Metabolic Rewiring and Communication : An Integrative View of Kidney Proximal Tubule Function
The kidney proximal tubule is a key organ for human metabolism. The kidney responds to stress with altered metabolite transformation and perturbed metabolic pathways, an ultimate cause for kidney disease. Here, we review the proximal tubule's metabolic function through an integrative view of transport, metabolism, and function, and embed it in the context of metabolome-wide data-driven research. Function (filtration, transport, secretion, and reabsorption), metabolite transformation, and metabolite signaling determine kidney metabolic rewiring in disease. Energy metabolism and substrates for key metabolic pathways are orchestrated by metabolite sensors. Given the importance of renal function for the inner milieu, we also review metabolic communication routes with other organs. Exciting research opportunities exist to understand metabolic perturbation of kidney and proximal tubule function, for example, in hypertension-associated kidney disease. We argue that, based on the integrative view outlined here, kidney diseases without genetic cause should be approached scientifically as metabolic diseases.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:86 |
|---|---|
| Enthalten in: |
Annual review of physiology - 86(2024) vom: 12. Feb., Seite 405-427 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Chrysopoulou, Maria [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
AKI |
|---|
| Anmerkungen: |
Date Completed 14.02.2024 Date Revised 14.02.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1146/annurev-physiol-042222-024724 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM365032263 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM365032263 | ||
| 003 | DE-627 | ||
| 005 | 20240214232943.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1146/annurev-physiol-042222-024724 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1293.xml |
| 035 | |a (DE-627)NLM365032263 | ||
| 035 | |a (NLM)38012048 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Chrysopoulou, Maria |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Metabolic Rewiring and Communication |b An Integrative View of Kidney Proximal Tubule Function |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 14.02.2024 | ||
| 500 | |a Date Revised 14.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The kidney proximal tubule is a key organ for human metabolism. The kidney responds to stress with altered metabolite transformation and perturbed metabolic pathways, an ultimate cause for kidney disease. Here, we review the proximal tubule's metabolic function through an integrative view of transport, metabolism, and function, and embed it in the context of metabolome-wide data-driven research. Function (filtration, transport, secretion, and reabsorption), metabolite transformation, and metabolite signaling determine kidney metabolic rewiring in disease. Energy metabolism and substrates for key metabolic pathways are orchestrated by metabolite sensors. Given the importance of renal function for the inner milieu, we also review metabolic communication routes with other organs. Exciting research opportunities exist to understand metabolic perturbation of kidney and proximal tubule function, for example, in hypertension-associated kidney disease. We argue that, based on the integrative view outlined here, kidney diseases without genetic cause should be approached scientifically as metabolic diseases | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a AKI | |
| 650 | 4 | |a CKD | |
| 650 | 4 | |a SGLT2 | |
| 650 | 4 | |a amino acids | |
| 650 | 4 | |a diabetes | |
| 650 | 4 | |a fatty acid metabolism | |
| 650 | 4 | |a gluconeogenesis | |
| 650 | 4 | |a glycolysis | |
| 650 | 4 | |a ketone body metabolism | |
| 700 | 1 | |a Rinschen, Markus M |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Annual review of physiology |d 1946 |g 86(2024) vom: 12. Feb., Seite 405-427 |w (DE-627)NLM000046477 |x 1545-1585 |7 nnns |
| 773 | 1 | 8 | |g volume:86 |g year:2024 |g day:12 |g month:02 |g pages:405-427 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1146/annurev-physiol-042222-024724 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 86 |j 2024 |b 12 |c 02 |h 405-427 | ||