Prognostic utility of inflammatory indexes in critically ill newborns
Licencia CC 4.0 (BY-NC-ND) © 2023 Revista Médica del Instituto Mexicano del Seguro Social..
Background: Critically ill newborns (NB) are susceptible to serious complications due to their immature immune system.
Objective: To know the prognostic utility of inflammatory indexes in critically ill NBs.
Material and methods: Observational, analytical, longitudinal, prospective study. We included NBs hospitalized, critically ill and non-critically ill, who had a complete blood count at 12 hours of life (initial) and within 24 hours prior to discharge due to improvement or death (final). Systemic immune-inflammatory Index (SII), Neutrophil/Lymphocyte Ratio (NLR) and Platelets/Lymphocyte Ratio (PLR) were analyzed. There was follow-up from birth to discharge.
Results: 211 patients of 33 (32-34) weeks of gestation, weight 1.569 (1.480-1.720) kg. 106 critical NB and 105 non-critical NB, with 50 deaths in the former group, were analyzed. The final NLR ≥ 1.38 (sensitivity [S] 58%, specificity [Sp] 58%, AUC 0.60 [p 0.006]) identified critically ill NBs compared to non-critical ill NBs; final NLR ≥ 1.84 (S 71%, Sp 71%, AUC 0.79 [p < 0.0001]) identified critically ill NBs who died compared to all those who survived; final SII ≥ 255.411 x 103 (S 55%, Sp 56%, AUC 0.60 [p 0.047]) and final NLR ≥ 1.75 (S 76%, Sp 76%, AUC 0.84 [p < 0.0001]) identified critical NBs who died from those who survived.
Conclusion: The final NLR predicts which NBs may perish with respect to all who survive. The final NLR and SII predict among critically ill NBs who may die.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:61 |
|---|---|
| Enthalten in: |
Revista medica del Instituto Mexicano del Seguro Social - 61(2023), Suppl 2 vom: 18. Sept., Seite S171-S177 |
| Sprache: |
Spanisch |
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| Weiterer Titel: |
Utilidad pronóstica de los índices inflamatorios en recién nacidos críticamente enfermos |
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| Beteiligte Personen: |
Aguirre-Escojido, Alejandro [VerfasserIn] |
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| Themen: |
Critical Illness |
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| Anmerkungen: |
Date Completed 29.11.2023 Date Revised 08.01.2024 published: Electronic Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM365028312 |
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| 100 | 1 | |a Aguirre-Escojido, Alejandro |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Prognostic utility of inflammatory indexes in critically ill newborns |
| 246 | 3 | 3 | |a Utilidad pronóstica de los índices inflamatorios en recién nacidos críticamente enfermos |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Completed 29.11.2023 | ||
| 500 | |a Date Revised 08.01.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Licencia CC 4.0 (BY-NC-ND) © 2023 Revista Médica del Instituto Mexicano del Seguro Social. | ||
| 520 | |a Background: Critically ill newborns (NB) are susceptible to serious complications due to their immature immune system | ||
| 520 | |a Objective: To know the prognostic utility of inflammatory indexes in critically ill NBs | ||
| 520 | |a Material and methods: Observational, analytical, longitudinal, prospective study. We included NBs hospitalized, critically ill and non-critically ill, who had a complete blood count at 12 hours of life (initial) and within 24 hours prior to discharge due to improvement or death (final). Systemic immune-inflammatory Index (SII), Neutrophil/Lymphocyte Ratio (NLR) and Platelets/Lymphocyte Ratio (PLR) were analyzed. There was follow-up from birth to discharge | ||
| 520 | |a Results: 211 patients of 33 (32-34) weeks of gestation, weight 1.569 (1.480-1.720) kg. 106 critical NB and 105 non-critical NB, with 50 deaths in the former group, were analyzed. The final NLR ≥ 1.38 (sensitivity [S] 58%, specificity [Sp] 58%, AUC 0.60 [p 0.006]) identified critically ill NBs compared to non-critical ill NBs; final NLR ≥ 1.84 (S 71%, Sp 71%, AUC 0.79 [p < 0.0001]) identified critically ill NBs who died compared to all those who survived; final SII ≥ 255.411 x 103 (S 55%, Sp 56%, AUC 0.60 [p 0.047]) and final NLR ≥ 1.75 (S 76%, Sp 76%, AUC 0.84 [p < 0.0001]) identified critical NBs who died from those who survived | ||
| 520 | |a Conclusion: The final NLR predicts which NBs may perish with respect to all who survive. The final NLR and SII predict among critically ill NBs who may die | ||
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Critical Illness | |
| 650 | 4 | |a Enfermedad Crítica | |
| 650 | 4 | |a Infant, Newborn | |
| 650 | 4 | |a Inflamación | |
| 650 | 4 | |a Inflammation | |
| 650 | 4 | |a Linfocitos | |
| 650 | 4 | |a Lymphocytes | |
| 650 | 4 | |a Neutrophils | |
| 650 | 4 | |a Neutrófilos | |
| 650 | 4 | |a Recién Nacido | |
| 700 | 1 | |a Padilla-Soto, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Guevara-González, José de Jesús |e verfasserin |4 aut | |
| 700 | 1 | |a Reyes-Sosa, Arturo Maximiliano |e verfasserin |4 aut | |
| 700 | 1 | |a González, Alma Patricia |e verfasserin |4 aut | |
| 700 | 1 | |a Paque-Bautista, Carlos |e verfasserin |4 aut | |
| 700 | 1 | |a Ramos-Jiménez, Aurelia Del Carmen |e verfasserin |4 aut | |
| 700 | 1 | |a Rodríguez-Mejía, Evaldo Jesús |e verfasserin |4 aut | |
| 700 | 1 | |a Sosa-Bustamante, Gloria Patricia |e verfasserin |4 aut | |
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