Anti-Gene IGF-I Vaccines in Cancer Gene Therapy : A Review of a Case of Glioblastoma
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
OBJECTIVE: Vaccines for the deadliest brain tumor - glioblastoma (GBM) - are generally based on targeting growth factors or their receptors, often using antibodies. The vaccines described in the review were prepared to suppress the principal cancer growth factor - IGF-I, using anti-gene approaches either of antisense (AS) or of triple helix (TH) type. Our objective was to increase the median survival of patients treated with AS and TH cell vaccines.
METHODOLOGY: The cells were transfected in vitro by both constructed IGF-I AS and IGF-I TH expression episomal vectors; part of these cells was co-cultured with plant phytochemicals, modulating IGF-I expression. Both AS and TH approaches completely suppressed IGF-I expression and induced MHC-1 / B7 immunogenicity related to the IGF-I receptor signal.
RESULTS: This immunogenicity proved to be stronger in IGF-I TH than in IGF-I AS-prepared cell vaccines, especially in TH / phytochemical cells. The AS and TH vaccines generated an important TCD8+ and TCD8+CD11b- immune response in treated GBM patients and increased the median survival of patients up to 17-18 months, particularly using TH vaccines; in some cases, 2- and 3-year survival was reported. These clinical results were compared with those obtained in therapies targeting other growth factors.
CONCLUSION: The anti-gene IGF-I vaccines continue to be applied in current GBM personalized medicine. Technical improvements in the preparation of AS and TH vaccines to increase MHC-1 and B7 immunogenicity have, in parallel, allowed to increase in the median survival of patients.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:31 |
---|---|
Enthalten in: |
Current medicinal chemistry - 31(2024), 15 vom: 23., Seite 1983-2002 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Trojan, Annabelle [VerfasserIn] |
---|
Links: |
---|
Themen: |
67763-96-6 |
---|
Anmerkungen: |
Date Completed 23.02.2024 Date Revised 23.02.2024 published: Print Citation Status MEDLINE |
---|
doi: |
10.2174/0109298673237968231106095141 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM365229156 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM365229156 | ||
003 | DE-627 | ||
005 | 20240229143906.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.2174/0109298673237968231106095141 |2 doi | |
028 | 5 | 2 | |a pubmed24n1303.xml |
035 | |a (DE-627)NLM365229156 | ||
035 | |a (NLM)38031775 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Trojan, Annabelle |e verfasserin |4 aut | |
245 | 1 | 0 | |a Anti-Gene IGF-I Vaccines in Cancer Gene Therapy |b A Review of a Case of Glioblastoma |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 23.02.2024 | ||
500 | |a Date Revised 23.02.2024 | ||
500 | |a published: Print | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
520 | |a OBJECTIVE: Vaccines for the deadliest brain tumor - glioblastoma (GBM) - are generally based on targeting growth factors or their receptors, often using antibodies. The vaccines described in the review were prepared to suppress the principal cancer growth factor - IGF-I, using anti-gene approaches either of antisense (AS) or of triple helix (TH) type. Our objective was to increase the median survival of patients treated with AS and TH cell vaccines | ||
520 | |a METHODOLOGY: The cells were transfected in vitro by both constructed IGF-I AS and IGF-I TH expression episomal vectors; part of these cells was co-cultured with plant phytochemicals, modulating IGF-I expression. Both AS and TH approaches completely suppressed IGF-I expression and induced MHC-1 / B7 immunogenicity related to the IGF-I receptor signal | ||
520 | |a RESULTS: This immunogenicity proved to be stronger in IGF-I TH than in IGF-I AS-prepared cell vaccines, especially in TH / phytochemical cells. The AS and TH vaccines generated an important TCD8+ and TCD8+CD11b- immune response in treated GBM patients and increased the median survival of patients up to 17-18 months, particularly using TH vaccines; in some cases, 2- and 3-year survival was reported. These clinical results were compared with those obtained in therapies targeting other growth factors | ||
520 | |a CONCLUSION: The anti-gene IGF-I vaccines continue to be applied in current GBM personalized medicine. Technical improvements in the preparation of AS and TH vaccines to increase MHC-1 and B7 immunogenicity have, in parallel, allowed to increase in the median survival of patients | ||
650 | 4 | |a Review | |
650 | 4 | |a Case Reports | |
650 | 4 | |a Journal Article | |
650 | 4 | |a Cancer gene therapy | |
650 | 4 | |a IGF-I | |
650 | 4 | |a anti-gene technology | |
650 | 4 | |a glioblastoma | |
650 | 4 | |a immuno-gene vaccine | |
650 | 4 | |a signal transduction. | |
650 | 7 | |a Insulin-Like Growth Factor I |2 NLM | |
650 | 7 | |a 67763-96-6 |2 NLM | |
650 | 7 | |a Vaccines |2 NLM | |
650 | 7 | |a Cancer Vaccines |2 NLM | |
700 | 1 | |a Lone, Yu-Chun |e verfasserin |4 aut | |
700 | 1 | |a Briceno, Ignacio |e verfasserin |4 aut | |
700 | 1 | |a Trojan, Jerzy |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Current medicinal chemistry |d 1997 |g 31(2024), 15 vom: 23., Seite 1983-2002 |w (DE-627)NLM093833857 |x 1875-533X |7 nnns |
773 | 1 | 8 | |g volume:31 |g year:2024 |g number:15 |g day:23 |g pages:1983-2002 |
856 | 4 | 0 | |u http://dx.doi.org/10.2174/0109298673237968231106095141 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 31 |j 2024 |e 15 |b 23 |h 1983-2002 |