11 C]-PBR28 positron emission tomography signal as an imaging marker of joint inflammation in knee osteoarthritis
Copyright © 2023 International Association for the Study of Pain..
ABSTRACT: Although inflammation is known to play a role in knee osteoarthritis (KOA), inflammation-specific imaging is not routinely performed. In this article, we evaluate the role of joint inflammation, measured using [ 11 C]-PBR28, a radioligand for the inflammatory marker 18-kDa translocator protein (TSPO), in KOA. Twenty-one KOA patients and 11 healthy controls (HC) underwent positron emission tomography/magnetic resonance imaging (PET/MRI) knee imaging with the TSPO ligand [ 11 C]-PBR28. Standardized uptake values were extracted from regions-of-interest (ROIs) semiautomatically segmented from MRI data, and compared across groups (HC, KOA) and subgroups (unilateral/bilateral KOA symptoms), across knees (most vs least painful), and against clinical variables (eg, pain and Kellgren-Lawrence [KL] grades). Overall, KOA patients demonstrated elevated [ 11 C]-PBR28 binding across all knee ROIs, compared with HC (all P 's < 0.005). Specifically, PET signal was significantly elevated in both knees in patients with bilateral KOA symptoms (both P 's < 0.01), and in the symptomatic knee ( P < 0.05), but not the asymptomatic knee ( P = 0.95) of patients with unilateral KOA symptoms. Positron emission tomography signal was higher in the most vs least painful knee ( P < 0.001), and the difference in pain ratings across knees was proportional to the difference in PET signal ( r = 0.74, P < 0.001). Kellgren-Lawrence grades neither correlated with PET signal (left knee r = 0.32, P = 0.19; right knee r = 0.18, P = 0.45) nor pain ( r = 0.39, P = 0.07). The current results support further exploration of [ 11 C]-PBR28 PET signal as an imaging marker candidate for KOA and a link between joint inflammation and osteoarthritis-related pain severity.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2024 |
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Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:165 |
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Enthalten in: |
Pain - 165(2024), 5 vom: 01. Apr., Seite 1121-1130 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Sandström, Angelica [VerfasserIn] |
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Date Completed 16.04.2024 Date Revised 16.04.2024 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1097/j.pain.0000000000003114 |
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funding: |
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PPN (Katalog-ID): |
NLM365068039 |
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245 | 1 | 0 | |a 11 C]-PBR28 positron emission tomography signal as an imaging marker of joint inflammation in knee osteoarthritis |
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520 | |a ABSTRACT: Although inflammation is known to play a role in knee osteoarthritis (KOA), inflammation-specific imaging is not routinely performed. In this article, we evaluate the role of joint inflammation, measured using [ 11 C]-PBR28, a radioligand for the inflammatory marker 18-kDa translocator protein (TSPO), in KOA. Twenty-one KOA patients and 11 healthy controls (HC) underwent positron emission tomography/magnetic resonance imaging (PET/MRI) knee imaging with the TSPO ligand [ 11 C]-PBR28. Standardized uptake values were extracted from regions-of-interest (ROIs) semiautomatically segmented from MRI data, and compared across groups (HC, KOA) and subgroups (unilateral/bilateral KOA symptoms), across knees (most vs least painful), and against clinical variables (eg, pain and Kellgren-Lawrence [KL] grades). Overall, KOA patients demonstrated elevated [ 11 C]-PBR28 binding across all knee ROIs, compared with HC (all P 's < 0.005). Specifically, PET signal was significantly elevated in both knees in patients with bilateral KOA symptoms (both P 's < 0.01), and in the symptomatic knee ( P < 0.05), but not the asymptomatic knee ( P = 0.95) of patients with unilateral KOA symptoms. Positron emission tomography signal was higher in the most vs least painful knee ( P < 0.001), and the difference in pain ratings across knees was proportional to the difference in PET signal ( r = 0.74, P < 0.001). Kellgren-Lawrence grades neither correlated with PET signal (left knee r = 0.32, P = 0.19; right knee r = 0.18, P = 0.45) nor pain ( r = 0.39, P = 0.07). The current results support further exploration of [ 11 C]-PBR28 PET signal as an imaging marker candidate for KOA and a link between joint inflammation and osteoarthritis-related pain severity | ||
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700 | 1 | |a Kim, Minhae |e verfasserin |4 aut | |
700 | 1 | |a Alshelh, Zeynab |e verfasserin |4 aut | |
700 | 1 | |a Zhu, Yehui |e verfasserin |4 aut | |
700 | 1 | |a Li, Matthew D |e verfasserin |4 aut | |
700 | 1 | |a Chang, Connie Y |e verfasserin |4 aut | |
700 | 1 | |a Jarraya, Mohamed |e verfasserin |4 aut | |
700 | 1 | |a Akeju, Oluwaseun |e verfasserin |4 aut | |
700 | 1 | |a Schrepf, Andrew |e verfasserin |4 aut | |
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700 | 1 | |a Kwon, Young-Min |e verfasserin |4 aut | |
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700 | 1 | |a Chen, Antonia F |e verfasserin |4 aut | |
700 | 1 | |a Mercaldo, Nathaniel D |e verfasserin |4 aut | |
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