The association between trypsin-like protease activity in the oral cavity and kidney function in Japanese workers
© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd..
AIM: To evaluate the association between trypsin-like protease (TLP) activity in the oral cavity as an indicator of periodontal health status and kidney function in Japanese workers.
MATERIALS AND METHODS: This cross-sectional study included 1117 Japanese workers (mean age = 43.8 years). Tongue-swab TLP activity was quantified as a* value (the redness intensity of the matrix disc of the TLP activity assessment kit; a larger value indicates more intense enzymatic activity in the samples and poorer periodontal health status). Kidney function was assessed using the estimated glomerular filtration rate (eGFR; a lower value indicates poorer kidney function). We performed ordinal logistic regression analyses to assess the association of the a* value with three eGFR categories: ≥90, 60-89 and <60 mL/min/1.73 m2.
RESULTS: The prevalence for each eGFR category was as follows: ≥90 (31.6%), 60-89 (63.8%) and <60 mL/min/1.73 m2 (4.6%). After adjusting for potential confounders, the a* value was found to be significantly associated with reduced kidney function. The multivariable-adjusted odds ratio (95% confidence interval) for reduced kidney function was 1.12 (1.02-1.22) per unit increase in the a* value.
CONCLUSIONS: Higher TLP activity was associated with reduced kidney function in Japanese workers.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:51 |
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| Enthalten in: |
Journal of clinical periodontology - 51(2024), 3 vom: 28. März, Seite 265-273 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Iwasaki, Masanori [VerfasserIn] |
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| Links: |
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| Themen: |
EC 3.4.21.4 |
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| Anmerkungen: |
Date Completed 19.02.2024 Date Revised 02.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/jcpe.13908 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM365088161 |
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| 100 | 1 | |a Iwasaki, Masanori |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The association between trypsin-like protease activity in the oral cavity and kidney function in Japanese workers |
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| 500 | |a Date Revised 02.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. | ||
| 520 | |a AIM: To evaluate the association between trypsin-like protease (TLP) activity in the oral cavity as an indicator of periodontal health status and kidney function in Japanese workers | ||
| 520 | |a MATERIALS AND METHODS: This cross-sectional study included 1117 Japanese workers (mean age = 43.8 years). Tongue-swab TLP activity was quantified as a* value (the redness intensity of the matrix disc of the TLP activity assessment kit; a larger value indicates more intense enzymatic activity in the samples and poorer periodontal health status). Kidney function was assessed using the estimated glomerular filtration rate (eGFR; a lower value indicates poorer kidney function). We performed ordinal logistic regression analyses to assess the association of the a* value with three eGFR categories: ≥90, 60-89 and <60 mL/min/1.73 m2 | ||
| 520 | |a RESULTS: The prevalence for each eGFR category was as follows: ≥90 (31.6%), 60-89 (63.8%) and <60 mL/min/1.73 m2 (4.6%). After adjusting for potential confounders, the a* value was found to be significantly associated with reduced kidney function. The multivariable-adjusted odds ratio (95% confidence interval) for reduced kidney function was 1.12 (1.02-1.22) per unit increase in the a* value | ||
| 520 | |a CONCLUSIONS: Higher TLP activity was associated with reduced kidney function in Japanese workers | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a epidemiology | |
| 650 | 4 | |a mass screening | |
| 650 | 4 | |a oral health | |
| 650 | 4 | |a periodontal diseases | |
| 650 | 7 | |a Trypsin |2 NLM | |
| 650 | 7 | |a EC 3.4.21.4 |2 NLM | |
| 700 | 1 | |a Inoue, Maki |e verfasserin |4 aut | |
| 700 | 1 | |a Usui, Michihiko |e verfasserin |4 aut | |
| 700 | 1 | |a Ariyoshi, Wataru |e verfasserin |4 aut | |
| 700 | 1 | |a Nakashima, Keisuke |e verfasserin |4 aut | |
| 700 | 1 | |a Nagai-Yoshioka, Yoshie |e verfasserin |4 aut | |
| 700 | 1 | |a Nishihara, Tatsuji |e verfasserin |4 aut | |
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