Dietary fat, telomere length and cognitive function : unravelling the complex relations

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PURPOSE OF REVIEW: The review aims to explore the recent evidence on the associations between different dietary fat intake and cognitive function, and to understand the role of telomere length in this relationship.

RECENT FINDINGS: Clinical and preclinical studies included in this review suggest that dietary fat intake is associated with cognitive function and telomere length. High intake of saturated fats and trans fats, commonly found in ultra-processed foods, appears to have negative effects on cognitive function and telomere length, while other dietary fats, such as omega-3 polyunsaturated fatty acids and monounsaturated fatty acids are associated with improved cognitive performance and reduced telomere attrition. Controversial results related to omega-6 polyunsaturated fatty acids intake and its impact on cognitive function were found. Dietary fats may affect telomere length and cognition through oxidative stress, inflammation, and insulin resistance.

SUMMARY: The current review illustrated the relationship between dietary fat and cognitive function by focusing on the role of telomere length as a potential intermediator. More future studies are required, however, in order to develop targeted interventions aimed at preserving cognitive well-being throughout life.

Medienart:

E-Artikel

Erscheinungsjahr:

2024

2023

Erschienen:

2024

Enthalten in:

Zur Gesamtaufnahme - volume:35

Enthalten in:

Current opinion in lipidology - 35(2023), 1 vom: 01. Feb., Seite 33-40

Sprache:

Englisch

Beteiligte Personen:

Mostafa, Hamza [VerfasserIn]
Gutierrez-Tordera, Laia [VerfasserIn]
Mateu-Fabregat, Javier [VerfasserIn]
Papandreou, Christopher [VerfasserIn]
Bulló, Mònica [VerfasserIn]

Links:

Volltext

Themen:

Dietary Fats
Fatty Acids
Fatty Acids, Monounsaturated
Journal Article
Review

Anmerkungen:

Date Completed 20.12.2023

Date Revised 20.12.2023

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1097/MOL.0000000000000900

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM365100196