Examining the Effect of SARS-CoV-2 Pandemic-Induced Stress and Anxiety on Humoral Immunity in Health Care Workers
Copyright © 2023 American College of Occupational and Environmental Medicine..
OBJECTIVE: The effect of stress on vaccine-induced humoral immunity and therapeutic interventions to mitigate pandemic-related stress remain underexplored.
METHOD: Participants in a longitudinal cohort study ( n = 189) completed a validated measure, GAD-7, and 10-instrument stress measure to assess stress and anxiety after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. Serum was collected to obtain SARS-CoV-2 antibody titer levels.
RESULTS: Participants experienced increased stress due to the SARS-CoV-2 pandemic with a positive correlation between GAD-7 scores and peak antibody titers overall; however, there was a negative association with scores commensurate with severe anxiety. Health care workers and younger participants were more significantly affected by anxiety.
CONCLUSIONS: Mild anxiety levels may have immune-enhancing effects, whereas severe anxiety may cause antibody generation reduction. Mental health-focused interventions are imperative for younger adults and health care workers. Young adults may be more resilient to increased stress levels.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:66 |
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| Enthalten in: |
Journal of occupational and environmental medicine - 66(2024), 2 vom: 01. Feb., Seite e48-e53 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Stark, Valerie S [VerfasserIn] |
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| Anmerkungen: |
Date Completed 05.02.2024 Date Revised 18.02.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1097/JOM.0000000000003014 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM365045810 |
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| 100 | 1 | |a Stark, Valerie S |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Examining the Effect of SARS-CoV-2 Pandemic-Induced Stress and Anxiety on Humoral Immunity in Health Care Workers |
| 264 | 1 | |c 2024 | |
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| 500 | |a Date Completed 05.02.2024 | ||
| 500 | |a Date Revised 18.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 American College of Occupational and Environmental Medicine. | ||
| 520 | |a OBJECTIVE: The effect of stress on vaccine-induced humoral immunity and therapeutic interventions to mitigate pandemic-related stress remain underexplored | ||
| 520 | |a METHOD: Participants in a longitudinal cohort study ( n = 189) completed a validated measure, GAD-7, and 10-instrument stress measure to assess stress and anxiety after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. Serum was collected to obtain SARS-CoV-2 antibody titer levels | ||
| 520 | |a RESULTS: Participants experienced increased stress due to the SARS-CoV-2 pandemic with a positive correlation between GAD-7 scores and peak antibody titers overall; however, there was a negative association with scores commensurate with severe anxiety. Health care workers and younger participants were more significantly affected by anxiety | ||
| 520 | |a CONCLUSIONS: Mild anxiety levels may have immune-enhancing effects, whereas severe anxiety may cause antibody generation reduction. Mental health-focused interventions are imperative for younger adults and health care workers. Young adults may be more resilient to increased stress levels | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Williams, Erin C |e verfasserin |4 aut | |
| 700 | 1 | |a Echeverri Tribin, Felipe |e verfasserin |4 aut | |
| 700 | 1 | |a Coto, Jennifer |e verfasserin |4 aut | |
| 700 | 1 | |a Carrico, Adam |e verfasserin |4 aut | |
| 700 | 1 | |a Carreño, Juan Manuel |e verfasserin |4 aut | |
| 700 | 1 | |a Bielak, Dominika |e verfasserin |4 aut | |
| 700 | 1 | |a Desai, Parnavi |e verfasserin |4 aut | |
| 700 | 1 | |a Krammer, Florian |e verfasserin |4 aut | |
| 700 | 1 | |a Hoffer, Michael E |e verfasserin |4 aut | |
| 700 | 1 | |a Pallikkuth, Suresh |e verfasserin |4 aut | |
| 700 | 1 | |a Pahwa, Savita |e verfasserin |4 aut | |
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