developed aptasensor shows excellent analytical performance for fumonisin B1 detection. This strategy is universal and could simplify the fabrication of aptasensors | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a fumonisin B1 |2 NLM | |
| 650 | 7 | |a 3ZZM97XZ32 |2 NLM | |
| 650 | 7 | |a Aptamers, Nucleotide |2 NLM | |
| 650 | 7 | |a Gold |2 NLM | |
| 650 | 7 | |a 7440-57-5 |2 NLM | |
| 650 | 7 | |a DNA |2 NLM | |
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| 650 | 7 | |a ferrocene |2 NLM | |
| 650 | 7 | |a U96PKG90JQ |2 NLM | |
| 650 | 7 | |a Methylene Blue |2 NLM | |
| 650 | 7 | |a T42P99266K |2 NLM | |
| 700 | 1 | |a Liu, Shuda |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Yuye |e verfasserin |4 aut | |
| 700 | 1 | |a Meng, Shuyun |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Yifan |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Xia |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Dong |e verfasserin |4 aut | |
| 700 | 1 | |a You, Tianyan |e verfasserin |4 aut | |
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