Feasibility Study to Compare Oxytocin Function Between Body Mass Index Groups at Term Labor Induction
Copyright © 2023 AWHONN, the Association of Women’s Health, Obstetric and Neonatal Nurses. Published by Elsevier Inc. All rights reserved..
OBJECTIVE: To determine the feasibility of a protocol to examine the association between oxytocin system function and birth outcomes in women with and without obesity before induction of labor.
DESIGN: Prospective descriptive.
SETTING: Academic medical center in the U.S. Midwest.
PARTICIPANTS: Pregnant women scheduled for induction of labor at 40 weeks of gestation or greater (n = 15 normal weight; n = 15 obese).
METHODS: We collected blood samples and abstracted data by chart review. We used percentages to examine adherence to protocol. We used t tests and chi-square tests to describe differences in sample characteristics, oxytocin system function variables, and birth outcomes between the body mass index groups.
RESULTS: The recruitment rate was 85.7%, protocol adherence was 97.1%, and questionnaire completion was 80.0%. Mean plasma oxytocin concentration was higher in the obese group (M = 2774.4 pg/ml, SD = 797.4) than in the normal weight group (M = 2193.5 pg/ml, SD = 469.8). Oxytocin receptor DNA percentage methylation (CpG -934) was higher in the obese group than in the normal weight group.
CONCLUSION: Our protocol was feasible and can serve as a foundation for estimating sample sizes in forthcoming studies investigating the diversity in oxytocin system measurements and childbirth outcomes among pregnant women in different body mass index categories.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:53 |
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| Enthalten in: |
Journal of obstetric, gynecologic, and neonatal nursing : JOGNN - 53(2024), 2 vom: 12. März, Seite 140-150 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Maeder, Angela B [VerfasserIn] |
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| Links: |
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| Themen: |
50-56-6 |
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| Anmerkungen: |
Date Completed 11.03.2024 Date Revised 11.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jogn.2023.11.003 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
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| 100 | 1 | |a Maeder, Angela B |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Feasibility Study to Compare Oxytocin Function Between Body Mass Index Groups at Term Labor Induction |
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| 500 | |a Date Completed 11.03.2024 | ||
| 500 | |a Date Revised 11.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 AWHONN, the Association of Women’s Health, Obstetric and Neonatal Nurses. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a OBJECTIVE: To determine the feasibility of a protocol to examine the association between oxytocin system function and birth outcomes in women with and without obesity before induction of labor | ||
| 520 | |a DESIGN: Prospective descriptive | ||
| 520 | |a SETTING: Academic medical center in the U.S. Midwest | ||
| 520 | |a PARTICIPANTS: Pregnant women scheduled for induction of labor at 40 weeks of gestation or greater (n = 15 normal weight; n = 15 obese) | ||
| 520 | |a METHODS: We collected blood samples and abstracted data by chart review. We used percentages to examine adherence to protocol. We used t tests and chi-square tests to describe differences in sample characteristics, oxytocin system function variables, and birth outcomes between the body mass index groups | ||
| 520 | |a RESULTS: The recruitment rate was 85.7%, protocol adherence was 97.1%, and questionnaire completion was 80.0%. Mean plasma oxytocin concentration was higher in the obese group (M = 2774.4 pg/ml, SD = 797.4) than in the normal weight group (M = 2193.5 pg/ml, SD = 469.8). Oxytocin receptor DNA percentage methylation (CpG -934) was higher in the obese group than in the normal weight group | ||
| 520 | |a CONCLUSION: Our protocol was feasible and can serve as a foundation for estimating sample sizes in forthcoming studies investigating the diversity in oxytocin system measurements and childbirth outcomes among pregnant women in different body mass index categories | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a epigenetic | |
| 650 | 4 | |a induction of labor | |
| 650 | 4 | |a labor outcomes | |
| 650 | 4 | |a methylation | |
| 650 | 4 | |a obesity | |
| 650 | 4 | |a oxytocin | |
| 650 | 4 | |a oxytocin receptor | |
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| 650 | 7 | |a Oxytocics |2 NLM | |
| 700 | 1 | |a Bell, Aleeca F |e verfasserin |4 aut | |
| 700 | 1 | |a McFarlin, Barbara L |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Chang G |e verfasserin |4 aut | |
| 700 | 1 | |a Kominiarek, Michelle A |e verfasserin |4 aut | |
| 700 | 1 | |a Toledo, Paloma |e verfasserin |4 aut | |
| 700 | 1 | |a Carter, C Sue |e verfasserin |4 aut | |
| 700 | 1 | |a Nazarloo, Hans |e verfasserin |4 aut | |
| 700 | 1 | |a Vonderheid, Susan C |e verfasserin |4 aut | |
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