Remodeling of the Tumor Microenvironment by Radiotherapy through the cGAS-STING Pathway in Esophageal Squamous Cell Carcinoma
It has been reported that tumor cell-intrinsic cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING) pathway is essential for radiotherapy(RT)-induced activation of anti-tumor immune responses. However, its role in the RT- induced remodeling of the tumor microenvironment(TME)in esophageal squamous cell carcinoma(ESCC), is largely unknown. In this study, we found that the tumor cell-intrinsic cGAS-STING pathway is a critical component for RT-induced activation of immune cells in the TME through the induction of type Ⅰ interferon and C-X-C motif chemokine ligand 10 in tumor cells in ESCC. However, at the same time, the tumor cell-intrinsic cGAS-STING pathway is also involved in RT-triggered infiltration and polarization of immunosuppressive CD163+ tumor-associated macrophages (TAM) through the induction of interleukin 34 (IL-34) in tumor cells in ESCC. Our findings suggest that targeting IL-34 to impede the infiltration and polarization of CD163+ TAM could potentially enhance the efficacy of RT-induced immune cell activation in ESCC TME.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:50 |
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| Enthalten in: |
Gan to kagaku ryoho. Cancer & chemotherapy - 50(2023), 10 vom: 30. Okt., Seite 1099-1101 |
| Sprache: |
Japanisch |
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| Beteiligte Personen: |
Nakajima, Shotaro [VerfasserIn] |
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| Themen: |
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| Anmerkungen: |
Date Completed 04.12.2023 Date Revised 04.12.2023 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM365269646 |
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| 245 | 1 | 0 | |a Remodeling of the Tumor Microenvironment by Radiotherapy through the cGAS-STING Pathway in Esophageal Squamous Cell Carcinoma |
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| 520 | |a It has been reported that tumor cell-intrinsic cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING) pathway is essential for radiotherapy(RT)-induced activation of anti-tumor immune responses. However, its role in the RT- induced remodeling of the tumor microenvironment(TME)in esophageal squamous cell carcinoma(ESCC), is largely unknown. In this study, we found that the tumor cell-intrinsic cGAS-STING pathway is a critical component for RT-induced activation of immune cells in the TME through the induction of type Ⅰ interferon and C-X-C motif chemokine ligand 10 in tumor cells in ESCC. However, at the same time, the tumor cell-intrinsic cGAS-STING pathway is also involved in RT-triggered infiltration and polarization of immunosuppressive CD163+ tumor-associated macrophages (TAM) through the induction of interleukin 34 (IL-34) in tumor cells in ESCC. Our findings suggest that targeting IL-34 to impede the infiltration and polarization of CD163+ TAM could potentially enhance the efficacy of RT-induced immune cell activation in ESCC TME | ||
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Mimura, Kosaku |e verfasserin |4 aut | |
| 700 | 1 | |a Kaneta, Akinao |e verfasserin |4 aut | |
| 700 | 1 | |a Katagata, Masanori |e verfasserin |4 aut | |
| 700 | 1 | |a Okayama, Hirokazu |e verfasserin |4 aut | |
| 700 | 1 | |a Saito, Motonobu |e verfasserin |4 aut | |
| 700 | 1 | |a Saze, Zenichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Hanayama, Hiroyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Tada, Takeshi |e verfasserin |4 aut | |
| 700 | 1 | |a Momma, Tomoyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Kono, Koji |e verfasserin |4 aut | |
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