Comparison of Renal Damage Following Renal Artery Embolization with Three Different Embolic Mixtures in Swine
© 2023 Japanese Society of Interventional Radiology..
Purpose: Renal artery embolization is a minimally invasive and effective procedure for renal ablation, a complete necrosis of the renal parenchyma. This study aims to compare the extent of renal damage in swine following renal artery embolization with ethanol and N-butyl-2-cyanoacrylate, commonly used as embolic materials in renal ablation.
Material and Methods: Three different embolic mixtures were prepared for renal artery embolization in swine: 33% ethanol-Lipiodol mixture (ethanol:Lipiodol = 1:2; Group A), 67% ethanol-Lipiodol mixture (ethanol:Lipiodol = 2:1; Group B), and 10% N-butyl-2-cyanoacrylate-Lipiodol mixture (N-butyl-2-cyanoacrylate:Lipiodol = 1:9; Group C). Three swine were assigned to each group and underwent embolization of the unilateral renal artery. Renal arteriography was performed before, immediately after, and two days after renal artery embolization. After two days, the kidneys were removed to determine the macroscopic necrosis rate and for histologic examination. Dark tissue regions were considered necrotic.
Results: The macroscopic necrosis rate of the kidneys was 50.3%±7.4%, 100%±0%, and 100%±0% in Groups A, B, and C, respectively. The necrosis rates were higher in Groups B and C than in Group A. Histologically, the renal tubules were damaged in the necrotic areas. In addition, the glomeruli were damaged in Groups A and B but were preserved in Group C.
Conclusions: Sixty-seven percent ethanol-Lipiodol mixture and 10% N-butyl-2-cyanoacrylate-Lipiodol mixture are effective embolic materials in renal artery embolization for renal ablation in swine. Also, ethanol caused partial glomerular necrosis, whereas N-butyl-2-cyanoacrylate preserved the glomeruli. Therefore, ethanol should be used for renal ablation.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:8 |
|---|---|
| Enthalten in: |
Interventional radiology (Higashimatsuyama-shi (Japan) - 8(2023), 3 vom: 01. Nov., Seite 154-160 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Tanaka, Ryota [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Revised 01.12.2023 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.22575/interventionalradiology.2021-0031 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM365116009 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM365116009 | ||
| 003 | DE-627 | ||
| 005 | 20231226101003.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.22575/interventionalradiology.2021-0031 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1216.xml |
| 035 | |a (DE-627)NLM365116009 | ||
| 035 | |a (NLM)38020457 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Tanaka, Ryota |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Comparison of Renal Damage Following Renal Artery Embolization with Three Different Embolic Mixtures in Swine |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 01.12.2023 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2023 Japanese Society of Interventional Radiology. | ||
| 520 | |a Purpose: Renal artery embolization is a minimally invasive and effective procedure for renal ablation, a complete necrosis of the renal parenchyma. This study aims to compare the extent of renal damage in swine following renal artery embolization with ethanol and N-butyl-2-cyanoacrylate, commonly used as embolic materials in renal ablation | ||
| 520 | |a Material and Methods: Three different embolic mixtures were prepared for renal artery embolization in swine: 33% ethanol-Lipiodol mixture (ethanol:Lipiodol = 1:2; Group A), 67% ethanol-Lipiodol mixture (ethanol:Lipiodol = 2:1; Group B), and 10% N-butyl-2-cyanoacrylate-Lipiodol mixture (N-butyl-2-cyanoacrylate:Lipiodol = 1:9; Group C). Three swine were assigned to each group and underwent embolization of the unilateral renal artery. Renal arteriography was performed before, immediately after, and two days after renal artery embolization. After two days, the kidneys were removed to determine the macroscopic necrosis rate and for histologic examination. Dark tissue regions were considered necrotic | ||
| 520 | |a Results: The macroscopic necrosis rate of the kidneys was 50.3%±7.4%, 100%±0%, and 100%±0% in Groups A, B, and C, respectively. The necrosis rates were higher in Groups B and C than in Group A. Histologically, the renal tubules were damaged in the necrotic areas. In addition, the glomeruli were damaged in Groups A and B but were preserved in Group C | ||
| 520 | |a Conclusions: Sixty-seven percent ethanol-Lipiodol mixture and 10% N-butyl-2-cyanoacrylate-Lipiodol mixture are effective embolic materials in renal artery embolization for renal ablation in swine. Also, ethanol caused partial glomerular necrosis, whereas N-butyl-2-cyanoacrylate preserved the glomeruli. Therefore, ethanol should be used for renal ablation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a NBCA | |
| 650 | 4 | |a RAE | |
| 650 | 4 | |a ethanol | |
| 650 | 4 | |a renal ablation | |
| 700 | 1 | |a Sonomura, Tetsuo |e verfasserin |4 aut | |
| 700 | 1 | |a Koike, Masataka |e verfasserin |4 aut | |
| 700 | 1 | |a Sato, Hirotatsu |e verfasserin |4 aut | |
| 700 | 1 | |a Shimono, Ryuki |e verfasserin |4 aut | |
| 700 | 1 | |a Kumamoto, Akihiko |e verfasserin |4 aut | |
| 700 | 1 | |a Fukuda, Kodai |e verfasserin |4 aut | |
| 700 | 1 | |a Higashino, Nobuyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Ikoma, Akira |e verfasserin |4 aut | |
| 700 | 1 | |a Murata, Shin-Ichi |e verfasserin |4 aut | |
| 700 | 1 | |a Minamiguchi, Hiroki |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Interventional radiology (Higashimatsuyama-shi (Japan) |d 2020 |g 8(2023), 3 vom: 01. Nov., Seite 154-160 |w (DE-627)NLM344295982 |x 2432-0935 |7 nnns |
| 773 | 1 | 8 | |g volume:8 |g year:2023 |g number:3 |g day:01 |g month:11 |g pages:154-160 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.22575/interventionalradiology.2021-0031 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 8 |j 2023 |e 3 |b 01 |c 11 |h 154-160 | ||